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http://dx.doi.org/10.5806/AST.2006.19.4.275

Separation of racemic enantiomer carvedilol and its metabolites using capillary electrophoresis  

Jo, Cheon-Ho (Department of Chemistry, Kyonggi University)
Koo, So-Hyun (Department of Chemistry, Kyonggi University)
Myung, Seung-Woon (Department of Chemistry, Kyonggi University)
Publication Information
Analytical Science and Technology / v.19, no.4, 2006 , pp. 275-279 More about this Journal
Abstract
A capillary electrophoresis method for the separation of carvedilol and its metabolites enantiomers using cyclodextrins as the chiral selectors was developed. The effect of several types of cyclodextrins, concentration and capillary temperature for enantiomer resolution were investigated. Best results were obtained by 15 mM carboxymethyl-${\beta}$-cyclodextrin in the run buffer. Also the effect of capillary temperature on efficiency was assessed. The optimized method was applied for separation of chiral carvedilol and its three metabolites.
Keywords
carvedilol; metabolite; enantiomer; capillary electrophoresis; separation;
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