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http://dx.doi.org/10.5806/AST.2006.19.3.218

Synthesis of molecularly imprinted polymer (MIP) by radiation-induced polymerization and separation of ferulic acid from rice oil using MIP-packed column  

Yoon, Seok-Kee (Department of Chemistry, Hannam University)
Lee, Jae-Chan (Department of Chemistry, Hannam University)
Lee, Seung-Ho (Department of Chemistry, Hannam University)
Choi, Seong-Ho (Department of Chemistry, Hannam University)
Kim, Hwa-Jung (BioDreams, Bio-Venture Center)
Park, Hae-Jun (BioDreams, Bio-Venture Center)
Kang, Hee-Dong (Department of Physics, Kyungpook National University)
Publication Information
Analytical Science and Technology / v.19, no.3, 2006 , pp. 218-225 More about this Journal
Abstract
A molecularly imprinted polymer (MIP) was synthesized by radiation-induced polymerization (RIP), where the ferulic acid was used as a template molecule, 4-vinylpyridine as a monomer and ethylene glycoldimethacrylate (EGDMA) as a cross-linking monomer. The MIP was packed in a glass column using a slurry method for use in medium pressure liquid chromatography (MPLC). The MPLC column was tested for separation and purification of ferulic acid from the rice oil. When repeated three times, the MPLC separation/purification yielded the ferulic acid with the purity higher than ~99%. The chemiluminescence of the luminal (5-amino-2,3-dihydro-1,4-phtalazinedione) measured on a potato disc slide (5.0 mm thick) was enhanced in the presence of ferulic acid, while, without the ferulic acid, the chemiluminescence of luminol on the potato slice disc was not observed, which suggests the ferulic acid obtained from the rice oil can be useful for immunoassay.
Keywords
Molecularly imprinted polymer (MIP); Radiation-induced polymerization (RIP); Ferulic acid; Rice oil; Chemiluminescence; Potato;
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