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The chemical composition and biological activities of volatile flavor components of Elsholtzia splendens  

Jeong, Jae Hoon (Department of Industrial Plant Science, Colleage of Agriculture, Life & Environment Science, Chungbuk National University)
Lim, Heung Bin (Department of Industrial Plant Science, Colleage of Agriculture, Life & Environment Science, Chungbuk National University)
Publication Information
Analytical Science and Technology / v.18, no.6, 2005 , pp. 500-510 More about this Journal
Abstract
This study was conducted to investigate the chemical composition of essential oil, absolute and oleoresin isolated from Elsholtzia splendens and their biological activities. Yields of essential oil, absolute and oleoresin extracted from Elsholtzia splendens were 0.28%, 12.45% and 9.95%, respectively. The major component was 2-cyclohexen-1-one in essential oil, methyl linolenate in absolute and 9,12,15-octadecatrienoic acid in oleoresin. Essential oil and oleoresin showed the inhibitory activities in enzyme-dependent, enzyme-independent and autooxidative lipid peroxidation system. $EC_{50}$ values in nuetral red uptake (NRU) assays for the exposure times of 24 h were $46.4{\mu}g/ml$, $681.7{\mu}g/ml$ and $17.6{\mu}g/ml$ in essential oil, absolute and oleoresin, and oleoresins showed the cytotoxic effect at the only high dose. Any mutagenic and antibiotic activity did not show in absolute and oleoresin, but, there were mutagenic and antibiotic activities only when treated with essential oil $500{\mu}g/ml$ above in Ames test. Essential oil and oleoresin might be somewhat effective in prolongating the ciliostasis of rat trachea.
Keywords
Elsholtzia splendens; volatile flavor components; NRU assay; Ames test; ciliostasis; lipid peroxidation;
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