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Comparisons of sample preparation (acid digestion and microwave digestion) and measurement (inductively coupled plasma mass spectrometry and graphite furnace atomic absorption spectrometry) in the determination of bone lead

Yoon, Chungsik (Department of Occupational Health, Catholic University of Daegu)
Choi, Inja (Wonjin Institute for Occupational & Environmental Health)
Park, Sungkyun (Department of Environmental Health, Harvard School of Public Health)
Kim, Rokho (Department of Environmental Health, Harvard School of Public Health)

Publication Information

Analytical Science and Technology / v.16, no.2, 2003 , pp. 152-158 More about this Journal

Abstract

This study was conducted to evaluate two sample digestion procedures and instrumental determination parameters for analysis of lead in bone. Amputated human legs were treated by acid digestion or microwave dissolution prior to spectrometric analysis. Inductively coupled plasma mass spectrometry (ICP-MS) and graphite furnace atomic absorption spectrometry (GF-AAS) were used for determining bone lead levels. Recovery efficiencies using standard reference material from acid digestion measured by ICP-MS were in good agreement with those of the certified value, but in cases of acid digestion by GF-AAS and microwave digestion by both two methods, recovery underestimated and overestimated, respectively. For the bone samples, the lead concentrations obtained by ICP-MS after acid digestionwere in good agreement with those by GF-AAS (correlation coefficient = 0.983), but GF-AAS gave systematically higher values than ICP-MS. While a good agreement between two analytical methods after microwave digestion was also obtained (correlation coefficient = 0.950), bone lead concentrations from microwave were relatively higher than those from acid digestion. In conclusion, the use of the simple nitric acid digestion procedure at an ambient temperature coupled to ICP-MS seems to be efficient for the determination of lead in bone in consideration for both the convenience and validity.

Keywords

bone lead; acid digestion; microwave oven; SRM; ICP-MS; GF-AAS;

Citations & Related Records

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