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Determination of Diazepam in Intact Diazepam Tablets Using Near Infrared Spectroscopy  

Choi, Hyun Cheol (Drug Evaluation in Korea Food & Drug Administration)
Kang, Shin Jung (Drug Evaluation in Korea Food & Drug Administration)
Youn, Mi Ok (Drug Evaluation in Korea Food & Drug Administration)
Lee, Su Jung (Drug Evaluation in Korea Food & Drug Administration)
Kim, Ho Jung (Drug Evaluation in Korea Food & Drug Administration)
Kim, Ji Yeon (Drug Evaluation in Korea Food & Drug Administration)
Cha, Ki Won (Department of Chemistry, Inha University)
Publication Information
Analytical Science and Technology / v.15, no.3, 2002 , pp. 243-247 More about this Journal
Abstract
A rapid and simple determination of diazepam in intact diazepam tablets has been investigated using the near infrared spectroscopy(NIRS) combined with partial least squares regession. The separate calibration curves of 2 mg and 5 mg diazepam tablets were studied, as well as the linearity, concentration range and reproducibility of those calibration curves were evaluated. The correlation coefficients of calibration curves of 2 mg and 5 mg diazepam tablets are 0.9416 and 0.9159, respectively and the standard errors of calibration curves(SEC) are 0.018% and 0.032%, respectively.
Keywords
NIR spetroscopy; partial least squares regression; diazepam; pharmaceutical analysis;
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  • Reference
1 M. Blanco, J. Coello, H. Iturriaga and S. Maspoch, Analyst, 123, 135 (1998).
2 A. C. Moffst, 'Meeting the International Conference on Harmonisation Guidelines on Validation of Analytical Procedures', 20th, June (2000).
3 H. Chang, H. J. Kim, D.Y. Meang, and J. H. Cho, Yachak Hoeji, 42(6) 545(1998).
4 C. I. Gerhausser and K. A. Kovar, Applid Spectroscopy , 51, 10 (1997).
5 P. Corti, E. Dreassi, G. Corbini, L. Montecchi, J. Paggi, Analysis, 18(2)b117 (1990).
6 P. Corti, E. Dreassi, G. Corbini and R. Vivia, Analysis, 19(7), 198 (1999).
7 B. R. Buchanan, M. A. Baxter, and P. A. Robinson, Parmaceutical Research, 13, 4 (1996).
8 C. I. Gerhausser and Karl- Artur Kovar, Applied Spectroscopy, 51(10)(1997).
9 W. H. T. Byron and J. Sellors, American Laboratory, 29, 20 (1997).
10 K.W. Cha, K. R. Ze, M. O. Youn, H. C. Choi and H. J. Kim, Analytical Science & Technology, 15(2),392 (2002).
11 European Pharmacopoeia, Near-infrared Spectroscopy, 43(1997).
12 D.A. Bums, E.W. Ciurczak, Handbook of Near-infra Analysis, 1-4 (1997).
13 H.J. Kim, Analyst, 124,203 (1999).