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Determination of Phenobarbital in Intact Phenobabital Tablets using NIRS  

Cha, Ki-Won (Department of Chemistry, Inha University)
Ze, Keum Ryon (Drug Evaluation in Korea Food & Drug Administration)
Youn, Mi Ok (Drug Evaluation in Korea Food & Drug Administration)
Lee, Su Jung (Drug Evaluation in Korea Food & Drug Administration)
Choi, Hyun Cheol (Drug Evaluation in Korea Food & Drug Administration)
Kim, Ho Jung (Drug Evaluation in Korea Food & Drug Administration)
Kim, Hyo Jin (Department of Pharmacy, Dongduk Women's University)
Publication Information
Analytical Science and Technology / v.15, no.2, 2002 , pp. 102-107 More about this Journal
Abstract
This paper describes a rapid determination of phenobarbital in intact phenobarbital tablets using partial least squares regression(PLSR) method of transmittance spectrum of near infrared (NIR) compared with the analytical data of liquid chromatograpy. The linearity, concentration range and precision of this analytical method are studied. The correlation coefficient of the calibration curve is 0.9983 and the standard error of calibration(SEC) is 0.14 %. Intra-day precision and Inter-day precision obtained in this method are CV = 0.45, CV =0.56, respectively.
Keywords
near infrared spectroscopy; partial least square regression; phenobarbital;
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