Seismologists now suggest that the earth has entered an active seismic period; many earthquake-related events are occurring globally. Consequently, numerous casualties, as well as economic losses due to earthquakes, have been reported in recent years. Primarily, significant and colossal damage occurs in reinforced concrete (RC) buildings with masonry infill wall systems, and the construction of these types of structures have increased worldwide. According to a report from the Ministry of Education in the Republic of Korea, many buildings were built with RC frames with masonry infill walls in the Republic of Korea during the 1980s. For years, most structures of this type have been school buildings, and since the Pohang earthquake in 2017, the government of the Republic of Korea has paid close attention to this social event and focused on damage from earthquakes. From a long-term research perspective, damage from structural collapse due to the short column effect has been a major concern, specifically because the RC frame with a masonry infill wall system is the typical form of structure for school buildings. Therefore, the short column effect has recently been a major topic for research. This study compares one RC frame with four different types of RC frames with masonry infill wall systems. Structural damage due to the short column effect is clearly analyzed, as the result of this research is giving in a higher infill wall system produces a greater shear force on the connecting point between the infill wall system and the column. The study is expected to be a useful reference for research on the short column effect in RC frames with masonry infill wall systems.