Airlines service is very important so as to overcome the rapid environmental changes of the air transportation market at home and abroad. Author investigates the impact of Determinants on the performance of airlines in all the world. Three variables of performance measurement were used : revenue, net profit, and passengers. Data analyses were based on service ranking, financial and passenger information of the world's top 50 Airlines collected from Business Traveller, World Air Transport Statistics and Airline Business. The findings of this study could be summarized as follows : Service ranking was not related to the airlines performances such as revenue, net profit, passengers and so fourth. But airlines size(employees, fleet size) was related to the airlines performances such as passengers and revenue passenger.