Purpose: This study aimed to provide a systematic review of the evidence from controlled trials regarding nursing intervention studies on patients undergoing percutaneous coronary intervention, a discussion of the methodological problems that limit current research, and suggestions regarding future directions for research. Methods: Using a predefined protocol, 27 electronic databases were searched, studies selected, relevant data extracted, and the methodological quality of the studies assessed. Results: Twenty-seven studies were found reporting complex, generally heterogeneous interventions. The studies reported positive results, including self-efficacy, knowledge, and self-care. There were 6 randomized controlled trials, 19 quasi-experimental studies, and 2 only research group studies. In addition to support components, the interventions included elements of teaching, counseling, and education. Nursing interventions are still in the developmental and testing phase. Conclusion: The review demonstrated that a great deal is known about nursing intervention, the impact on a range of outcomes, and methodology. Although some useful evidence was reported for all interventions, further research needs to be carried out.