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대사적 관점에서 간주풍(肝主風)에 관한 소고(小考)

A New Consideration of the 'Liver governing the Wind' from a Metabolic Viewpoint

  • 박미소 (대전대학교 한의학과 심계내과학교실) ;
  • 조정효 (대전대학교 한의학과 간계내과학교실)
  • Miso S. Park (Department of Cardiology and Neurology of Korean Medicine, College of Korean Medicine, Daejeon University) ;
  • Junghyo Cho (Department of Hepatology and Hematology of Korean Medicine, College of Korean Medicine, Daejeon University)
  • 투고 : 2024.09.26
  • 심사 : 2024.10.25
  • 발행 : 2024.10.25

초록

The liver is a major organ in human metabolism and is responsible for systemic circulation and metabolism. The traditional concepts of wind related to the nervous and motor system have limitations in explaining the role of the liver in human metabolism. To overcome these limitations, it is necessary to focus on the physiological activity and pivotal role of bioactive gases in the metabolism of gas flow. Additionally, the action of bioactive gases occurs in the presence of chromoprotein, such as heme protein, which acts as a photoreceptor between the eyes and the liver, ultimately involved in the circadian cycle and metabolism. This series of processes demonstrates that the unique theories of Korean medicine-where the liver governs the wind and the eyes-are accurately aligned from a metabolic perspective, suggesting that Korean medicine physiology can be integrated and appreciated from a modern medical standpoint.

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참고문헌

  1. Kim MH, Kim BS. Study on the concept and its structure of visceral system in current traditional Korean medicine. J Physiol Pathol Korean Med. 2017;31(6):305-12. 
  2. Zhenguao W, Peiping X, Ping C. History and development of traditional Chinese medicine (advanced traditional Chinese medicine series). Amsterdam: IOS Press; 2000. 
  3. Professors of Hepatology of Korean Medicine, Nationwide Colleges of Korean Medicine. Hepatology in Korean Medicine, 7th Edition. Seoul: Woori Medical Books; 2024. p. 9-10, 409-411. 
  4. Noh EJ. Herbal Clinical Clues. Seoul: Bareun Herbal Medicine Publisher; 2018. p. 16, 592. 
  5. Dashtdar M, Dashtdar MR, Dashtdar B, Kardi K, Shirazi MK. The Concept of Wind in Traditional Chinese Medicine. J Pharmacopuncture. 2016;19(4):293-302. 
  6. Dashtdar M. Textbook of acupuncture. Riga: VDM Verlag Dr. Muller; 2010. 
  7. Huang PX, Liu MC. Stroke and Parkinson's disease: the clinical practice of Chinese medicine. Washington D.C.: People's Medical Publishing House; 2007. 
  8. Walters R. The alternative cancer therapy book. New York: Avery Publishing Group; 1992. 
  9. Wikipedia. "Wind." Last modified September 4, 2024. Available from: https://en.wikipedia.org/wiki/Wind. 
  10. Kim, HP. Oxygen and Its Competitors. Seoul: JJisikeul Mandeuneun Jisik, 2013. p. 12-14, 57, 72, 83, 95, 173, 197. 
  11. Miller SL. A production of amino acids under possible primitive earth conditions. Science. 1953;117(3046):528-9. 
  12. Qi W, Man L, Suguro S, Zhao Y, Quan H, Huang C, et al. Endocrine effects of three common gas signaling molecules in humans: A literature review. Front Endocrinol. 2022;13:1074638. 
  13. Anbalagan S. Oxygen is an essential gasotransmitter directly sensed via protein gasoreceptors. Anim Models Exp Med. 2024;7(2):189-93. 
  14. Wang R. Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. Physiol Rev. 2012;92(2):791-896. 
  15. Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med. 1993;329(27):2002-12. 
  16. Forstermann U, Sessa WC. Nitric oxide synthases: regulation and function. Eur Heart J. 2012;33(7):829-37. 
  17. Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA. 1987;84(24):9265-9. 
  18. Pardee KI, Xu X, Reinking J, Schuetz A, Dong A, Liu S, et al. The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBβ. PLoS Biol. 2009;7(2):e1000043. 
  19. Freeman SL, Kwon H, Portolano N, Parkin G, Venkatraman Girija U, Basran J, et al. Heme binding to human CLOCK affects interactions with the E-box. Proc Natl Acad Sci USA. 2019;116(40):19911-6. 
  20. Kozlov A, Koch R, Nagoshi E. Nitric oxide mediates neuro-glial interaction that shapes Drosophila circadian behavior. PLoS Genet. 2020;16(6):e1008312. 
  21. Kunieda T, Minamino T, Miura K, Katsuno T, Tateno K, Miyauchi H, et al. Reduced nitric oxide causes age-associated impairment of circadian rhythmicity. Circ Res. 2008;102(5):607-14. 
  22. Ryter SW, Alam J, Choi AM. Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol Rev. 2006;86(2):583-650. 
  23. Motterlini R, Otterbein LE. The therapeutic potential of carbon monoxide. Nat Rev Drug Discov. 2010;9(9):728-43. 
  24. Minegishi S, Sagami I, Negi S, Kano K, Kitagishi H. Circadian clock disruption by selective removal of endogenous carbon monoxide. Sci Rep. 2018;8(1):11996. 
  25. Jin S, Tan B, Teng X, Meng R, Jiao X, Tian D, et al. Diurnal fluctuations in plasma hydrogen sulfide of the mice. Front Pharmacol. 2017;8:682. 
  26. Shang Z, Lu C, Chen S, Hua L, Qian R. Effect of H 2 S on the circadian rhythm of mouse hepatocytes. Lipids Health Dis. 2012;11:1-7. 
  27. Hu J, Xue Y, Tang K, Fan J, Du J, Li W, et al. The protective effects of hydrogen sulfide on the myocardial ischemia via regulating Bmal1. Biomed Pharmacother. 2019;120:109540. 
  28. Zhang H, Dai J, Tian D, Xiao L, Xue H, Guo Q, et al. Hydrogen sulfide restored the diurnal variation in cardiac function of aging mice. Oxid Med Cell Longev. 2021;2021(1):8841575. 
  29. Wu DD, Wang DY, Li HM, Guo JC, Duan SF, Ji XY. Hydrogen sulfide as a novel regulatory factor in liver health and disease. Oxid Med Cell Longev. 2019;2019(1):3831713. 
  30. Kajimura M, Nakanishi T, Takenouchi T, Morikawa T, Hishiki T, Yukutake Y, et al. Gas biology: tiny molecules controlling metabolic systems. Respir Physiol Neurobiol. 2012;184(2):139-48. 
  31. Griffett K, Hayes ME, Boeckman MP, Burris TP. The role of REV-ERB in NASH. Acta Pharmacol Sin. 2022;43(5):1133-40. 
  32. Sarkar A, Carter EL, Harland JB, Speelman AL, Lehnert N, Ragsdale SW. Ferric heme as a CO/NO sensor in the nuclear receptor Rev-Erbss by coupling gas binding to electron transfer. Proc Natl Acad Sci USA. 2021;118(3):e2016717118. 
  33. Wikipedia. "Chromoprotein." Last modified December 3, 2023. Available from: https://en.wikipedia.org/wiki/Chromoprotein. 
  34. Blackshaw S, Snyder SH. Encephalopsin: a novel mammalian extraretinal opsin discretely localized in the brain. J Neurosci. 1999;19(10):3681-90. 
  35. Halford S, Freedman MS, Bellingham J, Inglis SL, Poopalasundaram S, Soni BG, et al. Characterization of a novel human opsin gene with wide tissue expression and identification of embedded and flanking genes on chromosome 1q43. Genomics. 2001;72(2):203-8. 
  36. Tsin A, Betts-Obregon B, Grigsby J. Visual cycle proteins: Structure, function, and roles in human retinal disease. J Biol Chem. 2018;293(34):13016-21. 
  37. Tosini G, Ferguson I, Tsubota K. Effects of blue light on the circadian system and eye physiology. Mol Vis. 2016;22:61-72. 
  38. Marcheva B, Ramsey KM, Peek CB, Affinati A, Maury E, Bass J 2013. Circadian clocks and metabolism. Handb Exp Pharmacol 217:127-55 
  39. Gopalakrishnan S, Yadav SR, Kannan NN. A role for the circadian photoreceptor CRYPTOCHROME in regulating triglyceride metabolism in Drosophila. G3: Genes Genomes Genet. 2024:jkae220. 
  40. Michael AK, Fribourgh JL, Van Gelder RN, Partch CL. Animal cryptochromes: divergent roles in light perception, circadian timekeeping and beyond. Photochem Photobiol. 2017;93(1):128-40. 
  41. Sherrard RM, Morellini N, Jourdan N, El-Esawi M, Arthaut LD, Niessner C, Rouyer F, Klarsfeld A, Doulazmi M, Witczak J, d'Harlingue A. Low-intensity electromagnetic fields induce human cryptochrome to modulate intracellular reactive oxygen species. PLoS Biol. 2018;16(10):e2006229. 
  42. Chae KS, Oh IT, Lee SH, Kim SC. Blue light-dependent human magnetoreception in geomagnetic food orientation. PLoS One. 2019;14(2):e0211826. 
  43. Rui L. Energy metabolism in the liver. Compr Physiol. 2014;4(1):177-97.