한국식품위생안전성학회지 (Journal of Food Hygiene and Safety)

  • 제39권5호
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  • Pages.378-389
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  • 2024
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  • 1229-1153(pISSN)
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  • 2465-9223(eISSN)
한국식품위생안전성학회 (The Korean Society of Food Hygiene and Safety)
권호 표지
DOI QR코드

DOI QR Code

해양생물독소의 신속 검출을 위한 친화성 바이오리셉터 기반 바이오센서 개발 동향

Trends in Development of Affinity Bioreceptor-based Biosensor for Rapid Detection of Marine Biotoxins

  • 조채환 (중앙대학교 생명공학대학 식품공학과) ;
  • 박태정 (중앙대학교 화학과) ;
  • 박종필 (중앙대학교 생명공학대학 식품공학과)
  • Chae Hwan Cho (Department of Food Science and Technology, College of Biotechnology and Natural Resources, GreenTech-Based Food Safety Research Group (BK21 Four), Chung-Ang University) ;
  • Tae Jung Park (Department of Chemistry, Institute of Interdisciplinary Convergence Research, Research Institute of Chem-Bio Diagnostic Technology, Chung-Ang University) ;
  • Jong Pil Park (Department of Food Science and Technology, College of Biotechnology and Natural Resources, GreenTech-Based Food Safety Research Group (BK21 Four), Chung-Ang University)
  • 투고 : 2024.10.02
  • 심사 : 2024.10.15
  • 발행 : 2024.10.30
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초록

기후 변화로 인한 해양 온도 상승으로 해양생물독소의 발생 빈도가 점점 증가하고 있으며, 이는 식품 안전과 공중 보건에 중대한 위협을 가하고 있다. 해양생물독소를 검출하기 위한 기존의 방법인 마우스 생체검사(MBA), 고성능 액체 크로마토그래피(HPLC), 액체 크로마토그래피-질량 분석법(LC-MS) 등은 절차가 오래 걸리고 비용이 많이 든다는 한계가 있다. 이러한 문제를 해결하기 위한 대안으로 바이오센서 기술이 유망한 해결책으로 부상하고 있다. 이러한 바이오센서는 세포, 항체, 압타머, 펩타이드와 같은 바이오리셉터를 이용해 해양생물독소를 신속하고 정확하게 검출한다. 본 리뷰에서는 다양한 종류의 바이오리셉터를 논의하고, 해양생물독소 검출을 위한 바이오센서 기술의 최근 발전을 탐구한다. 또한, 이러한 바이오리셉터의 장점을 강조하며, 해양생물독소 검출을 위한 바이오센서 성능 향상을 위한 미래 연구 방향을 고려한다.

Marine biotoxins are becoming increasingly prevalent due to rising ocean temperatures driven by global warming, posing serious threats to food safety and public health. Traditional detection methods for marine biotoxins, such as mouse bioassays, high-performance liquid chromatography, and liquid chromatography-mass spectrometry, are limited by time-consuming procedures and high costs. Biosensor technology has emerged as a promising alternative. These biosensors employ bioreceptors (such as cells, antibodies, aptamers, and peptides) to detect marine biotoxins rapidly and accurately. In this review, we discuss the various types of bioreceptors and explore recent developments in biosensor technologies for marine biotoxin detection. Furthermore, we highlight the advantages of these bioreceptors and consider future directions for improving biosensor performance in detecting marine biotoxins.

키워드

과제정보

본 연구는 2024년도 식품의약품안전처의 연구개발비(20163MFDS641)로 수행되었으며, 이에 감사드립니다.

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