Coil Phenomenon that Occurs in Hair Loss Patients after Autologous Micro Transplantation and the Effect of Targeted Exosomes on Hair Growth

Recently, as a method of hair loss treatment, a non-surgical method of applying the technology of isolating a patient's specific autologous progenitor cells after biopsy and using it by injecting isolated uncultured targeted exosomes has been suggested. The effect of progenitor cell micrograft is that hair loss is treated by maintaining the micro environment by side population phenomena, niche concept, and extracellular matrix (ECM). In this experiment, a female patient in her 50s was observed for about five months from the micrograft in June until October 2023, and the experimental equipment used in this experiment was the Bio-Q developed by a local specialized technology development project. For the experiment, a biopsy of 2,5 ∅ 3 punches was performed on the back of the patient's head where there was no hair loss, and about 5cc (0.1cc each) of suspension (targeted exosomes) was immediately injected on the same day into 50 sites on her scalp where hair loss occurred, and the hair growth status was investigated afterward. Hair growth occurred at the micrograft sites, but many hairs with weak hair growth that had not yet penetrated the epidermal layer were observed growing in coils at the lower part of the epidermal layer, and the length of the coils was also found to increase at the bottom of the scalp. The number of hairs with hair growth capability increased rapidly after discovering the cause of the coil phenomenon.