Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
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Trace element and cytokine imbalances in calves with dermatophytosis

  • Han Gyu Lee (Division of Animal Diseases and Health, National Institute of Animal Science, Rural Development Administration) ;
  • Ara Cho (Division of Animal Diseases and Health, National Institute of Animal Science, Rural Development Administration) ;
  • Ui-Hyung Kim (Hanwoo Research Institute, National Institute of Animal Science, Rural Development Administration) ;
  • Sihyun An (Agricultural Microbiology Division, National Institute of Agricultural Sciences, Rural Development Administration) ;
  • Yoon Jung Do (Division of Animal Diseases and Health, National Institute of Animal Science, Rural Development Administration) ;
  • Changyong Choe (Division of Animal Diseases and Health, National Institute of Animal Science, Rural Development Administration) ;
  • Are Sun You (Division of Animal Diseases and Health, National Institute of Animal Science, Rural Development Administration) ;
  • Young-Hun Jung (Division of Animal Diseases and Health, National Institute of Animal Science, Rural Development Administration) ;
  • Seogjin Kang (Division of Animal Diseases and Health, National Institute of Animal Science, Rural Development Administration) ;
  • Eun-Yeong Bok (Division of Animal Diseases and Health, National Institute of Animal Science, Rural Development Administration)
  • Received : 2024.08.28
  • Accepted : 2024.09.13
  • Published : 2024.09.30
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Abstract

Bovine dermatophytosis is a highly contagious disease that adversely affects animal growth and reduces meat and milk production. Nutritional deficiencies and immune status are suspected risk factors, but their roles remain unclear. This study investigates the association between trace minerals, vitamins, serum biochemical parameters, and immune-related cytokines with bovine dermatophytosis. Forty calves aged 6~7 months were selected and raised together on the same farm. They were divided into two groups: the control group (n=20) and the infected group (n=20). Serum was collected and analyzed for serum trace minerals, vitamins, biochemical parameters, and cytokine levels. Trichophyton verrucousm was isolated from infected calves. The infected calves had significantly lower zinc (P<0.001) and vitamin E (P=0.02) levels and significantly higher interleukin (IL)-6 (P=0.014) and IL-17A (P=0.018) levels. Regarding serum biochemical parameters, glucose (P=0.008) and total bilirubin (P=0.003) levels were significantly higher in the infected calves than in healthy ones. Hyperglobulinemia and high alkaline phosphatase levels were observed in the infected calves, without statistical significance. Our findings suggest the necessity of considering nutritional elements such as zinc and vitamin E for the prevention and treatment of bovine dermatophytosis. Additionally, the observed changes in immune and serum biochemistry factors post-infection may provide a foundation for future research on the host's biological responses to infection.

Keywords

Acknowledgement

This research was supported by the project 'The Improvement of Animal Disease Control in National Institute of Animal Science' (Project No. PJ01567602), funded by the Rural Development Administration of South Korea.

References

  1. Al-Ani F, Younes F, Al-Rawashdeh O. 2002. Ringworm infection of cattle and horses in Jordan. Acta Veterinaria Brno 71: 55-60.
  2. Al-Qudah KM, Gharaibeh AA, Al-Shyyab MM. 2010. Trace minerals status and antioxidant enzymes activities in calves with dermatophytosis. Biol Trace Elem Res 136: 40-47.
  3. Almeida SR. Immunology of dermatophytosis. 2008. Mycopathologia. 166:277-83.
  4. Antachopoulos C, Roilides E. 2005. Cytokines and fungal infections. Br J Haematol 129: 583-596.
  5. Atakisi E, Karapehlivan M, Atakisi O, Kontas T, Marasli S. 2006. Adenosine deaminase and biochemical liver function tests in the dermatophytic cattle. Bull Vet Inst Pulawy 50: 481-430.
  6. Balikci E. 2016. Antidermatophyte and antioxidant activities of Nigella sativa alone and in combination with enilconazole in treatment of dermatophytosis in cattle. Veterinarni medicina 61: 539-545.
  7. Betul AY. 2020. Evaluation of biochemical parameters and oxidative stress in native and crossbred cattle naturally infected with Dermatophytosis. GSC Biol Pharm Sci 13: 99-104.
  8. Blackmon DM, Miller WJ, Morton JD. 1967. Zinc deficiency in ruminants. Occurrence, effects, diagnosis and treatments. Vet Med Small Anim Clin 62: 265-270.
  9. Burstein VL, Beccacece I, Guasconi L, Mena CJ, Cervi L, Chiapello LS. 2020. Skin immunity to dermatophytes: From experimental infection models to human disease. Front Immunol 11: 605644.
  10. Chase CC, Hurley DJ, Reber AJ. 2008. Neonatal immune development in the calf and its impact on vaccine response. Vet Clin North Am Food Anim Pract 24: 87-104.
  11. Dalis JS, Kazeem HM, Kwaga JKP, Kwanashie CN. 2019. Prevalence and distribution of dermatophytosis lesions on cattle in Plateau State, Nigeria. Vet World 12: 1484-1490.
  12. Davies SJ, Esposito G, Villot C, Chevaux E, Raffrenato E. 2022. An evaluation of nutritional and therapeutic factors affecting pre-weaned calf health and welfare, and direct-fed microbials as a potential alternative for promoting performance-a review. Dairy 3: 648-667.
  13. Glowacka E, Lewkowicz P, Rotsztejn H, Zalewska A. 2010. IL-8, IL-12 and IL-10 cytokines generation by neutrophils, fibroblasts and neutrophils- fibroblasts interaction in psoriasis. Adv Med Sci 55: 254-260.
  14. Hameed K, Riaz Ch F, Nawaz MA, Naqvi SMS, Graser Y, Kupsch C. 2017. Trichophyton verrucosum infection in livestock in the Chitral district of Pakistan. J Infect Dev Ctries 11: 326-333.
  15. Jankovic D, Kugler DG, Sher A. 2010. IL-10 production by CD4+ effector T cells: a mechanism for self-regulation. Mucosal Immunol 3(3): 239-246.
  16. Kabu M, Koca HB. 2018. The levels of some biochemical parameters in Anatolian buffaloes with trichophytosis. Kocatepe Vet J 11(2): 156-159.
  17. Kesler KW, Abuelo A. 2024. Zinc about it - zinc and calf immunity. Front Immunol 15: 1387950.
  18. Kojouri GA, Ebrahimi A, Zaheri M. 2009. Zinc and selenium status in cows with dermatophytosis. Comp Clin Path 18: 283-286.
  19. Krametter-Froetscher R, Hauser S, Baumgartner W. 2005. Zinc-responsive dermatosis in goats suggestive of hereditary malabsorption: two field cases. Vet Dermatol 16: 269-275.
  20. Laur N, Kinscherf R, Pomytkin K, Kaiser L, Knes O, Deigner HP. 2020. ICP-MS trace element analysis in serum and whole blood. PLoS One 15: e0233357.
  21. Lee HG, Cho A, Jung YH, Do YJ, Bok EY, Hur TY. 2023. The effect of bovine dermatophytosis on auction price in Hanwoo calves. Korean J vet Serv 46(3): 243-247.
  22. Lu JM, Lin PH, Yao Q, Chen C. 2010. Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems. J Cell Mol Med 14: 840-860.
  23. Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A. 2001. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 19: 683-765.
  24. Nisbet C, Yarim GF, Ciftci G, Arslan HH, Ciftci A. 2006. Effects of trichophytosis on serum zinc levels in calves. Biol Trace Elem Res 113: 273-279.
  25. Otter A. Diagnostic blood biochemistry and haematology in cattle. 2013. In Pract 35:7-16.
  26. Paryuni AD, Indarjulianto S, Widyarini S. 2020. Dermatophytosis in companion animals: A review. Vet World 13: 1174-1181.
  27. Rickard BF. 1975. Facial eczema: zinc responsiveness in dairy cattle. N Z Vet J 23: 41-42.
  28. Rippon JW. 1989. Medical mycology; the pathogenic fungi and the pathogenic actinomycetes. 3rd ed. Philadelphia, USA: WB Saunders Co.
  29. Sezer K, Hanedan B, Ozcelik M, Kirbas A. 2021. Assessment of oxidative stress, trace elements, serum biochemistry, and hormones levels in weaned calves with dermatophytosis. J Hellenic Vet Med Soc 72: 2653-2660.
  30. Spears JW. 2000. Micronutrients and immune function in cattle. Proc Nutr Soc. 59:587-94.
  31. Wintergerst ES, Maggini S, Hornig DH. 2007. Contribution of selected vitamins and trace elements to immune function. Ann Nutr Metab 51: 301-323.