International Journal of Stem Cells

Korean Society for Stem Cell Research (한국줄기세포학회)
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Human Endometrial Regenerative Cells for Neurological Disorders: Hype or Hope?

  • Javad Momeni (Neuroscience Research Center, Mashhad University of Medical Sciences) ;
  • Elnaz Naserzadeh (Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences) ;
  • Ali Sepehrinezhad (Department of Neuroscience, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences) ;
  • Rezan Ashayeri Ahmadabad (Shefa Neuroscience Research Center, Khatam Alanbia Hospital) ;
  • Sajad Sahab Negah (Neuroscience Research Center, Mashhad University of Medical Sciences)
  • Received : 2023.06.15
  • Accepted : 2023.10.06
  • Published : 2024.08.30
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Abstract

Despite enormous efforts, no effective medication has been found to significantly halt or even slow the progression of neurological diseases, such as acquired (e.g., traumatic brain injury, spinal cord injury, etc.) and chronic (e.g., Parkinson's disease, Alzheimer's disease, etc.) central nervous system disorders. So, researchers are looking for alternative therapeutic modalities to manage the disease's symptoms and stop it from worsening. Concerning disease-modifying capabilities, stem cell therapy has emerged as an expanding domain. Among different types of stem cells, human endometrial regenerative cells have excellent regenerative properties, making them suitable for regenerative medicine. They have the potential for self-renewal and differentiation into three types of stem cells: epithelial stem cells, endothelial side population stem cells, and mesenchymal stem cells (MSCs). ERCs can be isolated from endometrial biopsy and menstrual blood samples. However, there is no comprehensive evidence on the effects of ERCs on neurological disorders. Hence, we initially explore the traits of these specific stem cells in this analysis, followed by an emphasis on their therapeutic potential in treating neurological disorders.

Keywords

Acknowledgement

We would like to thank the Clinical Research Development Unit, Imam Reza Hospital, Mashhad University of Medical Sciences, for their assistance in this manuscript.

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