Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Comparison Study on the Blood Acetaldehyde Concentration According to ALDH2 Genotype, Age, Gender

ALDH2 유전자형에 따라 나이, 성별로 나누어 비교한 혈중 아세트알데히드 농도에 관한 연구

  • Byung-Uk Joo (Department of Psychiatry, Pusan National University Yangsan Hospital) ;
  • Ji-Woon Jeong (Department of Psychiatry, Pusan National University Yangsan Hospital) ;
  • Se Ra Choi (Department of Psychiatry, Pusan National University Yangsan Hospital) ;
  • Jung Seok Lee (Department of Psychiatry, Pusan National University Yangsan Hospital) ;
  • Sung Young Huh (Department of Psychiatry, Pusan National University Yangsan Hospital) ;
  • Hyeon-Kyeong Kim (Medical research institute, Pusan National University) ;
  • Sung-Gon Kim (Department of Psychiatry, Pusan National University Yangsan Hospital)
  • 주병욱 (양산부산대학교병원 정신건강의학과) ;
  • 정지운 (양산부산대학교병원 정신건강의학과) ;
  • 최세라 (양산부산대학교병원 정신건강의학과) ;
  • 이정석 (양산부산대학교병원 정신건강의학과) ;
  • 허성영 (양산부산대학교병원 정신건강의학과) ;
  • 김현경 (부산대학교 의생명융합연구원) ;
  • 김성곤 (양산부산대학교병원 정신건강의학과)
  • Received : 2023.09.21
  • Accepted : 2023.10.25
  • Published : 2024.04.30
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Abstract

Objectives Alcohol is metabolized to acetaldehyde by alcohol dehydrogenase enzyme in the liver and then acetaldehyde is metabolized to acetone by aldehyde dehydrogenase (ALDH) in the liver. There are two main ALDH enzymes which metabolize the acetaldehyde produced during ethanol oxidation. In particular, in the presence of the ALDH2 1*2 allele, the activity of the ALDH 2 enzyme is lowered. As a result, acetaldehyde metabolism is slowed down and acetaldehyde accumulates in the body compared to the ALDH2 1*1 allele. There are many studies that have investigated the blood acetaldehyde concentration according to the ALDH2 genotype, but there are few studies to compare this with age. So we investigated the blood acetaldehyde concentration according to ALDH2 genotype, age and gender. Methods According to the ALDH2 genotype, we divided the group by gender and age. We divided the age group in to three groups which ranged from 20 to 34 years old, from 35 to 49 years old, and lastly from 50 to 64 years old. And then we collected blood samples after 15 min, 30 min, 1 hr, 2 hr, 3 hr, 4 hr, 5 hr and 15 hr of after drinking to measure the blood acetaldehyde concentration. Results In ALDH2 1*2 allele group, there are significant differences of the blood acetaldehyde concentration between the age groups. In ALDH2 1*2 allele and male group, there are significant differences of the blood acetaldehyde concentration between the age groups. Conclusions There are significant differences of the blood acetaldehyde concentration between the age groups according to ALDH2 genotype. Also, there are significant differences of the blood acetaldehyde concentration between the age groups with male gender and ALDH2 1*2 allele. Studies about other factors that may influence the blood acetaldehyde concentration are needed.

Keywords

Acknowledgement

This research was supported by a fund (HD16A1569) by Research of Korea Centers for Disease Control and Prevention.

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