한국미생물·생명공학회지 (Microbiology and Biotechnology Letters)

  • 제52권2호
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  • Pages.105-113
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  • 2024
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  • 1598-642X(pISSN)
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  • 2234-7305(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
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The Innate Immune Viral Sensors and Their Functional Crosstalk

  • Ji-Seung Yoo (KNU Institute for Microorganisms, Kyungpook National University)
  • 투고 : 2024.06.02
  • 심사 : 2024.06.05
  • 발행 : 2024.06.28
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초록

The precise and elaborate regulation of signaling cascades by diverse cytoplasmic and endosomal antiviral sensors is crucial for maintaining immune homeostasis and defending against viral pathogens. Receptors and enzymes that recognize foreign nucleic acids play a pivotal role in inducing antiviral interferon programs, serving as the first line of defense against various DNA and RNA viruses. Recent research has increasingly highlighted the crosstalk between nucleic acid sensors in detecting multiple virus invasions, resulting in amplified antiviral signals and compensating for any missing roles. This review provides an update on recent findings regarding the interplay of RNA sensors for DNA virus recognition.

키워드

과제정보

This research(or work) was supported by Kyungpook National University Research Fund, 2023.

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