Nuclear Engineering and Technology

Korean Nuclear Society (한국원자력학회)
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Photon dose response functions for accurate skeletal dosimetry for Korean and Asian populations

  • Bangho Shin (Department of Nuclear Engineering, Hanyang University) ;
  • Chansoo Choi (J. Crayton Pruitt Family, Department of Biomedical Engineering, University of Florida) ;
  • Rui Qiu (Department of Engineering Physics, Tsinghua University) ;
  • Suhyeon Kim (Department of Nuclear Engineering, Hanyang University) ;
  • Hyeonil Kim (Department of Nuclear Engineering, Hanyang University) ;
  • Sungho Moon (Department of Nuclear Engineering, Hanyang University) ;
  • Gahee Son (Department of Nuclear Engineering, Hanyang University) ;
  • Jaehyo Kim (Department of Nuclear Engineering, Hanyang University) ;
  • Haegin Han (Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institute of Health) ;
  • Yeon Soo Yeom (Department of Radiation Convergence Engineering, Yonsei University) ;
  • Chan Hyeong Kim (Department of Nuclear Engineering, Hanyang University)
  • Received : 2023.11.17
  • Accepted : 2024.01.18
  • Published : 2024.06.25
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Abstract

To enhance skeletal dosimetry in conjunction with the adult mesh-type reference Korean phantoms (MRKPs), Korean/Asian photon fluence-to-skeletal dose response functions (DRFs) were established utilizing an updated version of micro-CT-based detailed bone models from Tsinghua University. These bone models were incorporated into the MRKPs using the parallel geometry feature of Geant4. We calculated bone-site-specific electron absorbed fractions and used them to generate DRFs, following a similar methodology employed for ICRP-116 DRFs that have been used with the ICRP reference phantoms for skeletal dosimetry. To assess dosimetric implications of the Korean/Asian DRFs, we calculated RBM and BE doses for the MRKPs exposed to photon beams in the antero-posterior direction using the Korean/Asian and ICRP-116 DRFs. For energies ≥200 keV, the Korean/Asian DRFs-based skeletal doses exhibited excellent agreement with the ICRP-116 DRFs-based skeletal doses, attributed to the existence of charged particle equilibrium across the bone site. Conversely, significant differences of up to ~2.3 times were observed at lower energies, due to differences in the skeletal tissue distributions of bone models used to derive the Korean/Asian and ICRP-116 DRFs. The DRFs established in this study are expected to yield more accurate skeletal doses for Korean and Asian populations compared to the ICRP-116 DRFs.

Keywords

Acknowledgement

This work was supported by the Nuclear Safety Research and Development (NSR&D) Program through the Korea Foundation of Nuclear Safety (KoFONS) funded by the Nuclear Safety and Security Commission (NSSC), by the National Research Foundation of Korea (NRF) grant funded by the Korean government, by the Korea Institute of Energy Technology Evaluation and Planning (KETEP) grant funded by the Korea government (MOTIE), and by the Regional Innovation Strategy (RIS) through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (MOE) (Project Nos.: 2203028, 2022R1C1C100809312, RS-2023-00236726, and 2022RIS-005).

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