Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Plant-Based Decellularization: A Novel Approach for Perfusion-Compatible Tissue Engineering Structures

  • Md Mehedee Hasan (Department of Convergence Biosystems Engineering, College of Agriculture and Life Sciences (CALS), Chonnam National University) ;
  • Ashikur Rahman Swapon (Department of Convergence Biosystems Engineering, College of Agriculture and Life Sciences (CALS), Chonnam National University) ;
  • Tazrin Islam Dipti (Department of Convergence Biosystems Engineering, College of Agriculture and Life Sciences (CALS), Chonnam National University) ;
  • Yeong-Jin Choi (Department of Advanced Biomaterials Research, Korea Institute of Materials Science (KIMS)) ;
  • Hee-Gyeong Yi (Department of Convergence Biosystems Engineering, College of Agriculture and Life Sciences (CALS), Chonnam National University)
  • Received : 2024.01.30
  • Accepted : 2024.02.24
  • Published : 2024.05.28
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Abstract

This study explores the potential of plant-based decellularization in regenerative medicine, a pivotal development in tissue engineering focusing on scaffold development, modification, and vascularization. Plant decellularization involves removing cellular components from plant structures, offering an eco-friendly and cost-effective alternative to traditional scaffold materials. The use of plant-derived polymers is critical, presenting both benefits and challenges, notably in mechanical properties. Integration of plant vascular networks represents a significant bioengineering breakthrough, aligning with natural design principles. The paper provides an in-depth analysis of development protocols, scaffold fabrication considerations, and illustrative case studies showcasing plant-based decellularization applications. This technique is transformative, offering sustainable scaffold design solutions with readily available plant materials capable of forming perfusable structures. Ongoing research aims to refine protocols, assess long-term implications, and adapt the process for clinical use, indicating a path toward widespread adoption. Plant-based decellularization holds promise for regenerative medicine, bridging biological sciences with engineering through eco-friendly approaches. Future perspectives include protocol optimization, understanding long-term impacts, clinical scalability, addressing mechanical limitations, fostering collaboration, exploring new research areas, and enhancing education. Collectively, these efforts envision a regenerative future where nature and scientific innovation converge to create sustainable solutions, offering hope for generations to come.

Keywords

Acknowledgement

This work was supported by the National Research Foundation of Korea (NRF) grants funded by the Korea government (MSIT) (No. NRF-2019R1C1C1009606 and No. 2020R1A5A8018367)). This research was also supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF)& funded by the Korean government (MSIT) (No. NRF-2022M3A9E4017151 & NRF-2022M3A9E4082654). This work was also supported by the Technology Innovation Program (or Industrial Strategic Technology Development Program (20015148) and the Alchemist Project (20012378) funded By the Ministry of Trade, Industry & Energy (MOTIE, Korea). This work was also supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry(IPET) through the Agriculture and Food Convergence Technologies Program for Research Manpower development, funded by Ministry of Agriculture, Food and Rural Affairs(MAFRA)(project no. RS-2024-00397026).

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