Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Salvia miltiorrhiza Bunge Ameliorates Benign Prostatic Hyperplasia through Regulation of Oxidative Stress via Nrf-2/HO-1 Activation

  • Young-Jin Choi (Department of Food Science and Nutrition, Dong-A University) ;
  • Nishala Erandi Wedamulla (Department of Food Science and Nutrition, Dong-A University) ;
  • Seok-Hee Kim (Department of Food Science and Nutrition, Dong-A University) ;
  • Mirae Oh (Grassland and Forages Division, National Institute of Animal Science, Rural Development Administration) ;
  • Kang Sik Seo (Curome Bioscience Co., Ltd.) ;
  • Jeong Su Han (Curome Bioscience Co., Ltd.) ;
  • Eun Joo Lee (Healthism Corporation) ;
  • Young Ho Park (Healthism Corporation) ;
  • Young Jin Park (Department of Family Medicine, Dong-A University College of Medicine) ;
  • Eun-Kyung Kim (Educational Major, Graduate School of Education, Dong-A University)
  • Received : 2023.09.02
  • Accepted : 2023.10.23
  • Published : 2024.05.28
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Abstract

Oxidative stress is a key factor in the pathogenesis of benign prostatic hyperplasia (BPH) that leads to inflammation. This study aimed to evaluate the ameliorative effects of Salvia miltiorrhiza Bunge extract (HLT-101) on BPH through the regulation of oxidative stress and inflammation. A testosterone propionate (TP)-induced BPH rat model was orally administered HLT-101 (20, 40, or 80 mg/kg), and its effects on oxidative stress- and inflammation-related gene expression were examined. Further, HLT-101 was assessed for its effect on reactive oxygen species (ROS) levels and Nrf-2/HO-1 signaling pathways in BPH-1 cells. HLT-101 decreased testosterone-induced excessive free radical production and inflammatory factor activation. Moreover, HLT-101 treatment significantly decreased the intracellular ROS level in the TNF-α and IFN-γ treated BPH-1 cells through the activation of Nrf-2. In addition, HLT-101 treatment inhibited the NF-κB pathway and androgen receptor (AR) signaling, which is highly linked to the pathogenesis of BPH. Therefore, HLT-101 has the potential to be an effective treatment reagent for BPH because of its ability to reduce inflammation and oxidative stress via Nrf-2/HO-1 signaling.

Keywords

Acknowledgement

This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (NRF-2020R1A2C1014798), the Research Program for Agricultural Science & Technology Development (PJ016130), National Academy of Agricultural Science, Rural Development Administration, and the Technology Development Program (S3289574) funded by the Ministry of SMEs and Startups (MSS) Republic of Korea.

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