한국분말재료학회지 (Journal of Powder Materials)

  • 제31권3호
  • /
  • Pages.263-271
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  • 2024
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  • 2799-8525(pISSN)
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  • 2799-8681(eISSN)
한국분말재료학회 (*구 분말야금학회) (The Korean Powder Metallurgy & Materials Institute)
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다양한 고체분산체 제조방법으로 제조한 실로도신 함유 고체분산체의 비교 및 특성분석

Comparison and Characterization of Silodosin-loaded Solid Dispersions Prepared by Various Solid Dispersion Preparation Methods

  • 이수만 (경상국립대학교 제약공학과) ;
  • 송다영 (경상국립대학교 제약공학과) ;
  • 김경수 (경상국립대학교 제약공학과)
  • Su Man Lee (Department of Pharmaceutical Engineering, Gyeongsang National University) ;
  • Da Young Song (Department of Pharmaceutical Engineering, Gyeongsang National University) ;
  • Kyeong Soo Kim (Department of Pharmaceutical Engineering, Gyeongsang National University)
  • 투고 : 2024.05.27
  • 심사 : 2024.06.18
  • 발행 : 2024.06.28
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초록

This study focused on improving the solubility of silodosin, a drug poorly soluble in water, by utilizing solid dispersions. Three types of dispersions were examined and compared against the drug powder: surface-attached (SA), solvent-wetted (SW), and solvent-evaporated (SE). Polyvinyl alcohol (PVA) was identified as the most effective polymer in enhancing solubility. These dispersions were prepared using spray-drying techniques with silodosin and PVA as the polymer, employing solvents such as water, ethanol, and a water-acetone mix. The physicochemical properties and solubility of the dispersions were evaluated. The surface-attached dispersions featured the polymer on a crystalline drug surface, the solvent-wetted dispersions had the amorphous drug on the polymer, and the solvent-evaporated dispersions produced nearly round particles with both components amorphous. Testing revealed that the order of improved solubility was: solvent-evaporated, solvent-wetted, and surface-attached. The results demonstrated that the preparation method of the solid dispersions significantly impacted their physicochemical properties and solubility enhancement.

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과제정보

이 연구는 2024년도 경상국립대학교 발전기금재단 재원으로 수행되었음.

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