한국식생활문화학회지 (Journal of the Korean Society of Food Culture)

  • 제39권1호
  • /
  • Pages.74-81
  • /
  • 2024
  • /
  • 1225-7060(pISSN)
  • /
  • 2288-7148(eISSN)
한국식생활문화학회 (Korean Society of Food Culture)
권호 표지
DOI QR코드

DOI QR Code

리보플라빈의 염증성 장질환 개선 효과

Beneficial Effects of Riboflavin on Inflammatory Bowel Disease

  • 이상희 (한국식품연구원) ;
  • 홍선미 (환동해산업연구원) ;
  • 성미정 (한국식품연구원)
  • Sang Hee Lee (Korea Food Research Institute) ;
  • Sun Mi Hong (Marine Industry Research Institute for East Sea Rim) ;
  • Mi Jeong Sung (Korea Food Research Institute)
  • 투고 : 2024.01.17
  • 심사 : 2024.02.22
  • 발행 : 2024.02.29
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Ulcerative colitis (UC) is a chronic inflammatory intestinal disease characterized by an imbalance in immune function and the overexpression of inflammatory cytokines and mediators. Vitamin B2, also known as riboflavin (Libof), is an essential water-soluble vitamin with numerous beneficial properties, including antioxidant, anti-aging, anti-inflammatory, anti-nociceptive, and anti-cancer effects. In this study, we aimed to investigate the protective effects of Libof on dextran sulfate sodium (DSS)-induced experimental colitis. The C57BL/6 mice were used as the in vivo model of chronic colitis to investigate the anti-inflammatory effects of Libof. RAW 264.7 cells were used for the in vitro investigation of the molecular mechanisms underlying these effects. In vivo, Libof alleviated the DSS-induced disease activity index (DAI), colon length shortening, and colonic pathological damage. In vitro, Libof inhibited lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 production in RAW 264.7 cells. Moreover, Libof inhibited LPS-induced nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells. In conclusion, these findings indicate that Libof shows potential as an agent for the treatment of UC.

키워드

과제정보

본 연구는 한국식품연구원의 기본사업(E0210102-03)과 정부수탁연구사업(GA121047 and GA122055)의 지원을 받아 연구되었습니다.

참고문헌

  1. Baumgart DC, Carding SR. 2007. Inflammatory bowel disease: cause and immunobiology. Lancet, 369:1627-1640 
  2. Buehler BA. 2011. Vitamin B2: Riboflavin. J. Evid. Based. Complementary Altern. Med., 16:88-90 
  3. Chassaing B, Aitken JD, Malleshappa M, Vijay-Kumar M. 2014. Dextran sulfate sodium (DSS)-induced colitis in mice. Curr. Protoc. Imunol., 104: Unit 15.25 
  4. Chen YE, Xu SJ, Lu YY, Chen SX, Du XH, Hou SZ, Huang HY, Liang J. 2021. Asperuloside suppressing oxidative stress and inflammation in DSS-induced chronic colitis and raw264.7 macrophages via Nrf2/HO-1 and NF-?B pathway. Chem. Ciol. Interact., 344:109512 
  5. Jeon YD, Lee JH, Kang SH, Myung H, Jin JS. 2021. Lingonberry fruit ethanol extract ameliorates DSS-induced ulcerative colitis in vivo and in vitro. Appl. Sci., 11(17):7995 
  6. Jing Y, Liu H, Xu W, Yang Q. 2017. Amelioration of the DSS-induced colitis in mice by pretreatment with 4,4'-diaponeurosporene-producing Bacillus subtilis. Exp. Ther. Med., 14:6069-6073 
  7. Kwak MS, Cha JM, Lee HH, Choi YS, Seo SI, Ko KJ, Park DI, Kim SH, Kim TJ. 2019. Emerging trends of inflammatory bowel disease in South Korea: a nationwide population-based study. J. Gastroenterol. Hepatol., 34: 1018-1026 
  8. Levit R, Savoy de Giori G, de Moreno de LeBlanc A, LeBlanc JG. 2018. Effect of riboflavin-producing bacteria against chemically induced colitis in mice. J. Appl. Microbiol., 124:232-40 
  9. Lin X, Guo X, Qu L, Tu J, Li S, Cao G, Liu Y. 2022. Preventive effect of Atractylodis Rhizoma extract on DSS-induced acute ulcerative colitis through the regulation of the MAPK/NF-κB signals in vivo and in vitro. J. Ethnopharmocol., 292:115211 
  10. Menezes RR, Godin AM, Rodrigues FF, Coura GME, Melo IS, Brito AMS, Bertollo CM, Paulino TP, Rachid MA, Machado RR, Coelho MM. 2017. Thiamine and riboflavin inhibit production of cytokines and increase the anti-inflammatory activity of a corticosteroid in a chronic model of inflammation induced by complete Freund's adjuvant. Pharmacol. Rep., 69:1036-43 
  11. Nagata J, Yokodera H, Meada G. 2019. In Vitro and in Vivo Studies on Anti-Inflammatory Effects of Traditional Okinawan Vegetable Methanol Extracts. ACS Omega, 4(13):15660-15664 
  12. Ng WK, Wong SH, Ng SC. 2016. Changing epidemiological trends of inflammatory bowel disease in Asia. Intest. Res., 14:111-119 
  13. Oh SY, Cho KA, Kang JL, Kim KH, Woo SY. International. 2013. Comparison of experimental mouse models of inflammatory bowel disease. J. Mol. Med., 33:333-340 
  14. Peng L, Gao X, Nie L, Xie J, Dai T, Shi C, Tao L, Wang Y, Tian Y, Sheng J. 2020. Astragalin attenuates dextran sulfate sodium (DSS)-induced acute experimental colitis by alleviating gut microbiota dysbiosis and inhibiting NF-κB activation in mice. Front. Immunol., 11:2058 
  15. Ramos GP, Papadakis KA. 2019. Mechanisms of Disease: Inflammatory Bowel Diseases. Mayo. Clin. Proc., 94: 155-165 
  16. Son SJ, Han AR, Sung MJ, Hong SM, Lee SH. 2023. Hermetia illucens Fermented with Lactobacillus plantarum KCCM12757P Alleviates Dextran Sodium Sulfate-Induced Colitis in Mice. Antioxid., 12,1822 
  17. Susana SF, L. Sanchez DI, Cardeno A, Alarcon de la Lastra C. 2012. Influence of extra virgin olive oil diet enriched with hydroxytyrosol in a chronic DSS colitis model, Eur. J. Nutr., 51:497-506 
  18. Wan Z, Zheng J, Zhu Z, Sang L, Zhu J, Luo S, Zhao Y, Wang R, Zhang Y, Hao K, Chen L, Du J, Kan J, He H. 2022. Intermediate role of gut microbiota in vitamin B nutrition and its influences on human health. Front. Nutr., 9: 1031502 
  19. Xing L, Fu L, Cao S, Yin Y, Wei L, Zhang W. 2022. The anti-inflammatory effect of bovine bone-gelatin-derived peptides in LPS-induced RAW264.7 macrophages cells and dextran sulfate sodium-induced C57BL/6 mice. Nutr., 14:1479
  20. Yang BM, Ahn SH, Kim KB. 2021. The Anti-Inflammatory Effect of Duchi extract on Ulcerative Colitis, 35(1): 30-39
  21. Yang Y, Owyang C, Wu GD. 2016. East meets west: the increasing incidence of inflammatory bowel disease in asia as a paradigm for environmental effects on the pathogenesis of immunemediated disease. Gastroenterol., 151:e1-e5