Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
권호 표지
DOI QR코드

DOI QR Code

A Case of Inoperable Advanced Papillary Thyroid Carcinoma Maintaining Long-term Stable Disease State after Palliative Aim Radiation Therapy Alone

수술이 불가능하여 고식적 목적의 외부방사선 단독치료 후 장기 안정병변 상태를 유지하고 있는 진행된 갑상선 유두암 1예

  • Tae Hyun Kim (Department of Radiation Oncology, Seoul National University College of Medicine) ;
  • Hong Gyun Wu (Department of Radiation Oncology, Seoul National University College of Medicine)
  • 김태현 (서울대학교 의과대학 방사선종양학 교실) ;
  • 우홍균 (서울대학교 의과대학 방사선종양학 교실)
  • Received : 2023.07.19
  • Accepted : 2023.09.11
  • Published : 2024.05.30
Download PDF
⟨ Previous Next ⟩

Abstract

The current standard of treatment for differentiated thyroid cancer is surgical resection followed by radioactive iodine therapy according to the recurrence risk. However, external beam radiotherapy may be recommended in limited cases where surgical resection is impossible or residual gross lesion remains or the aforementioned standard therapy is deemed insufficient in achieving local control. We report a case of 59 year old patient who presented with advanced papillary thyroid carcinoma of right neck but was unable to receive surgical resection due to underlying Eisenmenger syndrome. He received radiation therapy of 67.5 Gy in 30 fractions with palliative aim with no further treatment and has been maintaining long-term stable disease state for 38 months. Herein, we report a rare case of palliative aim radiation therapy alone for advanced papillary thyroid carcinoma with literature review.

Keywords

References

  1. Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, et al. 2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid. 2016;26:1-133. https://doi.org/10.1089/thy.2015.0020
  2. Kiess AP, Agrawal N, Brierley JD, Duvvuri U, Ferris RL, Genden E, et al. External-beam radiotherapy for differentiated thyroid cancer locoregional control: A statement of the American Head and Neck Society. Head Neck. 2016;38:493-498. https://doi.org/10.1002/HED.24357
  3. Yi KH, Lee EK, Kang H-C, Koh Y, Kim SW, Kim IJ, et al. 2016 Revised Korean thyroid association management guidelines for patients with thyroid nodules and thyroid cancer. Int J Thyroidol. 2016;9:59-126.
  4. Tsang RW, Brierley JD, Simpson WJ, Panzarella T, Gospodarowicz MK, Sutcliffe SB, et al. The effects of surgery, radioiodine, and external radiation therapy on the clinical outcome of patients with differentiated thyroid carcinoma. Cancer. 1998;82:375-388.
  5. Meadows KM, Amdur RJ, Morris CG, Villaret DB, Mazzaferri EL, Mendenhall WM. External beam radiotherapy for differentiated thyroid cancer. Am J Otolaryngol. 2006;27(Supply 9): 24-28. https://doi.org/10.1016/J.AMJOTO.2005.05.017
  6. Tubiana M, Haddad E, Schlumberger M, Hill C, Rougier P, Sarrazin D. External radiotherapy in thyroid cancers. Cancer. 1985;55: 2062-2071. https://doi.org/10.1002/1097-0142(19850501)55:9+<2062::AID-CNCR2820551406>3.0.CO;2-O
  7. Biermann M, Pixberg MK, Riemann B, Schuck, A, Heinecke, A, Schmid, KW, et al. Clinical outcomes of adjuvant external-beam radiotherapy for differentiated thyroid cancer: Results after 874 patient-years of follow-up in the MSDS-trial. NuklearMedizin. 2009;48:89-98. https://doi.org/10.3413/NUKMED-0221/ID/JR0221-29
  8. Chow SM, Law SCK, Mendenhall WM, AU S-K, Chan PTM, Leung T-W, et al. Papillary thyroid carcinoma: prognostic factors and the role of radioiodine and external radiotherapy. Int J Radiat Oncol. 2002;52:784-795. https://doi.org/10.1016/S0360-3016(01)02686-4
  9. Fussey JM, Crunkhorn R, Tedla M, Weickert MO, Mehanna H. External beam radiotherapy in differentiated thyroid carcinoma: A systematic review. Head Neck. 2016;38(Supply 1):E2297-E23 05. https://doi.org/10.1002/HED.24218
  10. Chow SM, Yau S, Kwan CK, Poon PCM, Law SCK. Local and regional control in patients with papillary thyroid carcinoma: Specific indications of external radiotherapy and radioactive iodine according to T and N categories in AJCC 6th edition. Endocr Relat Cancer. 2006;13:1159-1172. https://doi.org/10.1677/ERC.1.01320
  11. Ford D, Giridharan S, McConkey C, Hartley A, Brammer C, Watkinson JC, et al. External beam radiotherapy in the management of differentiated thyroid cancer. Clin Oncol. 2003;15:337-341. https://doi.org/10.1016/S0936-6555(03)00162-6
  12. Terezakis SA, Lee KS, Ghossein RA, Rivera M, Tuttle RM, Wolden SL, et al. Role of external beam radiotherapy in patients with advanced or recurrent nonanaplastic thyroid cancer: Memorial Sloan-Kettering cancer center experience. Int J Radiat Oncol Biol Phys. 2009;73:795-801. https://doi.org/10.1016/j.ijrobp.2008.05.012
  13. Schwartz DL, Lobo MJ, Ang KK, Morrison WH, Rosenthal DI, Ahamad A, et al. Postoperative external beam radiotherapy for differentiated thyroid cancer: Outcomes and morbidity with conformal treatment. Int J Radiat Oncol Biol Phys. 2009;74:1083-1091. https://doi.org10.1016/j.ijrobp.2008.09.023