Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Amomum Villosum Extracts on Cholesterol Synthesis in HepG2 Cells

양춘사 추출물이 HepG2 세포에서 콜레스테롤 합성에 미치는 효과

  • Ha Rim Kim (Department of Physiology, School of Korean Medicine, Wonkwang University & Ilwonbio Co. Ltd.) ;
  • Ye Seul Kim (Department of Physiology, School of Korean Medicine, Wonkwang University & Ilwonbio Co. Ltd.) ;
  • Han Byeol Choi (Department of Physiology, School of Korean Medicine, Wonkwang University & Ilwonbio Co. Ltd.) ;
  • Su Hyeon Woo (Department of Physiology, School of Korean Medicine, Wonkwang University & Ilwonbio Co. Ltd.) ;
  • Kang Beom Kwon (Department of Physiology, School of Korean Medicine, Wonkwang University & Ilwonbio Co. Ltd.)
  • 김하림 (원광대학교 한의과대학 생리학교실 및 (주)일원바이오) ;
  • 김예슬 (원광대학교 한의과대학 생리학교실 및 (주)일원바이오) ;
  • 최한별 (원광대학교 한의과대학 생리학교실 및 (주)일원바이오) ;
  • 우수현 (원광대학교 한의과대학 생리학교실 및 (주)일원바이오) ;
  • 권강범 (원광대학교 한의과대학 생리학교실 및 (주)일원바이오)
  • Received : 2024.01.23
  • Accepted : 2024.02.23
  • Published : 2024.02.25
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Abstract

Dried fruits of Amomum villosum Lour. have been used an korean medicine to treat digestive diseases for a long time. It has been reported that Amomum villosum extracts(AVE) have effects for diabetes and steatosis in experimental models. But we did not find the report about the cholesterol synthesis inhibition effects of AVE. The objective of this study is to clarify the inhibitory effect of AVE against oleic acid and glucose-induced hypercholesterolemia in HepG2 cells. The results show that AVE had a significant inhibitory effect against oleic acid and glucose-induced cholesterol accumulation. Those effects seem to be caused by inhibition of AVE on oleic acid and glucose-induced decrease of HMG CoA reductase, which is the rate-limiting enzyme for cholesterol biosynthesis in liver. It is believed that the results of this study can provide basic data for the drug and functional food development of hypercholesterolemia treatments.

Keywords

Acknowledgement

본 연구는 2020년도 중소벤처기업부의 중소기업기술개발사업 지원에 의한 연구임 (Project No. S2853447).

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