Journal of Yeungnam Medical Science

영남대 의대 학술지 편집위원회 (Yeungnam University College of Medicine, Yeungnam University Institute Medical Science)
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Comprehensive overview of the role of mitochondrial dysfunction in the pathogenesis of acute kidney ischemia-reperfusion injury: a narrative review

  • Min-Ji Kim (Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital) ;
  • Chang Joo Oh (Research Institute of Aging and Metabolism, School of Medicine, Kyungpook National University) ;
  • Chang-Won Hong (Department of Physiology, School of Medicine, Kyungpook National University) ;
  • Jae-Han Jeon (Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital)
  • 투고 : 2023.12.09
  • 심사 : 2024.01.10
  • 발행 : 2024.04.30
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초록

Acute kidney ischemia-reperfusion (IR) injury is a life-threatening condition that predisposes individuals to chronic kidney disease. Since the kidney is one of the most energy-demanding organs in the human body and mitochondria are the powerhouse of cells, mitochondrial dysfunction plays a central role in the pathogenesis of IR-induced acute kidney injury. Mitochondrial dysfunction causes a reduction in adenosine triphosphate production, loss of mitochondrial dynamics (represented by persistent fragmentation), and impaired mitophagy. Furthermore, the pathological accumulation of succinate resulting from fumarate reduction under oxygen deprivation (ischemia) in the reverse flux of the Krebs cycle can eventually lead to a burst of reactive oxygen species driven by reverse electron transfer during the reperfusion phase. Accumulating evidence indicates that improving mitochondrial function, biogenesis, and dynamics, and normalizing metabolic reprogramming within the mitochondria have the potential to preserve kidney function during IR injury and prevent progression to chronic kidney disease. In this review, we summarize recent advances in understanding the detrimental role of metabolic reprogramming and mitochondrial dysfunction in IR injury and explore potential therapeutic strategies for treating kidney IR injury.

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과제정보

This research was supported by Kyungpook National University Development Project Research Fund, 2020.

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