DOI QR코드

DOI QR Code

Evaluation of the Remineralization Capacity of Water-based Silver Fluoride

  • Gwangsuk Kim (Department of Pediatric Dentistry, Oral Science Research Center, College of Dentistry, Gangneung-Wonju National University) ;
  • Juhyun Lee (Department of Pediatric Dentistry, Oral Science Research Center, College of Dentistry, Gangneung-Wonju National University) ;
  • Haeni Kim (Department of Pediatric Dentistry, Oral Science Research Center, College of Dentistry, Gangneung-Wonju National University)
  • Received : 2023.11.17
  • Accepted : 2023.12.02
  • Published : 2024.02.29

Abstract

Silver diamine fluoride, which can arrest dental caries, is alkaline and may cause mild soft tissue irritation. Water-based silver fluoride has a neutral pH, which is closer to the physiological range, and is biocompatible for use in the oral environment. This study aimed to evaluate the effect of water-based silver fluoride on remineralizing early enamel lesions by comparing it with other fluoride agents through microhardness and quantitative light-induced fluorescence measurements. An in vitro study with intact bovine incisors was performed. Artificial enamel lesions were induced and subjected to microhardness and quantitative light-induced fluorescence testing. Specimens were randomly divided into 4 groups for treatment. The specimens in group I were treated with water-based silver fluoride and potassium iodide, group II with silver diamine fluoride and potassium iodide, group III with sodium fluoride varnish, and group IV with distilled water. After 8 days of pH cycling, the specimens were subjected to microhardness and quantitative light-induced fluorescence testing. Water-based silver fluoride and silver diamine fluoride showed the greatest increases in microhardness and quantitative light-induced fluorescence, with no significant differences between the two. Sodium fluoride varnish also exhibited a significant increase in microhardness and quantitative light-induced fluorescence, but the differences were smaller than those for water-based silver fluoride and silver diamine fluoride. Water-based silver fluoride is considered useful in a clinical setting for remineralizing enamel lesions, with the advantages of no risk of tissue burn and improved taste and smell.

Keywords

References

  1. Johansson I, Holgerson PL, Kressin NR, Nunn ME, Tanner AC : Snacking habits and caries in young children. Caries Res, 44:421-430, 2010. 
  2. Oliveira P, Fonseca A, Silva EM, Coutinho T, Tostes MA : Remineralizing potential of CPP-ACP creams with and without fluoride in artificial enamel lesions. Aust Dent J, 61:45-52, 2016. 
  3. Rao SK, Bhat GS, Aradhya S, Devi A, Bhat M : Study of the efficacy of toothpaste containing casein phosphopeptide in the prevention of dental caries: a randomized controlled trial in 12- to 15-year-old high caries risk children in Bangalore, India. Caries Res, 43:430-435, 2009. 
  4. Tufekci E, Dixon JS, Gunsolley JC, Lindauer SJ : Prevalence of white spot lesions during orthodontic treatment with fixed appliances. Angle Orthod, 81:206-210, 2011. 
  5. Huang GJ, Roloff-Chiang B, Mills BE, Shalchi S, Spiekerman C, Korpak AM, Starrett JL, Greenlee GM, Drangsholt RJ, Matunas JC : Effectiveness of MI Paste Plus and PreviDent fluoride varnish for treatment of white spot lesions: a randomized controlled trial. Am J Orthod Dentofacial Orthop, 143:31-41, 2013. 
  6. Ogaard B : White spot lesions during orthodontic treatment: mechanisms and fluoride preventive aspects. Semin Orthod, 14:183-193, 2008. 
  7. de Sousa Mda L, Wagner M, Sheiham A : Caries reductions related to the use of fluorides: a retrospective cohort study. Int Dent J, 52:315-320, 2002. 
  8. Haiat A, Ngo HC, Samaranayake LP, Fakhruddin KS : The effect of the combined use of silver diamine fluoride and potassium iodide in disrupting the plaque biofilm microbiome and alleviating tooth discoloration: A systematic review. PLoS One, 16:E0252734, 2021. 
  9. Chu CH, Lo EC : Microhardness of dentine in primary teeth after topical fluoride applications. J Dent, 36:387-391, 2008. 
  10. Mei ML, Ito L, Cao Y, Lo EC, Li QL, Chu CH : An ex vivo study of arrested primary teeth caries with silver diamine fluoride therapy. J Dent, 42:395-402, 2014. 
  11. Arends J, ten Bosch JJ : Demineralization and remineralization evaluation techniques. J Dent Res, 71:924-928, 1992. 
  12. Cho KH, Kang CM, Jung HI, Lee TY, Song JS : Assessment of the Caries Detection Ability of Quantitative Light-induced Fluorescence (QLF) in Primary Teeth in vitro. J Korean Acad Pediatr Dent, 49:65-75, 2022. 
  13. Lee KH, Ahn JY, Kim JS, Han MR, Lee JH, Shin JS : Effect of Sodium Fluoride Varnish and Potassium Iodide on Remineralization Efficacy of Silver Diamine Fluoride. J Korean Acad Pediatr Dent, 48:467-475, 2021. 
  14. Horst JA, Ellenikiotis H, Milgrom PL : UCSF Protocol for Caries Arrest Using Silver Diamine Fluoride: Rationale, Indications and Consent. J Calif Dent Assoc, 44:16-28, 2016. 
  15. SDI : Riva star aqua. Available from URL: https://www.sdi.com.au/pdfs/brochures/en-gb/riva%20star_sdi_brochures_en-gb.pdf (Accessed on November 15, 2023). 
  16. SDI : Riva star. Available from URL: https://www.sdi.com.au/pdfs/brochures/en-gb/riva%20star_sdi_brochures_en-gb.pdf, (Accessed on November 15, 2023). 
  17. Yu OY, Mei ML, Zhao IS, Li QL, Lo EC, Chu CH : Remineralisation of enamel with silver diamine fluoride and sodium fluoride. Dent Mater, 34:E344-E352, 2018. 
  18. Lee KE, Erdenebulgan M, Kang CM, Jung HI, Song JS : Effect of Silver Diamine Fluoride and Potassium Iodide Solution on Enamel Remineralization and Discoloration in Artificial Caries. Materials (Basel), 15:4523, 2022. 
  19. Kaur S, Bhola M, Bajaj N, Brar GS : Comparative Evaluation of the Remineralizing Potential of Silver Diamine Fluoride, Casein Phosphopeptide-amorphous Calcium Phosphate, and Fluoride Varnish on the Enamel Surface of Primary and Permanent Teeth: An In Vitro Study. Int J Clin Pediatr Dent, 16(Suppl 1):S91-S96, 2023. 
  20. Restorative dentistry : How to Use a Next-Generation Water-Based Solution for Arresting Caries. Available from URL: https://www.sdi.com.au/wp-content/uploads/2021/04/2021-August-Jarod-Johnson-DPR-RivaStar-Aqua.pdf (Accessed on November 17, 2023). 
  21. Zhao IS, Gao SS, Hiraishi N, Burrow MF, Duangthip D, Mei ML, Lo EC, Chu CH : Mechanisms of silver diamine fluoride on arresting caries: a literature review. Int Dent J, 68:67-76, 2018. 
  22. Yan IG, Zheng FM, Yin IX, Sun IG, Lo ECM, Chu CH : Stability of Silver and Fluoride Contents in Silver Diamine Fluoride Solutions. Int Dent J, 73:840-846, 2023. 
  23. Lee HS, An SY : Antibacterial Effects of Silver Fluoride and Difluorosilane-based Varnish on Streptococcus mutans. J Korean Acad Pediatr Dent, 49:497-504, 2022. 
  24. Grawish ME, Grawish LM, Grawish HM, Grawish MM, Holiel AA, Sultan N, El-Negoly SA : Demineralized Dentin Matrix for Dental and Alveolar Bone Tissues Regeneration: An Innovative Scope Review. Tissue Eng Regen Med, 19:687-701, 2022. 
  25. Beniash E, Stifler CA, Sun CY, Jung GS, Qin Z, Buehler MJ, Gilbert PUPA : The hidden structure of human enamel. Nat Commun, 10:4383, 2019. 
  26. Naumova EA, Niemann N, Aretz L, Arnold WH : Effects of different amine fluoride concentrations on enamel remineralization. J Dent, 40:750-755, 2012. 
  27. Altenburger MJ, Schirrmeister JF, Lussi A, Klasser M, Hellwig E : In situ fluoride retention and remineralization of incipient carious lesions after the application of different concentrations of fluoride. Eur J Oral Sci, 117:58-63, 2009. 
  28. Denbio : Nt Clear Varnish. Available from URL: http://www.denbio.com/ko/bbs/content.php?co_id=product01_01 (Accessed on November 20, 2023).