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Prevalence of Dental Anomalies in Patients with Non-syndromic Cleft Lip with or without Cleft Palate

  • Jisu Oh (Department of Pediatric Dentistry, Seoul Asan Medical Center) ;
  • Soyeon Bak (Department of Pediatric Dentistry, Seoul Asan Medical Center) ;
  • Hyeonheon Lee (Department of Pediatric Dentistry, Seoul Asan Medical Center)
  • Received : 2023.11.03
  • Accepted : 2023.11.28
  • Published : 2024.02.29

Abstract

This study aimed to assess the prevalence and distribution pattern of dental anomalies in the permanent teeth of patients with non-syndromic cleft lip with or without cleft palate. Additionally, it aimed to compare differences in dental anomalies between cleft and non-cleft areas, considering gender and cleft phenotype. Panoramic radiographs of 164 patients diagnosed with non-syndromic orofacial clefts were retrospectively analyzed by a single examiner to confirm dental anomalies. The dental anomalies investigated included tooth agenesis, supernumerary teeth, microdontia, rotation, ectopic eruption, and enamel hypoplasia. Cleft phenotypes were categorized into 7 types based on medical and dental records. A significantly higher prevalence of supernumerary teeth was observed in males than females within non-cleft areas (p = 0.017), with no significant differences in other dental anomalies. In non-cleft area, patients with cleft palate exhibited a high prevalence of tooth agenesis (p < 0.0001) and microdontia (p = 0.012) compared to other cleft phenotypes. Maxillary incisor rotation was closely associated with adjacent tooth agenesis in unilateral cleft lip and palate cases (p = 0.034). This study suggests that the additional subphenotype based on dental anomalies in patients with orofacial cleft may serve as applicable clinical markers.

Keywords

References

  1. Lidral AC, Moreno LM, Bullard SA : Genetic factors and orofacial clefting. Semin Orthod, 14:103-114, 2008. https://doi.org/10.1053/j.sodo.2008.02.002
  2. Jaruratanasirikul S, Chichareon V, Pattanapreechawong N, Sangsupavanich P : Cleft lip and/or palate: 10 years experience at a pediatric cleft center in Southern Thailand. Cleft Palate Craniofac J, 45:597-602, 2008. https://doi.org/10.1597/07-176.1
  3. Mossey PA, Little J, Munger RG, Dixon MJ, Shaw WC : Cleft lip and palate. Lancet, 374:1773-1785, 2009. https://doi.org/10.1016/S0140-6736(09)60695-4
  4. Lee CW, Hwang SM, Lee YS, Kim MA, Seo K : Prevalence of orofacial clefts in Korean live births. Obstet Gynecol Sci, 58:196-202, 2015. https://doi.org/10.5468/ogs.2015.58.3.196
  5. Salari N, Darvishi N, Heydari M, Bokaee S, Darvishi F, Mohammadi M : Global prevalence of cleft palate, cleft lip and cleft palate and lip: A comprehensive systematic review and meta-analysis. J Stomatol Oral Maxillofac Surg, 123:110-120, 2022. https://doi.org/10.1016/j.jormas.2021.05.008
  6. Dixon MJ, Marazita ML, Beaty TH, Murray JC : Cleft lip and palate: understanding genetic and environmental influences. Nat Rev Genet, 12:167-178, 2011. https://doi.org/10.1038/nrg2933
  7. da Silva APRB, Costa B, de Carvalho Carrara CF : Dental anomalies of number in the permanent dentition of patients with bilateral cleft lip: radiographic study. Cleft Palate Craniofac J, 45:473-476, 2008. https://doi.org/10.1597/06-099.1
  8. Vyas T, Gupta P, Kumar S, Gupta R, Gupta T, Singh HP : Cleft of lip and palate: A review. J Family Med Prim Care, 9:2621-2625, 2020. https://doi.org/10.4103/jfmpc.jfmpc_472_20
  9. Honein MA, Rasmussen SA, Reefhuis J, Romitti PA, Lammer EJ, Sun L, Correa A : Maternal smoking and environmental tobacco smoke exposure and the risk of orofacial clefts. Epidemiology, 18:226-233, 2007. https://doi.org/10.1097/01.ede.0000254430.61294.c0
  10. Wilcox AJ, Lie RT, Solvoll K, Taylor J, McConnaughey DR, Abyholm F, Vindenes H, Vollset SE, Drevon CA : Folic acid supplements and risk of facial clefts: national population based case-control study. BMJ , 334:464, 2007.
  11. Ardinger HH, Buetow KH, Bell GI, Bardach J, VanDemark DR, Murray JC : Association of genetic variation of the transforming growth factor-alpha gene with cleft lip and palate. Am J Hum Genet, 45:348-353, 1989.
  12. Phan M, Conte F, Khandelwal KD, Ockeloen CW, Bartzela T, Kleefstra T, van Bokhoven H, Rubini M, Zhou H, Carels C : Tooth agenesis and orofacial clefting: genetic brothers in arms? Hum Genet, 135:1299-1327, 2016. https://doi.org/10.1007/s00439-016-1733-z
  13. Leslie EJ, Marazita ML : Genetics of cleft lip and cleft palate. Am J Med Genet C Semin Med Genet, 163:246-258, 2013. https://doi.org/10.1002/ajmg.c.31381
  14. Akcam MO, Evirgen S, Uslu O, Memikoglu UT : Dental anomalies in individuals with cleft lip and/or palate. Eur J Orthod, 32:207-213, 2010. https://doi.org/10.1093/ejo/cjp156
  15. Camporesi M, Baccetti T, Marinelli A, Defraia E, Franchi L : Maxillary dental anomalies in children with cleft lip and palate: a controlled study. Int J Paediatr Dent, 20:442-450, 2010. https://doi.org/10.1111/j.1365-263X.2010.01063.x
  16. Tannure PN, Oliveira CAG, Maia LC, Vieira AR, Granjeiro JM, de Castro Costa M : Prevalence of dental anomalies in nonsyndromic individuals with cleft lip and palate: a systematic review and meta-analysis. Cleft Palate Craniofac J, 49:194-200, 2012. https://doi.org/10.1597/10-043
  17. Letra A, Menezes R, Granjeiro JM, Vieira AR : Defining subphenotypes for oral clefts based on dental development. J Dent Res, 86:986-991, 2007. https://doi.org/10.1177/154405910708601013
  18. Menezes R, Vieira AR : Dental anomalies as part of the cleft spectrum. Cleft Palate Craniofac J, 45:414-419, 2008. https://doi.org/10.1597/07-064.1
  19. Johnson RL, Rothman AL, Xie J, Goodrich LV, Bare JW, Bonifas JM, Quinn AG, Myers RM, Cox DR, Epstein EH Jr, Scott MP : Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science, 272:1668-1671, 1996. https://doi.org/10.1126/science.272.5268.1668
  20. Garvey MT, Barry HJ, Blake M : Supernumerary teeth - an overview of classification, diagnosis and management. J Can Dent Assoc, 65:612-616, 1999.
  21. Stevenson RE, Hall JG : Human malformations and related anomalies, 2nd ed. Oxford University Press, New York, 446, 2005.
  22. Yezioro-Rubinsky S, Eslava-Schmalbach JH, Otero L, Rodriguez-Aguirre SA, Duque AM, Campos FM, Gomez JP, Gomez-Arango S, Posso-Moreno SL, Rojas NE, Garzon-Orjuela N : Dental anomalies in permanent teeth associated with nonsyndromic cleft lip and palate in a group of Colombian children. Cleft Palate Craniofac J, 57:73-79, 2020. https://doi.org/10.1177/1055665619861498
  23. Toutountzakis N, Katsaris N : Ectopic eruption of the maxillary first permanent molar. Orthod Epitheor, 2:117-128, 1990.
  24. Shapira Y, Kuftinec MM, Stom D : Maxillary canine-lateral incisor transposition - orthodontic management. Am J Orthod Dentofacial Orthop, 95:439-444, 1989. https://doi.org/10.1016/0889-5406(89)90306-5
  25. Vieira AR : Oral clefts and syndromic forms of tooth agenesis as models for genetics of isolated tooth agenesis. J Dent Res, 82:162-165, 2003. https://doi.org/10.1177/154405910308200303
  26. Paradowska-Stolarz A, Dubowik M, Szelag J, Kawala B : Dental anomalies in the incisor-canine region in patients with cleft lip and palate - literature review. Dev Period Med, 18:66-69, 2014.
  27. Nagase Y, Natsume N, Kato T, Hayakawa T : Epidemiological analysis of cleft lip and/or palate by cleft pattern. J Maxillofac Oral Surg, 9:389-395, 2010. https://doi.org/10.1007/s12663-010-0132-6
  28. Kim NY, Baek SH : Cleft sidedness and congenitally missing or malformed permanent maxillary lateral incisors in Korean patients with unilateral cleft lip and alveolus or unilateral cleft lip and palate. Am J Orthod Dentofacial Orthop, 130:752-758, 2006. https://doi.org/10.1016/j.ajodo.2005.02.029
  29. Baek SH, Moon HS, Yang WS : Cleft type and Angle' s classification of malocclusion in Korean cleft patients. Eur J Orthod, 24:647-653, 2002. https://doi.org/10.1093/ejo/24.6.647
  30. Hirayama K : Anatomical studies on the development of the facial artery and its distribution in the cleft lip of the human fetus. Part 1 development of the facial artery in the human fetus on the latter stage of pregnancy. Med J Kagoshima Univ, 1:295-316, 1971.
  31. Menezes C, de Arruda JA, Silva LV, Monteiro JL, Caribe P, Alvares P, Almeida MC, Coelli JC, Goldemberg F, Silveira M, Sobral AP, Bueno DF : Nonsyndromic cleft lip and/or palate: A multicenter study of the dental anomalies involved. J Clin Exp Dent, 10:E746-E750, 2018. https://doi.org/10.4317/jced.54926
  32. Tortora C, Meazzini MC, Garattini G, Brusati R : Prevalence of abnormalities in dental structure, position, and eruption pattern in a population of unilateral and bilateral cleft lip and palate patients. Cleft Palate Craniofac J, 45:154-162, 2008. https://doi.org/10.1597/06-218.1
  33. Mahabob MN, Anbuselvan GJ, Kumar BS, Raja S, Kothari S : Prevalence rate of supernumerary teeth among non-syndromic South Indian population: An analysis. J Pharm Bioallied Sci, 4(Suppl 2):S373-S375, 2012. https://doi.org/10.4103/0975-7406.100279
  34. Al-Kharboush GH, Al-Balkhi KM, Al-Moammar K : The prevalence of specific dental anomalies in a group of Saudi cleft lip and palate patients. Saudi Dent J, 27:75-80, 2015. https://doi.org/10.1016/j.sdentj.2014.11.007
  35. Tereza GPG, Carrara CF, Costa B : Tooth abnormalities of number and position in the permanent dentition of patients with complete bilateral cleft lip and palate. Cleft Palate Craniofac J, 47:247-252, 2010. https://doi.org/10.1597/08-268.1
  36. Lourenco Ribeiro L, Teixeira das Neves L, Costa B, Ribeiro Gomide M : Dental anomalies of the permanent lateral incisors and prevalence of hypodontia outside the cleft area in complete unilateral cleft lip and palate. Cleft Palate Craniofac J, 40:172-175, 2003. https://doi.org/10.1597/1545-1569_2003_040_0172_daotpl_2.0.co_2
  37. Papaefthymiou P, Agrafioti M, Yilmaz HN : Correlation of Dental Anomalies with Cleft Type and Gender in Non-Syndromic Oral Cleft Patients: A Cross-Sectional Study. Cleft Palate Craniofac J, 61:284-294, 2024. https://doi.org/10.1177/10556656221127536
  38. Demirjian A, Goldstein H, Tanner JM : A new system of dental age assessment. Hum Biol, 45:211-227, 1973.
  39. Rakhshan V : Congenitally missing teeth (hypodontia): A review of the literature concerning the etiology, prevalence, risk factors, patterns and treatment. Dent Res J, 12:1-13, 2015. https://doi.org/10.4103/1735-3327.150286
  40. Polder BJ, Van't Hof MA, Van der Linden FP, Kuijpers-Jagtman AM : A meta-analysis of the prevalence of dental agenesis of permanent teeth. Community Dent Oral Epidemiol, 32:217-226, 2004. https://doi.org/10.1111/j.1600-0528.2004.00158.x
  41. Suzuki A, Nakano M, Yoshizaki K, Yasunaga A, Haruyama N, Takahashi I : A longitudinal study of the presence of dental anomalies in the primary and permanent dentitions of cleft lip and/or palate patients. Cleft Palate Craniofac J, 54:309-320, 2017. https://doi.org/10.1597/15-186
  42. Konstantonis D, Alexandropoulos A, Konstantoni N, Nassika M : A cross-sectional analysis of the prevalence of tooth agenesis and structural dental anomalies in association with cleft type in non-syndromic oral cleft patients. Prog Orthod, 18:20, 2017.
  43. Mangione F, Nguyen L, Foumou N, Bocquet E, Dursun E : Cleft palate with/without cleft lip in French children: radiographic evaluation of prevalence, location and coexistence of dental anomalies inside and outside cleft region. Clin Oral Investig, 22:689-695, 2018. https://doi.org/10.1007/s00784-017-2141-z
  44. Rullo R, Festa VM, Rullo R, Addabbo F, Chiodini P, Vitale M, Perillo L : Prevalence of dental anomalies in children with cleft lip and unilateral and bilateral cleft lip and palate. Eur J Paediatr Dent, 16:229-232, 2015.