Acknowledgement
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2021R1G1A1092356).
References
- Harms M, Seale P. Brown and beige fat: development, function and therapeutic potential. Nat Med 2013; 19(10): 1252-1263. https://doi.org/10.1038/nm.3361
- Park J, Shin S, Liu L, Jahan I, Ong SG, Xu P, et al. Progenitor-like characteristics in a subgroup of UCP1+ cells within white adipose tissue. Dev Cell 2021; 56(7): 985-999.e4. https://doi.org/10.1016/j.devcel.2021.02.018
- Wu R, Park J, Qian Y, Shi Z, Hu R, Yuan Y, et al. Genetically prolonged beige fat in male mice confers long-lasting metabolic health. Nat Commun 2023; 14(1): 2731.
- Perez LM, Bernal A, de Lucas B, San Martin N, Mastrangelo A, Garcia A, et al. Altered metabolic and stemness capacity of adipose tissue-derived stem cells from obese mouse and human. PLoS One 2015; 10(4): e0123397.
- Shin S, El-Sabbagh AS, Lukas BE, Tanneberger SJ, Jiang Y. Adipose stem cells in obesity: challenges and opportunities. Biosci Rep 2020; 40(6): BSR20194076.
- Yuan Y, Shin S, Shi Z, Shu G, Jiang Y. Postnatal tamoxifen exposure induces long-lasting changes to adipose tissue in adult mice. Mol Biotechnol. Forthcoming 2023.
- Matsuo T, Takeuchi H, Suzuki H, Suzuki M. Body fat accumulation is greater in rats fed a beef tallow diet than in rats fed a safflower or soybean oil diet. Asia Pac J Clin Nutr 2002; 11(4): 302-308. https://doi.org/10.1046/j.1440-6047.2002.00299.x
- Takahashi Y, Ide T, Fujita H. Dietary gamma-linolenic acid in the form of borage oil causes less body fat accumulation accompanying an increase in uncoupling protein 1 mRNA level in brown adipose tissue. Comp Biochem Physiol B Biochem Mol Biol 2000; 127(2): 213-222. https://doi.org/10.1016/S0305-0491(00)00254-6
- Shin S, Ajuwon KM. Divergent response of murine and porcine adipocytes to stimulation of browning genes by 18-carbon polyunsaturated fatty acids and beta-receptor agonists. Lipids 2018; 53(1): 65-75. https://doi.org/10.1002/lipd.12010
- Shin S, Ajuwon KM. Effects of diets differing in composition of 18-c fatty acids on adipose tissue thermogenic gene expression in mice fed high-fat diets. Nutrients 2018; 10(2): 256.
- Massiera F, Saint-Marc P, Seydoux J, Murata T, Kobayashi T, Narumiya S, et al. Arachidonic acid and prostacyclin signaling promote adipose tissue development: a human health concern? J Lipid Res 2003; 44(2): 271-279. https://doi.org/10.1194/jlr.M200346-JLR200
- Shin S. Regulation of adipose tissue biology by long-chain fatty acids: metabolic effects and molecular mechanisms. J Obes Metab Syndr 2022; 31(2): 147-160. https://doi.org/10.7570/jomes22014
- Wijers SL, Saris WH, van Marken Lichtenbelt WD. Cold-induced adaptive thermogenesis in lean and obese. Obesity (Silver Spring) 2010; 18(6): 1092-1099. https://doi.org/10.1038/oby.2010.74
- Louwen F, Ritter A, Kreis NN, Yuan J. Insight into the development of obesity: functional alterations of adipose-derived mesenchymal stem cells. Obes Rev 2018; 19(7): 888-904. https://doi.org/10.1111/obr.12679
- Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 2007; 117(1): 175-184. https://doi.org/10.1172/JCI29881
- Lee YH, Petkova AP, Mottillo EP, Granneman JG. In vivo identification of bipotential adipocyte progenitors recruited by β3-adrenoceptor activation and high-fat feeding. Cell Metab 2012; 15(4): 480-491. https://doi.org/10.1016/j.cmet.2012.03.009
- Wu MV, Bikopoulos G, Hung S, Ceddia RB. Thermogenic capacity is antagonistically regulated in classical brown and white subcutaneous fat depots by high fat diet and endurance training in rats: impact on whole-body energy expenditure. J Biol Chem 2014; 289(49): 34129-34140. https://doi.org/10.1074/jbc.M114.591008
- Gregoire FM. Adipocyte differentiation: from fibroblast to endocrine cell. Exp Biol Med (Maywood) 2001; 226(11): 997-1002. https://doi.org/10.1177/153537020122601106
- Park S, Shin S, Lim Y, Shin JH, Seong JK, Han SN. Korean pine nut oil attenuated hepatic triacylglycerol accumulation in high-fat diet-induced obese mice. Nutrients 2016; 8(1): 59.
- Shin S, Ajuwon KM. Lipopolysaccharide alters thermogenic and inflammatory genes in white adipose tissue in mice fed diets with distinct 18-carbon fatty-acid composition. Lipids 2018; 53(9): 885-896. https://doi.org/10.1002/lipd.12101
- Xu X, Ying Z, Cai M, Xu Z, Li Y, Jiang SY, et al. Exercise ameliorates high-fat diet-induced metabolic and vascular dysfunction, and increases adipocyte progenitor cell population in brown adipose tissue. Am J Physiol Regul Integr Comp Physiol 2011; 300(5): R1115-R1125. https://doi.org/10.1152/ajpregu.00806.2010
- Carpene C, Galitzky J, Collon P, Esclapez F, Dauzats M, Lafontan M. Desensitization of beta-1 and beta-2, but not beta-3, adrenoceptor-mediated lipolytic responses of adipocytes after long-term norepinephrine infusion. J Pharmacol Exp Ther 1993; 265(1): 237-247.
- Rubio A, Raasmaja A, Silva JE. Thyroid hormone and norepinephrine signaling in brown adipose tissue. II: differential effects of thyroid hormone on beta 3-adrenergic receptors in brown and white adipose tissue. Endocrinology 1995; 136(8): 3277-3284. https://doi.org/10.1210/endo.136.8.7628361
- Bakopanos E, Silva JE. Thiazolidinediones inhibit the expression of beta3-adrenergic receptors at a transcriptional level. Diabetes 2000; 49(12): 2108-2115. https://doi.org/10.2337/diabetes.49.12.2108
- Seale P, Kajimura S, Spiegelman BM. Transcriptional control of brown adipocyte development and physiological function--of mice and men. Genes Dev 2009; 23(7): 788-797. https://doi.org/10.1101/gad.1779209
- Kajimura S, Seale P, Spiegelman BM. Transcriptional control of brown fat development. Cell Metab 2010; 11(4): 257-262. https://doi.org/10.1016/j.cmet.2010.03.005
- Wang B, Kong Q, Li X, Zhao J, Zhang H, Chen W, et al. A high-fat diet increases gut microbiota biodiversity and energy expenditure due to nutrient difference. Nutrients 2020; 12(10): 3197.
- Zhang G, Sun Q, Liu C. Influencing factors of thermogenic adipose tissue activity. Front Physiol 2016; 7: 29.
- Laiglesia LM, Lorente-Cebrian S, Prieto-Hontoria PL, Fernandez-Galilea M, Ribeiro SM, Sainz N, et al. Eicosapentaenoic acid promotes mitochondrial biogenesis and beige-like features in subcutaneous adipocytes from overweight subjects. J Nutr Biochem 2016; 37: 76-82. https://doi.org/10.1016/j.jnutbio.2016.07.019
- Zhao M, Chen X. Eicosapentaenoic acid promotes thermogenic and fatty acid storage capacity in mouse subcutaneous adipocytes. Biochem Biophys Res Commun 2014; 450(4): 1446-1451. https://doi.org/10.1016/j.bbrc.2014.07.010
- Kim J, Okla M, Erickson A, Carr T, Natarajan SK, Chung S. Eicosapentaenoic acid potentiates brown thermogenesis through FFAR4-dependent up-regulation of miR-30b and miR-378. J Biol Chem 2016; 291(39): 20551-20562. https://doi.org/10.1074/jbc.M116.721480
- Kim M, Goto T, Yu R, Uchida K, Tominaga M, Kano Y, et al. Fish oil intake induces UCP1 upregulation in brown and white adipose tissue via the sympathetic nervous system. Sci Rep 2015; 5(1): 18013.
- Hwang DH, Kim JA, Lee JY. Mechanisms for the activation of Toll-like receptor 2/4 by saturated fatty acids and inhibition by docosahexaenoic acid. Eur J Pharmacol 2016; 785: 24-35. https://doi.org/10.1016/j.ejphar.2016.04.024
- Calder PC. n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr 2006; 83(6 Suppl): 1505S-1519S. https://doi.org/10.1093/ajcn/83.6.1505S
- Sharma P, Agnihotri N. Fish oil and corn oil induced differential effect on beiging of visceral and subcutaneous white adipose tissue in high-fat-diet-induced obesity. J Nutr Biochem 2020; 84: 108458.
- Lim JH, Gerhart-Hines Z, Dominy JE, Lee Y, Kim S, Tabata M, et al. Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex. J Biol Chem 2013; 288(10): 7117-7126. https://doi.org/10.1074/jbc.M112.415729
- Shin S, Ajuwon KM. Effect of lipopolysaccharide on peripheral tissue and hypothalamic expression of metabolic and inflammatory markers in mice fed high-fat diets with distinct 18-carbon fatty acid composition. Lipids 2021; 56(5): 509-519. https://doi.org/10.1002/lipd.12318
- Rodriguez VM, Portillo MP, Pico C, Macarulla MT, Palou A. Olive oil feeding up-regulates uncoupling protein genes in rat brown adipose tissue and skeletal muscle. Am J Clin Nutr 2002; 75(2): 213-220. https://doi.org/10.1093/ajcn/75.2.213
- Jones PJ, Jew S, AbuMweis S. The effect of dietary oleic, linoleic, and linolenic acids on fat oxidation and energy expenditure in healthy men. Metabolism 2008; 57(9): 1198-1203. https://doi.org/10.1016/j.metabol.2008.04.012
- Maurer SF, Dieckmann S, Lund J, Fromme T, Hess AL, Colson C, et al. No effect of dietary fish oil supplementation on the recruitment of brown and brite adipocytes in mice or humans under thermoneutral conditions. Mol Nutr Food Res 2021; 65(2): e2000681.
- Keller H, Dreyer C, Medin J, Mahfoudi A, Ozato K, Wahli W. Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers. Proc Natl Acad Sci U S A 1993; 90(6): 2160-2164. https://doi.org/10.1073/pnas.90.6.2160
- Kliewer SA, Sundseth SS, Jones SA, Brown PJ, Wisely GB, Koble CS, et al. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma. Proc Natl Acad Sci U S A 1997; 94(9): 4318-4323. https://doi.org/10.1073/pnas.94.9.4318
- Kim KN, Yao Y, Ju SY. Short chain fatty acids and fecal microbiota abundance in humans with obesity: a systematic review and meta-analysis. Nutrients 2019; 11(10): 2512.
- Eslick S, Thompson C, Berthon B, Wood L. Short-chain fatty acids as anti-inflammatory agents in overweight and obesity: a systematic review and meta-analysis. Nutr Rev 2022; 80(4): 838-856. https://doi.org/10.1093/nutrit/nuab059