The Journal of the Korea institute of electronic communication sciences (한국전자통신학회논문지)

Korea Institute of Electronic Communication Science (한국전자통신학회)
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Differences between Species Based on Multiple Sequence Alignment Analysis

다중서열정렬에 기반한 종의 차이

  • 권혁주 (부경대학교 해양기상정보센터) ;
  • 김상진 (부경대학교 지구환경시스템과학부) ;
  • 김근무 (부경대학교 지구환경시스템과학부)
  • Received : 2024.02.29
  • Accepted : 2024.04.12
  • Published : 2024.04.30
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Abstract

Multiple sequence alignment (MSA) is a method of collecting and aligning multiple protein sequences or nucleic acid sequences that perform the same function in various organisms at once. clustalW, a representative multiple sequence alignment algorithm using BioPython, compares the degree of alignment by column position. In addition, a web logo and phylogenetic tree are created to visualize conserved sequences in order to improve understanding. An example was given to confirm the differences between humans and other species, and applications of BioPython are presented.

다중서열정렬(MSA : multiple sequence alignment)은 다양한 생명체에서 같은 기능을 하는 여러 개의 단백질 서열이나 핵산 서열을 한 번에 모아서 서로 정렬하는 방법이다. 바이오파이썬을 이용하여 인간이 다른 동물과 어떻게 다른지 조사하였다. 대표적인 다중서열정렬 알고리즘인 clustalW는 열의 위치별로 정렬된 정도를 비교한다. 또한, 웹로고와 계통수를 만들어서 보존서열을 가시화하여 이해도를 향상한다. 인간과 다른 동물의 차이점을 확인하는 예를 제시하고 바이오파이썬을 활용도를 제시한다.

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