International Journal of Industrial Entomology and Biomaterials

Korean Society of Sericultural Science (한국잠사학회)
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Biomedical Application of Silk Sericin: Recent Research Trend

  • Seong-Gon Kim (Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University) ;
  • Je-Yong Choi (Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, Korea Mouse Pheno-typing Center, School of Medicine, Kyungpook National University) ;
  • HaeYong Kweon (Industrial Insect and Sericulture Division, National Institute of Agricultural Sciences, RDA)
  • Received : 2023.11.17
  • Accepted : 2023.12.14
  • Published : 2024.03.31
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Abstract

Silk sericin, a natural protein from silkworm cocoons, is emerging as a multifunctional biomaterial in biomedicine, particularly in tissue engineering and wound healing. Recent studies have highlighted its biocompatibility, biodegradability, and potential for chemical modification, which allows it to be incorporated into various scaffold architectures. This review article synthesizes current research, including the development of sericin-based hydrogel scaffolds for tissue engineering and sericin's role in enhancing wound healing. Key findings demonstrate sericin's ability to refine scaffold porosity and mechanical strength, expedite tissue healing, and reduce bacterial load in wounds. The integration of sericin into novel bioactive dressings and its use in peripheral nerve injury repair are also discussed, showcasing its adaptability and efficacy. The convergence of these studies illustrates the broad applications of sericin, from scaffold design to clinical interventions, making it a promising material in regenerative medicine and tissue engineering, with the potential to improve patient outcomes significantly.

Keywords

Acknowledgement

This work was carried out the support of "Cooperative Research Program for Agriculture Science and Technology Development (Project No PJ015626032021)" Rural Development Administration, Republic of Korea.

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