Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Methylanthranilate, a Food Fragrance Attenuates Skin Pigmentation through Downregulation of Melanogenic Enzymes by cAMP Suppression

  • Heui-Jin Park (College of Pharmacy, Ewha Womans University) ;
  • Kyuri Kim (College of Pharmacy, Ewha Womans University) ;
  • Eun-Young Lee (Department of Chemistry and Nanoscience, Ewha Womans University) ;
  • Prima F. Hillman (Department of Chemistry and Nanoscience, Ewha Womans University) ;
  • Sang-Jip Nam (Department of Chemistry and Nanoscience, Ewha Womans University) ;
  • Kyung-Min Lim (College of Pharmacy, Ewha Womans University)
  • Received : 2023.05.30
  • Accepted : 2023.08.28
  • Published : 2024.03.01
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Abstract

Methyl anthranilate (MA) is a botanical fragrance used in food flavoring with unexplored potential in anti-pigment cosmetics. MA dose-dependently reduced melanin content without affecting cell viability, inhibited dendrite elongation and melanosome transfer in the co-culture system of human melanoma cells (MNT-1) and human keratinocyte cell line (HaCaT), and downregulated melanogenic genes, including tyrosinase, tyrosinase-related protein 1 and 2 (TRP-1, TRP-2). Additionally, MA decreased cyclic adenosine monophosphate (cAMP) production and exhibited a significant anti-pigmentary effect in MelanodermTM. These results suggest that MA is a promising anti-pigmentary agent for replacing or complementing existing anti-pigmentary cosmetics.

Keywords

Acknowledgement

This work was supported by grants from National Research Foundation of Korea (Grant No. 2021R1A2C2013347, 2021R1A6C101A442 and MSIT 2018R1A5A2025286).

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