Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Inhaled Volatile Molecules-Responsive TRP Channels as Non-Olfactory Receptors

  • Hyungsup Kim (Brain Science Institute, Korea Institute of Science and Technology (KIST)) ;
  • Minwoo Kim (Department of Medical and Digital Engineering, College of Engineering, Hanyang University) ;
  • Yongwoo Jang (Department of Medical and Digital Engineering, College of Engineering, Hanyang University)
  • Received : 2023.06.20
  • Accepted : 2023.07.12
  • Published : 2024.03.01
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Abstract

Generally, odorant molecules are detected by olfactory receptors, which are specialized chemoreceptors expressed in olfactory neurons. Besides odorant molecules, certain volatile molecules can be inhaled through the respiratory tract, often leading to pathophysiological changes in the body. These inhaled molecules mediate cellular signaling through the activation of the Ca2+-permeable transient receptor potential (TRP) channels in peripheral tissues. This review provides a comprehensive overview of TRP channels that are involved in the detection and response to volatile molecules, including hazardous substances, anesthetics, plant-derived compounds, and pheromones. The review aims to shed light on the biological mechanisms underlying the sensing of inhaled volatile molecules. Therefore, this review will contribute to a better understanding of the roles of TRP channels in the response to inhaled molecules, providing insights into their implications for human health and disease.

Keywords

Acknowledgement

This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI22C1973000022).

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