Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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AMPK Alchemy: Therapeutic Potentials in Allergy, Aging, and Cancer

  • Ram Hari Pokhrel (College of Pharmacy, Yeungnam University) ;
  • Suman Acharya (College of Pharmacy, Yeungnam University) ;
  • Sunil Mishra (College of Pharmacy, Yeungnam University) ;
  • Ye Gu (College of Pharmacy, Yeungnam University) ;
  • Umar Manzoor (Interdisciplinary Graduate Program in Advanced Convergence Technology and Science, Jeju National University) ;
  • Jeon-Kyung Kim (School of Pharmacy and Institute of New Drug Development, Jeonbuk National University) ;
  • Youngjun Park (Interdisciplinary Graduate Program in Advanced Convergence Technology and Science, Jeju National University) ;
  • Jae-Hoon Chang (College of Pharmacy, Yeungnam University)
  • Received : 2023.12.18
  • Accepted : 2024.01.18
  • Published : 2024.03.01
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Abstract

All cells are equipped with intricate signaling networks to meet the energy demands and respond to the nutrient availability in the body. AMP-activated protein kinase (AMPK) is among the most potent regulators of cellular energy balance. Under ATP -deprived conditions, AMPK phosphorylates substrates and affects various biological processes, such as lipid/glucose metabolism and protein synthesis. These actions further affect the cell growth, death, and functions, altering the cellular outcomes in energy-restricted environments. AMPK plays vital roles in maintaining good health. AMPK dysfunction is observed in various chronic diseases, making it a promising target for preventing and alleviating such diseases. Herein, we highlight the different AMPK functions, especially in allergy, aging, and cancer, to facilitate the development of new therapeutic approaches in the future.

Keywords

Acknowledgement

This study was supported by the Yeungnam University Research Grant (grant number 223A380004).

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