The korean journal of orthodontics (대한치과교정학회지)

The Korean Association Of Orthodontists (대한치과교정학회)
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Role of vitamin D for orthodontic tooth movement, external apical root resorption, and bone biomarker expression and remodeling: A systematic review

  • Martina Ferrillo (Dentistry Unit, Department of Health Sciences, Magna Graecia University of Catanzaro) ;
  • Dario Calafiore (Physical Medicine and Rehabilitation Unit, Department of Neurosciences, ASST Carlo Poma) ;
  • Lorenzo Lippi (Physical and Rehabilitative Medicine, Department of Health Sciences, University of Eastern Piedmont ) ;
  • Francesco Agostini (Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Sapienza University) ;
  • Mario Migliario (Dentistry Unit, Department of Translational Medicine, University of Eastern Piedmont ) ;
  • Marco Invernizzi (Physical and Rehabilitative Medicine, Department of Health Sciences, University of Eastern Piedmont ) ;
  • Amerigo Giudice (Dentistry Unit, Department of Health Sciences, Magna Graecia University of Catanzaro) ;
  • Alessandro de Sire (Physical Medicine and Rehabilitation Unit, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro)
  • Received : 2023.04.10
  • Accepted : 2023.09.18
  • Published : 2024.01.25
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Abstract

Objective: This systematic review aimed to evaluate the correlation between vitamin D levels and the rate of tooth movement, external apical root resorption, bone biomarker expression, and bone remodeling. Methods: Three databases (PubMed, Scopus, and Web of Science) were systematically searched from inception until 14th March 2023 to identify studies investigating the correlation between orthodontic tooth movement and vitamin D in animals and humans. The quality assessment was made in accordance with the Joanna Briggs Institute Critical Appraisal Checklist. Results: Overall, 519 records were identified, and 19 were selected for the qualitative synthesis. Eleven studies investigated the effect of local administration (injections in the periodontal ligament, to the gingiva distal to the teeth, or submucosae palatal area) and systemic administration (oral supplementation) of vitamin D on tooth movement, external apical root movement, pro-inflammatory cytokines, and bone remodeling factors. The remaining eight studies investigated the correlation between serum vitamin D levels and salivary vitamin D levels on bone turnover markers and tooth movement. Conclusions: The findings of this systematic review support that vitamin D3 local injections might increase the rate of tooth movement via the receptor activator of the nuclear factor-kB/osteoprotegerin axis. However, the non-uniform study designs and the different protocols and outcome methods make it challenging to draw reliable conclusions.

Keywords

References

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