Journal of the Korean Applied Science and Technology (한국응용과학기술학회지)

The Korean Society of Applied Science and Technology (한국응용과학기술학회)
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A Study on the Expression of Genes Related to Extracellular Substrates of Flavonoids

플라보노이드의 세포외 기질 관련 유전자 발현에 관한 연구

  • Jae-Eun Lee (Department of Beauty cosmetics, Osan Unversity) ;
  • Seyeon Park (Department of Applied chemistry and Cosmetics, Dongduk Women's University)
  • 이재은 (오산대학교 뷰티코스메틱계열) ;
  • 박세연 (동덕여자대학교 자연정보대학 응용화학전공)
  • Received : 2023.07.24
  • Accepted : 2023.10.25
  • Published : 2023.10.31
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Abstract

In this study, we would like to confirm the collagen recovery effect through cell experiments of the flavonoid apigenin and baicalein and propose results that can support the collagen recovery effect through comparative transcriptome analysis. As a result of the study, it was confirmed that apigenin and baicalein were effective in recovering type I collagen damaged by UV in the HS68 cell line, and that both substances resulted in changes in the expression of ECM-related genes. Not only did it show a common mechanism for regulating the ECM, but it also showed the results of changing different categories of genes, making it possible to predict that it would have various effects on cells.

본 연구에서는 flavonoid apigenin과 baicalein의 세포 실험으로 콜라겐 회복효과를 확인하고 전사체 비교 분석을 통하여 collagen 회복 효과를 뒷받침할 수 있는 결과를 제안하고자 한다. 연구 결과 apigenin과 baicalein은 HS68 세포주에서 UV에 의해 손상된 I형 collagen 회복에 효과를 보였으며, 두 물질 모두에서 ECM 관련 유전자들의 발현 변화를 확인하였다. ECM을 조절하는 공통적인 메커니즘을 보일 뿐 아니라 각각 다른 범주의 유전자들을 변화시키는 결과도 보여서, 세포에 다양한 영향을 미치는 것으로 예측할 수 있었다.

Keywords

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