Nuclear Engineering and Technology

Korean Nuclear Society (한국원자력학회)
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Radioactivity of biological samples of patients treated with 90Y-DOTATOC

  • Marija Z. Jeremic (University Clinical Center Kragujevac, Department of Nuclear Medicine) ;
  • Milovan D. Matovic (University Clinical Center Kragujevac, Department of Nuclear Medicine) ;
  • Nenad R. Mijatovic (University Clinical Center Kragujevac, Department of Nuclear Medicine) ;
  • Suzana B. Pantovic (University of Kragujevac, Faculty of Medical Sciences, Department of Physiology) ;
  • Dragana Z. Krstic (University of Kragujevac, Faculty of Science, Department of Physics) ;
  • Tatjana B. Miladinovic (University of Kragujevac, Institute for Information Technologies, Department of Sciences) ;
  • Dragoslav R. Nikezic (State University of Novi Pazar)
  • Received : 2022.07.20
  • Accepted : 2023.06.26
  • Published : 2023.10.25
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Abstract

Dosimetric studies in Nuclear Medicine are very important, especially with new therapeutic methods, the number of which has increased significantly with the Theranostic approach (determining diagnostic-therapeutic pairs where similar molecules are labelled with different isotopes in order to diagnose and treat malignant diseases). Peptide receptor radionuclide therapy (PRRT) has been used successfully for many years to treat neuroendocrine tumors (NET). 90Y-DOTATOC is one of the radiopharmaceuticals used frequently in this type of therapy. In this work, blood and urine samples from 13 patients treated with 90Y-DOTATOC were measured by a liquid scintillation beta counter (LSC). Calibration of the beta counter for this type of measurement was done and all results are presented in the paper. The presented paper also provides a methodology for determining the measurement uncertainty for this type of measurement. Immediately after the administration of radiopharmaceuticals, the activity in the blood was different from 6.31% to 88.9% of the applied radioactivity, while 3 h after the termination of the application, the average value of radiopharmaceuticals in the blood was only 3.84%. The activity in the excreted urine depended on the time when the patients urinated after the therapy. It was measured that as much as 58% of the applied radioactivity was excreted in the first urine after the therapy in a patient who urinated 4.5 h after the completed application of the therapy. In most patients, the highest urine activity was in the first 10 h after the application, while the activities after that time were negligibly low. The described methodology of measuring and evaluating activity in blood and excreted urine can be applied to other radiopharmaceuticals used in nuclear medicine. It could be useful for researchers for dosimetric assessments in clinical application of PRRT.

Keywords

Acknowledgement

The authors acknowledge funding provided by the Ministry of Education, Science and Technological Development of the Republic of Serbia Grant No III41007 and Ministry of Science, Technological Development and Innovation of the Republic of Serbia Grants No 451-03-47/2023-01/200122 and 451-03-47/2023-01/200378

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