Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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A Study on Anti-inflammatory and Skin Soothing Cosmetics Material of COMPAREX

COMPAREX 의 항염 및 진정 화장품 소재로서의 연구

  • Ha Yeon Kim (Life Science R&D Center, HYUNDAI BIOLAND Co., Ltd.) ;
  • Jae Seok Lee (Life Science R&D Center, HYUNDAI BIOLAND Co., Ltd.) ;
  • So Hun Lee (Life Science R&D Center, HYUNDAI BIOLAND Co., Ltd.) ;
  • Ye Hyang Kim (Life Science R&D Center, HYUNDAI BIOLAND Co., Ltd.) ;
  • Eun Young Jeong (Life Science R&D Center, HYUNDAI BIOLAND Co., Ltd.) ;
  • Kang Hyuk Lee (Life Science R&D Center, HYUNDAI BIOLAND Co., Ltd.) ;
  • Song Seok Shin (Life Science R&D Center, HYUNDAI BIOLAND Co., Ltd.)
  • 김하연 (현대바이오랜드 생명과학연구소) ;
  • 이재석 (현대바이오랜드 생명과학연구소) ;
  • 이소헌 (현대바이오랜드 생명과학연구소) ;
  • 김예향 (현대바이오랜드 생명과학연구소) ;
  • 정은영 (현대바이오랜드 생명과학연구소) ;
  • 이강혁 (현대바이오랜드 생명과학연구소) ;
  • 신송석 (현대바이오랜드 생명과학연구소)
  • Received : 2023.08.04
  • Accepted : 2023.09.22
  • Published : 2023.09.30
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Abstract

Recently, there has been a growing interest in the development of safer and more effective soothing materials to calm skin that has become sensitive to various external factors. The aim of this study was to investigate the skin soothing and anti-inflammatory effects of COMPAREX compared to Portulaca Oleracea extract. The results showed that COMPAREX significantly inhibited LPS-induced NO production and the expression of inflammatory factors iNOS, COX-2, TNF-α, and IL-6 more than P. oleracea extract. In addition, COMPAREX has been confirmed to have a more effective sedative effect by further inhibiting the gene and protein expression of IL-1α against SDS stimulation than the Portulaca Oleracea extract. Furthermore, COMPAREX inhibited the expression of inflammatory factors COX-2 and IL-8 increased by PM2.5 and suppressed H2O2-mediated carbonylated protein in hair cell. These results suggest that COMPAREX has shown the potential to be used as an improved natural soothing material over P. oleracea extract, and it is expected to be used as a derma cosmetic material in the future.

최근 다양한 외부 요인에 의해 민감해진 피부를 진정시키기 위해 더욱 안전하고 효과적인 진정 소재 개발에 대한 관심이 증가하고 있다. 따라서 본 연구에서는 항염 효능으로 잘 알려진 마치현 추출물을 기반으로 애엽, 홍경천 추출물을 혼합함으로써 COMPAREX를 제조하고, 피부 진정 효능에 미치는 영향을 마치현 단일 추출물과 비교하였다. 실험 결과, COMPAREX는 마치현 추출물 보다 LPS에 의해 유도된 NO 생성을 더욱 억제시키고, 염증성 인자인 iNOS, COX-2, TNF-α, IL-6의 발현을 현저히 억제시킴으로써 염증완화 효능이 더 효과적인 것을 확인하였다. 또한, COMPAREX는 마치현 추출물 보다 SDS 자극에 대해 IL-1α의 유전자 및 단백질 발현을 더욱 억제시킴으로써 진정 효능이 더 효과적인 것을 확인하였다. 추가적으로, 모발세포에서 COMPAREX는 PM2.5에 의해 증가된 COX-2, IL-8의 발현을 억제시켜 두피 염증 완화 효능이 있으며, carbonylated protein을 저해시킴으로써 외부 자극으로부터 손상된 두피를 보호할 수 있는 효능을 확인하였다. 따라서, COMPAREX는 마치현 단일 추출물 보다 개선된 천연 진정 소재로의 활용 가능성을 보였고, 향후 더마 코스메틱 소재로 활용될 수 있을 것으로 기대된다.

Keywords

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