The Korean Journal of Pain

  • 제36권4호
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  • Pages.425-440
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  • 2023
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  • 2005-9159(pISSN)
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  • 2093-0569(eISSN)
대한통증학회 (The Korean Pain Society)
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Muscimol as a treatment for nerve injury-related neuropathic pain: a systematic review and meta-analysis of preclinical studies

  • Hamzah Adel Ramawad (Department of Emergency Medicine, NYC Health + Hospitals) ;
  • Parsa Paridari (Physiology Research Center, Iran University of Medical Sciences) ;
  • Sajjad Jabermoradi (Physiology Research Center, Iran University of Medical Sciences) ;
  • Pantea Gharin (Physiology Research Center, Iran University of Medical Sciences) ;
  • Amirmohammad Toloui (Physiology Research Center, Iran University of Medical Sciences) ;
  • Saeed Safari (Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences) ;
  • Mahmoud Yousefifard (Physiology Research Center, Iran University of Medical Sciences)
  • 투고 : 2023.06.02
  • 심사 : 2023.08.01
  • 발행 : 2023.10.01
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초록

Background: Muscimol's quick onset and GABAergic properties make it a promising candidate for the treatment of pain. This systematic review and meta-analysis of preclinical studies aimed at summarizing the evidence regarding the efficacy of muscimol administration in the amelioration of nerve injury-related neuropathic pain. Methods: Two independent researchers performed the screening process in Medline, Embase, Scopus and Web of Science extracting data were extracted into a checklist designed according to the PRISMA guideline. A standardized mean difference (SMD [95% confidence interval]) was calculated for each. To assess the heterogeneity between studies, 2 and chi-square tests were utilized. In the case of heterogeneity, meta-regression and subgroup analyses were performed to identify the potential source. Results: Twenty-two articles met the inclusion criteria. Pooled data analysis showed that the administration of muscimol during the peak effect causes a significant reduction in mechanical allodynia (SMD = 1.78 [1.45-2.11]; P < 0.0001; I2 = 72.70%), mechanical hyperalgesia (SMD = 1.62 [1.28-1.96]; P < 0.0001; I2 = 40.66%), and thermal hyperalgesia (SMD = 2.59 [1.79-3.39]; P < 0.0001; I2 = 80.33%). This significant amendment of pain was observed at a declining rate from 15 minutes to at least 180 minutes post-treatment in mechanical allodynia and mechanical hyperalgesia, and up to 30 minutes in thermal hyperalgesia (P < 0 .0001). Conclusions: Muscimol is effective in the amelioration of mechanical allodynia, mechanical hyperalgesia, and thermal hyperalgesia, exerting its analgesic effects 15 minutes after administration for up to at least 3 hours.

키워드

과제정보

This study was supported by the Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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