The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
권호 표지
DOI QR코드

DOI QR Code

Research on vasorelaxant effects of 20 Korean native plants

국내 자생식물 20종의 혈관이완 효능에 대한 실험연구

  • Bumjung Kim (Department of Korean Medicine and Healthcare, Kyung Hee Cyber University)
  • 김범정 (경희사이버대학교 한방건강관리학과)
  • Received : 2023.08.10
  • Accepted : 2023.09.25
  • Published : 2023.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : The objective of present study was to investigate the vasorelaxant effects of 20 Korean native plants on isolated rat thoracic aorta precontracted with phenylephrine (PE). Methods : Dried 20 plant materials were extracted 3 times with water, ethanol, or methanol for 3h in the reflux apparatus at 70 ± 5℃. Male SD rats were anesthetized by ether inhalation, and their aorta rings were isolated and placed in 10 ㎖ Krebs Henseleit (KH) buffer. While using an isolated organ-chamber technique, the aorta rings were maintained by bubbling with a gas mixture of 95% O2-5% CO2 at 37℃. Changes in isometric tension of aorta rings were recorded via isometric transducers connected to a Powerlab Data Acquisition System. Results : Among the 20 native plants, Chrysanthemum indicum L. flower, Nelumbo nucifera Gaertn. rhizome, Schisandra chinensis (Turcz.) Baill. fruit, Anthriscus sylvestris (L.) Hoffm. root, Corydalis turtschaninovii Besser tuber, Corydalis decumbens (Thunb.) Pers. tuber, and Dolichos lablab L. seed showed significant vasorelaxant effect on the contraction of aorta rings induced by PE. In contrast, Mertensia maritima subsp. asiatica Takeda whole plant, Ajuga decumbens Thunb. whole plant, Trigonotis peduncularis (Trevis.) Benth. ex Baker & S.Moore whole plant, Dioscorea quinquelobate Thunb. rhizome, Allium microdictyon Prokh aerial part, Momordica charantia L. fruit, Carthamus tinctorius L. flower, and Clematis terniflora DC. root constricted more the aorta rings precontracted by PE Conclusion : These results suggest that the possibility as useful herbal resources for the development of functional foods or medicines for hypertension treatment.

Keywords

Acknowledgement

이 연구는 2021년도 경희사이버대학교 연구비지원에 의한 결과임. (KHCU 2021-5)

References

  1. Gwak M. Development of a Self-Management Adherence Instrument for Patients with Hypertension. Journal of Korean Academic Society of Home Health Care Nursing. 2023;30(1):37-47. DOI: 10.22705/jkashcn.2023.30.1.37
  2. Lee W. Understanding Hypertension. The Korean Institute of Electrical Engineers. 2017;66(12):50-2. https://www.dbpia.co.kr/Journal/articleDetail?nodeId=NODE07273119
  3. Kim S, Won J, Lee I. A Review of Recent Acupuncture Treatment for Hypertension - PubMed and Domestic Studies. The Journal of Internal Korean Medicine. 2020;41(1):29-43. DOI: 10.22246/JIKM.2020.41.1.29
  4. Ahn KT, Jin S-A, Jeong J-O. Diagnosis and Treatment of Hypertension: Based on the Guidelines of the Korean Society of Hypertension. Journal of the Korean Neurological Association. 2019;37(2):123-34. DOI: 10.17340/JKNA.2019.2.2
  5. Cho Y-H. Non-pharmacological treatment of hypertension. The Korean Association of Internal Medicine. 2019;129-33. https://www.ekjm.org/upload/42856647.pdf
  6. Sen T, Samanta SK. Medicinal plants, human health and biodiversity: a broad review. Adv Biochem Eng Biotechnol. 2015;147:59-110. DOI: 10.1007/10_2014_273
  7. Ajebli M, Eddouks M. Phytotherapy of Hypertension: An Updated Overview. Endocr Metab Immune Disord Drug Targets. 2020;20(6):812-39. DOI: 10.2174/1871530320666191227104648
  8. Lee J. Effects of oral health behavior on remaining teeth in Korean adults older than 45 years with hypertension and diabetes. Journal of Korean Society of Dental Hygiene. 2020;20(1):41-51. DOI: 10.13065/jksdh.20200005
  9. Zhao Q, Matsumoto K, Okada H, Ichiki H, Sakakibara I. Anti-hypertensive and anti-stroke effects of Chrysanthemum extracts in stroke-prone spontaneously hypertensive rats. Journal of Traditional Medicines. 2008;25(5+6):143-51. DOI: 10.11339/JTM.25.143
  10. Kang DG, Hur TY, Lee GM, Oh H, Kwon TO, Sohn EJ, Lee HS. Effects of Cudrania tricuspidata water extract on blood pressure and renal functions in NO-dependent hypertension. Life Sci. 2002;70(22): 2599-609. DOI: 10.1016/S0024-3205(02)01547-3
  11. Choo H, Lee S, Kim J, Jeong J. Effect of Clerodendron trichotomum Thunberg tea on antihypertension. The Korea Journal of Herbology. 2015;30(4):129-35. UCI: G704-000845.2015.30.4.005 G704-000845.2015.30.4.005
  12. Kang Y, Choi G, Jin W, Kim H, Kim D. Characterization of Morphological and Analytical Keys in Dioscoreae Nipponicae Rhizoma (Dioscorea nipponica Makino) and Dioscoreae Quinquelobatae Rhizoma (Dioscorea quinquelobata Thunb.) as Korean Herbal Medicines. Korean Herbal Medicine Informatics. 2014;2(1):7-14. DOI: 10.22674/KHMI2-1-2
  13. Han C, Qi J, Gao S, Li C, Ma Y, Wang J, Bai Y, Zheng X. Vasodilation effect of volatile oil from Allium macrostemon Bunge are mediated by PKA/NO pathway and its constituent dimethyl disulfide in isolated rat pulmonary arterials. Fitoterapia. 2017; 120:52-7. DOI: 10.1016/J.FITOTE.2017.05.007
  14. Zhang X, Pan Z, Wang Y, Liu P, Hu K. Taraxacum officinale-derived exosome-like nanovesicles modulate gut metabolites to prevent intermittent hypoxia-induced hypertension. Biomed Pharmacother. 2023;161. DOI: 10.1016/J.BIOPHA.2023.114572
  15. Zeng L, Chen M, Ahmad H, Zheng X, Ouyang Y, Yang P, Yang Z, Gao D, Tian Z. Momordica charantia Extract Confers Protection Against Hypertension in Dahl Salt-Sensitive Rats. Plant Foods Hum Nutr. 2022;77(3):373-82. DOI: 10.1007/S11130-022-00971-6
  16. Park S-H, Ham T-S, Han J-H. Effects of Ethanol - Extract of Lotus Root on the Renal Function and Blood Pressure of Fructose - Induced Hypertensive Rats. Journal of the East Asian Society of Dietary Life. 2005;15(2):165-70. UCI: G704-001333.2005.15.2.006 G704
  17. Ye BH, Lee SJ, Choi YW, Park SY, Kim CD. Preventive effect of gomisin J from Schisandra chinensis on angiotensin II-induced hypertension via an increased nitric oxide bioavailability. Hypertens Res. 2015;38(3):169-77. DOI: 10.1038/HR.2014.162
  18. Maneesai P, Prasarttong P, Bunbupha S, Kukongviriyapan U, Kukongviriyapan V, Tangsucharit P, Prachaney P, Pakdeechote P. Synergistic Antihypertensive Effect of Carthamus tinctorius L. Extract and Captopril in L-NAMEInduced Hypertensive Rats via Restoration of eNOS and AT 1R Expression. Nutrients. 2016;8(3). DOI: 10.3390/NU8030122