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Change of Growth Indicators by the Treatment of Korean Medicine

한의 성장 치료에 따른 성장 지표 변화

  • Oh Hye In (Department of Pediatrics, College of Korean Medicine, Daejeon University) ;
  • Lee Hyun Hee (Department of Pediatrics, College of Korean Medicine, Daejeon University) ;
  • Jeong Ji Eun (Department of Pediatrics, College of Korean Medicine, Daejeon University) ;
  • Lee Hye Lim (Department of Pediatrics, College of Korean Medicine, Daejeon University)
  • 오혜인 (대전대학교 한의과대학 한방소아과학교실) ;
  • 이현희 (대전대학교 한의과대학 한방소아과학교실) ;
  • 정지은 (대전대학교 한의과대학 한방소아과학교실) ;
  • 이혜림 (대전대학교 한의과대학 한방소아과학교실)
  • Received : 2023.07.10
  • Accepted : 2023.08.23
  • Published : 2023.08.31

Abstract

Objectives We aimed to analyze changes in growth indicators before and after Korean medicine treatment in patients treated at the pediatric department of a hospital. Methods We analyzed the medical records of children and adolescents under 18 years of age who underwent growth assessment between January 1, 2017 and December 31, 2022. Results A total of 21 patients were selected for this study. After treatment, there was a significant increase in the height percentile, whereas bone age-chronological age (BA-CA) and predicted adult height (PAH) did not show significant changes. No major adverse reactions were observed during the treatment. Growth reassessment was conducted twice for 10 participants. When comparing the growth indicators between the assessment sessions, the height percentile showed an increasing trend between the initial and the first growth reassessment. However, there were no significant differences between BA-CA and PAH across the different assessment periods. Conclusions There is a need to establish evidence for the efficacy and safety of continuous Korean medicine growth treatment through the long-term observation of growth indicators in patients undergoing treatment for two or more periods, as well as observational studies on liver and renal function indicators.

Keywords

References

  1. Health Insurance Review & Assessment Service. Statistics by ATC Codes (by In/Outpatient) [Internet]. Healthcare Bigdata Hub; 2015 [Updated 2021; cited 2023 Feb 8]. Available from: https://opendata.hira.or.kr/op/opc/olap4thDsInfoTab3.do?moveFlag=Y 
  2. Ministry of Health and Welfare. Korean medicine utilization survey [Internet]. National Institute of Korean Medicine Development; 2018 [Updated 2023; cited Apr 19]. Available from: https://www.mohw.go.kr/react/al/sal0301vw.jsp?PAR_MENU_ID=04&MENU_ID=0403&page=1&CONT_SEQ=375634. 
  3. Ministry of Health and Welfare. Korean medicine utilization survey [Internet]. National Institute of Korean Medicine Development; 2018 [Updated 2021; cited 2023 Feb 8]. Available from: https://www.mohw.go.kr/react/al/sal0301vw.jsp?PAR_MENU_ID=04&MENU_ID=0403&page=1&CONT_SEQ=365877&SEARCHKEY=TITLE&SEARCHVALUE=%ED%95%9C%EB%B0%A9 
  4. Lee HH, Shim SB, Lee HL. A survey on public perception of Korean medicine treatment for the development of Korean medicine clinical practice guideline and critical pathway for growth disorders. J Pediatr Korean Med. 2022;36(1):65-77. 
  5. Jung HH and Shim KS. The influences of herbal medicine as a growth-promoting complimentary therapy on predicted adult heights of children. Ann Pediatr Endocrinol Metab. 2008;13(2):172-6. 
  6. Kim SY, Oh YJ, Shin JY, Rhie YJ, Lee KH. Comparison of the Greulich-Pyle an Tanner Whitehouse (TW3) methods in bone age assessment. J Korean Soc Pediatr Endocrinol. 2008;13(1):50-5. 
  7. Kim HJ, Lee HJ, Park EJ. A clinical study on the effect of oriental medical treatment to the growth of children using bone age as measurer. J Pediatr Korean Med. 2006;20(3):23-32. 
  8. Jeong MJ, Gok SY, Lee SY. Pilot study of effect to the growth after the administration of herbal medicine to the prepuberty children. J Pediatr Korean Med. 2008;22(3):25-34. 
  9. Kim YJ, Lee SH, Jang SB, Lee JY, Chang GT, Lee BR. Intergrative traditional Korean medicine treatment for children with idiopathic short stature: A STROBE-compliant case series. Medicine. 2022;101(28):e29754. 
  10. Kang MJ, Kim EY, Shim YS, Jeong HR, Lee HJ, Yang S, Hwang IT. Factors affecting bone age maturation during 3 years of growth hormone treatment in patients with idiopathic growth hormone deficiency and idiopathic short stature; analysis of date from the LG growth study. Medicine. 2019;98(14):e14962. 
  11. Korean Disease Control and Prevention Agency. 2017 Growth chart for children and youth [Internet]. Korean National Heath & Nutrition Examination Survey; 2017 [Updated 2017; cited 2023 Apr 19]. Available from: https://knhanes.kdca.go.kr/knhanes/sub08/sub08_02.do 
  12. Yoon HJ, Lee YJ, Baek JH. A clinical study on growth of children based on analyzing body compositions and measuring bone age. J Pediatr Korean Med. 2009;23(2):131-44. 
  13. Kim SM. The characteristic of short stature children with improved PAH by Korean herbal medicine treatment [Master]. [Seoul]: Kyunghee University; 2020. 25p. 
  14. Tanner JM, Healy MJR, Goldstein H, Cameron N. Assessment of skeletal maturity and prediction of adults height (TW3 Method), 3/e. London: WB Saundres Ltd. 2001:1-128. 
  15. Kang KY, Han JK, Kim YH. The study on correlation-ship between parents' height and adult height prediction according to TW3 Method. J Pediatr Korean Med. 2012;26(3):46-54.  https://doi.org/10.7778/jpkm.2012.26.3.046
  16. Department of Pediatrics, Nationwide Korean Medicine College, Pediatrics of Korean medicine. 3rd ed. Seoul:Ui Sung Dang Publishing Co. 2022:29-30. 990-994. 
  17. Lee HL, Han JK, Kim YH. A study on comparison between growth indices of weak children groups via analyzing bone age and body composition. J Pediatr Korean Med. 2014;28(2):1-22.  https://doi.org/10.7778/jpkm.2014.28.2.001
  18. Park GM, Park JH, Jung JW, Han HW, Kim JY, Lee E, Cho HJ, Kim YH, Yoon JS, Yu JH, Kim TB, Hong SJ. Pediatric adverse drug reactions collected by an electronic reporting system in a single tertiary university hospital. Allergy Asthma Respir Dis. 2016;4(5):354-9.  https://doi.org/10.4168/aard.2016.4.5.354
  19. Park SC, Trinh TA, Lee WY, Baek JY, Lee SY, Choi KH, Ha JW, Kim CE, Kang KS, Lee HL. Effect of estrogen inhibition formula herbal mixture for danazol-induced precocious puberty in female rats: an experimental study with network pharmacology. IMR. 2021;10(3):100708. 
  20. Choi SH, Park EJ. A clinical study of the pediatric patients who visited oriental medical hospital for growth treatment J Pediatr Korean Med. 2018;32(4):51-62 
  21. Choi MH, Kim DG, Lee JY. Effect of genetic and environmental factors on growth. J Pediatr Korean Med. 2010;24(3):138-49. 
  22. Yu HY, Kim KB, Min SH, Kim KB. Effects to the growth after administration of Seongjangbojunggeonatang. J Pediatr Korean Med. 2009;23(2):103-15. 
  23. Lee HL, Yoo HS, Park SC. A case report of idiopathic precocious puberty in two children. J Pediatr Korean Med. 2017;31(1):74-81.  https://doi.org/10.7778/jpkm.2017.31.1.074
  24. The association of Korean Oriental Pediatrics. Childhood and adolescent growth disorder clinical practice guideline of Korean medicine. Gyeongsan: NIKOM. 2022:22-3. 
  25. Han JE, An TEB, Park JK, Sung HK, Yeon JH, Sung SH. Treatments of Korean Medicine for pediatric growth: a literature review of clinical studies. J Pediatr Korean Med. 2021;35(1):18-29. 
  26. Kong JC, Lee JH, Ko YS, Lee EG, Na C, Park DS, Song YS, Sing BC. The clinical observation on the growth of children treated with Korean herbal medicine, diet and exercise guidance. J Korean Med Rehabil. 2008;18(3):133-45. 
  27. Lee YJ, Baek JH, Ko MJ, Seo JM. Herbal medicine promotes growth of children. J Pediatr Korean Med. 2011;25(1):49-62.  https://doi.org/10.7778/jpkm.2011.25.1.049
  28. Kim JE, Baek JH. Effects of herbal medicine for growth of children: a retrospective study. J Pediatr Korean Med. 2016;30(4):87-98.  https://doi.org/10.7778/jpkm.2016.30.4.087
  29. Kim SS, Wi SD, Lee JH, Park HY, Cho SY, Han SW, Park HJ, Kim DW. The correlation of GH and IGF-I with the index of obesity and the change by exercise. Journal of Sport and Leisure Studies. 2001;16:271-80. 
  30. Lee SY, Cheong JO, Yang TK, Koo BH. The feasibility and safety of herbal medication on short stature. Korean J Orient Int Med. 2001;22(4):513-7.