Acknowledgement
Medical writing services were provided by Drs. Emma Pilling and Marielle Romet (Sante Active Edition). We would also like to thank the study participants and participating physicians for collecting the study data, and the Danone Nutricia Research team for their scientific input and critical review of the manuscript.
References
- Vandenplas Y, Abkari A, Bellaiche M, Benninga M, Chouraqui JP, Cokura F, et al. Prevalence and health outcomes of functional gastrointestinal symptoms in infants from birth to 12 months of age. J Pediatr Gastroenterol Nutr 2015;61:531-7. https://doi.org/10.1097/MPG.0000000000000949
- Iacono G, Merolla R, D'Amico D, Bonci E, Cavataio F, Di Prima L, et al. Gastrointestinal symptoms in infancy: a population-based prospective study. Dig Liver Dis 2005;37:432-8. https://doi.org/10.1016/j.dld.2005.01.009
- Bellaiche M, Oozeer R, Gerardi-Temporel G, Faure C, Vandenplas Y. Multiple functional gastrointestinal disorders are frequent in formula-fed infants and decrease their quality of life. Acta Paediatr 2018;107:1276-82. https://doi.org/10.1111/apa.14348
- Vandenplas Y, Hauser B, Salvatore S. Functional gastrointestinal disorders in infancy: impact on the health of the infant and family. Pediatr Gastroenterol Hepatol Nutr 2019;22:207-16. https://doi.org/10.5223/pghn.2019.22.3.207
- Gelfand AA, Goadsby PJ, Allen IE. The relationship between migraine and infant colic: a systematic review and meta-analysis. Cephalalgia 2015;35:63-72. https://doi.org/10.1177/0333102414534326
- Martin AJ, Pratt N, Kennedy JD, Ryan P, Ruffin RE, Miles H, et al. Natural history and familial relationships of infant spilling to 9 years of age. Pediatrics 2002;109:1061-7. https://doi.org/10.1542/peds.109.6.1061
- Savino F, Castagno E, Bretto R, Brondello C, Palumeri E, Oggero R. A prospective 10-year study on children who had severe infantile colic. Acta Paediatr Suppl 2005;94:129-32. https://doi.org/10.1111/j.1651-2227.2005.tb02169.x
- Vandenplas Y, Benninga M, Broekaert I, Falconer J, Gottrand F, Guarino A, et al. Functional gastrointestinal disorder algorithms focus on early recognition, parental reassurance and nutritional strategies. Acta Paediatr 2016;105:244-52. https://doi.org/10.1111/apa.13270
- Mahon J, Lifschitz C, Ludwig T, Thapar N, Glanville J, Miqdady M, et al. The costs of functional gastrointestinal disorders and related signs and symptoms in infants: a systematic literature review and cost calculation for England. BMJ Open 2017;7:e015594.
- Barbieur J, Levy EI, Vandenplas Y. Efficacy and safety of medical and nutritional management of gastroesophageal reflux in formula-fed infants: a narrative review. Curr Opin Pediatr 2022;34:503-9. https://doi.org/10.1097/MOP.0000000000001147
- Salvatore S, Abkari A, Cai W, Catto-Smith A, Cruchet S, Gottrand F, et al. Review shows that parental reassurance and nutritional advice help to optimise the management of functional gastrointestinal disorders in infants. Acta Paediatr 2018;107:1512-20. https://doi.org/10.1111/apa.14378
- Rosen R, Vandenplas Y, Singendonk M, Cabana M, DiLorenzo C, Gottrand F, et al. Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr 2018;66:516-54. https://doi.org/10.1097/MPG.0000000000001889
- Salvatore S, Savino F, Singendonk M, Tabbers M, Benninga MA, Staiano A, et al. Thickened infant formula: What to know. Nutrition 2018;49:51-6. https://doi.org/10.1016/j.nut.2017.10.010
- Vandenplas Y, Hachimi-Idrissi S, Casteels A, Mahler T, Loeb H. A clinical trial with an "anti-regurgitation" formula. Eur J Pediatr 1994;153:419-23.
- Tounian P, Meunier L, Speijers G, Oozeer R, Vandenplas Y. Effectiveness and tolerance of a locust bean gum-thickened formula: a real-life study. Pediatr Gastroenterol Hepatol Nutr 2020;23:511-20. https://doi.org/10.5223/pghn.2020.23.6.511
- Miyazawa R, Tomomasa T, Kaneko H, Arakawa H, Morikawa A. Effect of formula thickened with reduced concentration of locust bean gum on gastroesophageal reflux. Acta Paediatr 2007;96:910-4. https://doi.org/10.1111/j.1651-2227.2007.00279.x
- Bellaiche M, Ludwig T, Arciszewska M, Bongers A, Gomes C, wiat A, et al. Safety and tolerance of a novel anti-regurgitation formula: a double-blind, randomized, controlled trial. J Pediatr Gastroenterol Nutr 2021;73:579-85. https://doi.org/10.1097/MPG.0000000000003289
- Salminen S, Stahl B, Vinderola G, Szajewska H. Infant formula supplemented with biotics: current knowledge and future perspectives. Nutrients 2020;12:1952.
- Huet F, Abrahamse-Berkeveld M, Tims S, Simeoni U, Beley G, Savagner C, et al. Partly fermented infant formulae with specific oligosaccharides support adequate infant growth and are well-tolerated. J Pediatr Gastroenterol Nutr 2016;63:e43-53. https://doi.org/10.1097/MPG.0000000000001360
- Rodriguez-Herrera A, Mulder K, Bouritius H, Rubio R, Munoz A, Agosti M, et al. Gastrointestinal tolerance, growth and safety of a partly fermented formula with specific prebiotics in healthy infants: a double-blind, randomized, controlled trial. Nutrients 2019;11:1530.
- Vandenplas Y, Ludwig T, Bouritius H, Alliet P, Forde D, Peeters S, et al. Randomised controlled trial demonstrates that fermented infant formula with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides reduces the incidence of infantile colic. Acta Paediatr 2017;106:1150-8. https://doi.org/10.1111/apa.13844
- Beghin L, Tims S, Roelofs M, Rouge C, Oozeer R, Rakza T, et al. Fermented infant formula (with Bifidobacterium breve C50 and Streptococcus thermophilus O65) with prebiotic oligosaccharides is safe and modulates the gut microbiota towards a microbiota closer to that of breastfed infants. Clin Nutr 2021;40:778-87. https://doi.org/10.1016/j.clnu.2020.07.024
- World Health Organization (WHO). WHO child growth standards: length/height-for-age, weight-forage, weight-for-length, weight-for-height and body mass index-for-age: methods and development [Internet]. WHO; 2006 Nov 11 [cited 2022 Jun 7]. Available from: https://www.who.int/publications/i/item/924154693X
- Huysentruyt K, Koppen I, Benninga M, Cattaert T, Cheng J, De Geyter C, et al. The brussels infant and toddler stool scale: a study on interobserver reliability. J Pediatr Gastroenterol Nutr 2019;68:207-13. https://doi.org/10.1097/MPG.0000000000002153
- Vandenplas Y, Szajewska H, Benninga M, Di Lorenzo C, Dupont C, Faure C, et al. Development of the brussels infant and toddler stool scale ('BITSS'): protocol of the study. BMJ Open 2017;7:e014620.
- Dupont C, Vandenplas Y, Group SS Efficacy and tolerance of a new anti-regurgitation formula. Pediatr Gastroenterol Hepatol Nutr 2016;19:104-9. https://doi.org/10.5223/pghn.2016.19.2.104
- Huang Y, Tan SY, Parikh P, Buthmanaban V, Rajindrajith S, Benninga MA. Prevalence of functional gastrointestinal disorders in infants and young children in China. BMC Pediatr 2021;21:131.
- Bellaiche M, Ategbo S, Krumholz F, Ludwig T, Miqdady M, Abkari A, et al. A large-scale study to describe the prevalence, characteristics and management of functional gastrointestinal disorders in African infants. Acta Paediatr 2020;109:2366-73. https://doi.org/10.1111/apa.15248
- Zeevenhooven J, Browne PD, L'Hoir MP, de Weerth C, Benninga MA. Infant colic: mechanisms and management. Nat Rev Gastroenterol Hepatol 2018;15:479-96. https://doi.org/10.1038/s41575-018-0008-7
- Hofman D, Kudla U, Miqdady M, Nguyen TVH, Moran-Ramos S, Vandenplas Y. Faecal microbiota in infants and young children with functional gastrointestinal disorders: a systematic review. Nutrients 2022;14:974.
- Moretti E, Rakza T, Mestdagh B, Labreuche J, Turck D. The bowel movement characteristics of exclusively breastfed and exclusively formula fed infants differ during the first three months of life. Acta Paediatr 2019;108:877-81. https://doi.org/10.1111/apa.14620
- Scholtens PA, Goossens DA, Staiano A. Stool characteristics of infants receiving short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides: a review. World J Gastroenterol 2014;20:13446-52. https://doi.org/10.3748/wjg.v20.i37.13446
- Vandenplas Y, De Greef E, Veereman G. Prebiotics in infant formula. Gut Microbes 2014;5:681-7. https://doi.org/10.4161/19490976.2014.972237
- Kurth E, Kennedy HP, Spichiger E, Hosli I, Stutz EZ. Crying babies, tired mothers: what do we know? a systematic review. Midwifery 2011;27:187-94. https://doi.org/10.1016/j.midw.2009.05.012
- Brown M, Heine RG, Jordan B. Health and well-being in school-age children following persistent crying in infancy. J Paediatr Child Health 2009;45:254-62. https://doi.org/10.1111/j.1440-1754.2009.01487.x
- Rautava P, Lehtonen L, Helenius H, Sillanpaa M. Infantile colic: child and family three years later. Pediatrics 1995;96:43-7. https://doi.org/10.1542/peds.96.1.43
- Scherdel P, Botton J, Rolland-Cachera MF, Leger J, Pele F, Ancel PY, et al. Should the WHO growth charts be used in France? PLoS One 2015;10:e0120806.
- Barr RG. Colic and crying syndromes in infants. Pediatrics 1998;102:1282-6. https://doi.org/10.1542/peds.102.SE1.1282
- Iglowstein I, Jenni OG, Molinari L, Largo RH. Sleep duration from infancy to adolescence: reference values and generational trends. Pediatrics 2003;111:302-7. https://doi.org/10.1542/peds.111.2.302
- Hegar B, Rantos R, Firmansyah A, De Schepper J, Vandenplas Y. Natural evolution of infantile regurgitation versus the efficacy of thickened formula. J Pediatr Gastroenterol Nutr 2008;47:26-30. https://doi.org/10.1097/MPG.0b013e31815eeae9