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The potential of Panax notoginseng against COVID-19 infection

  • Yeye Hu (Institute of Translational Medicine, School of Medicine, Yangzhou University) ;
  • Ziliang He (School of Life Sciences, Huaiyin Normal University) ;
  • Wei Zhang (School of Life Sciences, Huaiyin Normal University) ;
  • Zhiqiang Niu (Institute of Translational Medicine, School of Medicine, Yangzhou University) ;
  • Yanting Wang (Institute of Translational Medicine, School of Medicine, Yangzhou University) ;
  • Ji Zhang (School of Life Sciences, Huaiyin Normal University) ;
  • Ting Shen (Institute of Translational Medicine, School of Medicine, Yangzhou University) ;
  • Hong Cheng (Institute of Translational Medicine, School of Medicine, Yangzhou University) ;
  • Weicheng Hu (Institute of Translational Medicine, School of Medicine, Yangzhou University)
  • Received : 2022.11.19
  • Accepted : 2023.04.05
  • Published : 2023.09.01

Abstract

The COVID-19 pandemic has changed the world and has presented the scientific community with unprecedented challenges. Infection is associated with overproduction of proinflammatory cytokines secondary to hyperactivation of the innate immune response, inducing a cytokine storm and triggering multiorgan failure and significant morbidity/mortality. No specific treatment is yet available. For thousands of years, Panax notoginseng has been used to treat various infectious diseases. Experimental evidence of P. notoginseng utility in terms of alleviating the cytokine storm, especially the cascade, and improving post-COVID-19 symptoms, suggests that P. notoginseng may serve as a valuable adjunct treatment for COVID-19 infection.

Keywords

Acknowledgement

This study was financially supported by Natural Science Foundation of Jiangsu Province (BK20201480).

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