Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Study for Enhanced Skin Penetration of Cosmetics by Plasma-Sono Stimuli

플라즈마-초음파 자극에 의한 화장품의 피부 침투 증진 연구

  • Yoonho Hwang (Derpartment of Biomedical Engineering, Yonsei University) ;
  • Hyeyoun Cho (Derpartment of Biomedical Engineering, Yonsei University) ;
  • Yujin Park (Derpartment of Biomedical Engineering, Yonsei University) ;
  • Hwijin Jang (Derpartment of Biomedical Engineering, Yonsei University) ;
  • Sanghyo Park (Derpartment of Biomedical Engineering, Yonsei University) ;
  • Jaehong Key (Derpartment of Biomedical Engineering, Yonsei University)
  • Received : 2023.08.09
  • Accepted : 2023.08.18
  • Published : 2023.08.31
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Abstract

The demand for skincare has increased due to the end of the COVID-19 pandemic, leading to a focus on skincare devices and technologies designed to improve the delivery of cosmetics. Among these technologies, skincare medical devices that utilize plasma therapy (Plasma) and sonophoresis (Sono) are commonly used in dermatology clinics. However, there is still a lack of quantitative analysis for transdermal absorption effects of Plasma and Sono skincare medical devices. In this study, we quantified enhanced transdermal absorption effects of Plasma and Sono devices through in-silico and ex-vivo studies. The Sono treatment demonstrated an increased transdermal absorption effect, showing a 10~13% difference in penetration compared to the control group in the in-silico experiment, and 159% and 184% increase in the ex-vivo experiment. The Plasma treatment revealed increased transdermal absorption effects, with a 1.0~2.5% penetration difference in the in-silico experiment, and a 124% increase in the ex-vivo experiment compared to the control group. We also observed a synergistic effect from the combined treatment of Plasma and Sono, as indicated by the highest increases of 197% and 242% in penetration. Furthermore, we have determined the optimal device settings and treatment conditions for Plasma-Sono skincare medical devices. Notably, higher on/off durations (Intensity levels) and longer Sono treatments resulted in greater transdermal absorption effects.

Keywords

Acknowledgement

본 연구는 과학기술정보통신부 및 교육부의 재원으로 한국연구재단의 지원을 받아 수행된 연구임(No. 2022R1F1A1069516, 2022RIS005).

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