Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Non-B, Non-T Acute Lymphoblastic Leukemia in a Cat

  • Sumin Cha (College of Veterinary Medicine, Gyeongsang National University) ;
  • Hyunwoo Kim (Noah Animal Medical Center) ;
  • Hyeona Bae (College of Veterinary Medicine, Gyeongsang National University) ;
  • Minjeong Kang (College of Veterinary Medicine, Gyeongsang National University) ;
  • Rankyung Jung (College of Veterinary Medicine, Gyeongsang National University) ;
  • Minji Kim (College of Veterinary Medicine, Gyeongsang National University) ;
  • DoHyeon Yu (College of Veterinary Medicine, Gyeongsang National University)
  • Received : 2023.08.04
  • Accepted : 2023.08.14
  • Published : 2023.08.31
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Abstract

A 7-year-old neutered male, domestic shorthair cat presented anorexia and lethargy. The complete blood cell count revealed severe non-regenerative anemia, lymphocytic leukocytosis, neutropenia, and thrombocytopenia. On the peripheral blood smear examination, medium to large lymphoblastic cells with moderate amounts of basophilic cytoplasm were observed in up to 70% of peripheral leukocytes. Feline leukemia and immunodeficiency viruses were not detected using a commercial diagnostic kit. While splenomegaly and blunt margins of the caudoventral liver were observed in abdominal radiography, changes in the intra-abdominal lymph nodes were not remarkable. Ultimately, flow cytometric immunophenotyping from the peripheral blood revealed a negative for B-cell markers (CD21-/CD79a-) and T-cell markers (CD3-/CD4-/CD5-/CD8-). Based on the hematological examination and the immunophenotyping assay, the cat was diagnosed with non-B, non-T acute lymphoblastic leukemia. Here, we report a rare case of non-B, non-T acute lymphoblastic leukemia to raise awareness and provide information on clinical symptoms and laboratory test and immunophenotyping analysis results.

Keywords

Acknowledgement

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2020R1C1C1008675).

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