한방안이비인후피부과학회지 (The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology)

  • 제36권3호
  • /
  • Pages.99-118
  • /
  • 2023
  • /
  • 1738-6640(pISSN)
  • /
  • 2234-4020(eISSN)
대한한방안이비인후피부과학회 (The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology)
권호 표지
DOI QR코드

DOI QR Code

면역학적 이해를 통한 건선의 한약 치료 고찰

A Study on Herbal Medicine Treatment of Psoriasis through Immunological Understanding

  • 남혜진 (울산자생한방병원 안이비인후피부과) ;
  • 박혜리 (동국대학교 한의과대학) ;
  • 조준범 (동국대학교 한의과대학) ;
  • 박신영 (동국대학교 한의과대학) ;
  • 임유라 (해운대자생한방병원 안이비인후피부과)
  • Hye-Jin Nam (Dep. of Ophthalmology & Otolaryngology & Dermatology, Ulsan Jaseng Hospital of Korean Medicine) ;
  • Hyeli Park (Dongguk University Oriental Medical school) ;
  • Junbum Cho (Dongguk University Oriental Medical school) ;
  • Shinyoung Park (Dongguk University Oriental Medical school) ;
  • Yu-Ra Im (Dep. of Ophthalmology & Otolaryngology & Dermatology, Haeundae Jaseng Hospital of Korean Medicine)
  • 투고 : 2023.06.08
  • 심사 : 2023.08.07
  • 발행 : 2023.08.25
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objectives : The purpose of this review is to investigate the effect of herbal medicine treatment on cytokines and symptom improvement in patients with psoriasis. Methods : We searched four web databases for studies on psoriasis treated with herbal medicines published from 2000 to April 2023. After searching for studies, we analyzed selected studies based on inclusion criteria. Results : Seven randomized controlled trials have been found and analyzed. All of research which selected have reported that herbal medicine treatment for psoriasis patients have an effect on cytokines and was effective in improving symptoms, and all were statistically significant. Conclusions : According to the results, herbal medicine treatment can be an effective treatment for improving symptoms and cytokines in patients with psoriasis. This study will be helpful for future research in herbal medicine.

키워드

참고문헌

  1. Greb JE, Goldminz AM, Elder JT, Lebwohl MG, Gladman DD, Wu JJ, et al. Psoriasis(Primer). Nature Reviews:Disease Primers. 2016;2(1):16082.
  2. Placek W, Haftek M, Thivolet J. Sequence of changes in psoriatic epidermis. Immunocompetent cell redistribution precedes altered expression of keratinocyte differentiation markers. Acta dermatovenereologica. 1988;68(5):369-77.
  3. Weinshenker BG, Bass BH, Ebers GC, Rice G. Remission of psoriatic lesions with muromonab-CD3 (orthoclone OKT3) treatment. Journal of the American Academy of Dermatology. 1989;20(6):1132,1133.
  4. Nicolas J, Bour H, Thivolet J, Schmitt D, Claudy A. Immunotherapy of psoriasis with anti-CD4 monoclonal antibodies. Acta Dermato Venereologica-Supplement. 1994;7(1):1-13.
  5. Gardembas-Pain M, Ifrah N, Foussard C, Boasson M, Saint-Andre JP, Verret JL. Psoriasis after allogeneic bone marrow transplantation. Archives of dermatology. 1990;126(11):1523.
  6. Prinz JC, Gross B, Vollmer S, Trommler P, Strobel I, Meurer M, et al. T cell clones from psoriasis skin lesions can promote keratinocyte proliferation in vitro via secreted products. European journal of immunology. 1994;24(3):593-8. https://doi.org/10.1002/eji.1830240315
  7. Sung KJ, Kim HS, Seo JH, Choi JH. Distribution of T lymphocyte Subpopulations in P soriatic Skin. Korean Journal of Dermatology. 1997;35(3):435-42.
  8. Lee KY, Jeon SY, Ko DY, Song KH, Kim KH. The Expression of Cytokine and Chemokine Related with Dendritic Cell and Effector T Cell in Psoriatic Lesions. Korean Journal of Dermatology. 2012;50(7):599-608.
  9. Yoon SW. Recent medical therapy for psoriasis. Journal of the Korean Medical Association. 2019;62(3):176-80. https://doi.org/10.5124/jkma.2019.62.3.176
  10. Solomon DH, Glynn RJ, Karlson EW, Lu F, Corrigan C, Colls J, et al. Adverse effects of low-dose methotrexate: a randomized trial. Annals of internal medicine. 2020;172(6):369-80. https://doi.org/10.7326/M19-3369
  11. Gollnick H. Oral retinoids efficacy and toxicity in psoriasis. British Journal of Dermatology. 1996;135:6-17. https://doi.org/10.1111/j.1365-2133.1996.tb15661.x
  12. Gomez-Reino JJ, Carmona L, Valverde VR, Mola EM, Montero MD. Treatment of rheumatoid arthritis with tumor necrosis factor inhibitors may predispose to significant increase in tuberculosis risk: a multicenter active-surveillance report. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology. 2003;48(8):2122-7.
  13. Xi C, Runtian Z, Xingwu D, Ming X, Tiange Q, Lingling L. Effectiveness of Xiaoyin Jiedu granules in the treatment of psoriasis vulgaris in patients with blood-heat symptom patterns in terms of Traditional Chinese Medicine. Journal of Traditional Chinese Medicine. 2020;40(5):863.
  14. Lei M. Enhanced Effect of Qing-Ying Decoction Concurrent with Secukinumab in the Treatment of Plaque Psoriasis. Alternative Therapies in Health and Medicine. 2022;28(6):96-102.
  15. Xing Y, Guo J, Guo W. Cooling blood detoxification decoction and nursing countermeasures in the treatment of acute psoriasis from the perspective of immune function and inflammatory factors. Pakistan Journal of Pharmaceutical Sciences. 2021;34:2341-5.
  16. Zhang BX, Wang L, Wang QX, Tu YH, Li J. Clinical study of modified Yiyi Baijiang Decoction on psoriasis vulgaris due to dampness-heat accumulation. Zhongguo Zhongyao Zazhi. 2022;47(11):3105-10.
  17. Wang L, Fang YP, Zhou GX, Wu PH, Li QJ, Geng QN. Study on clinical efficacy and mechanism of Qingying Tang for treating psoriatic blood-heat syndrome based on IL-23/Th17. Zhongguo Zhongyao Zazhi. 2019;44(1):175-80.
  18. Wen CH, Jia M, Zhang S, Ma ZF, Tang TC. Study of Xiaobi decoction (empirical formula of professor Jia Min) in the treatment of psoriasis vulgaris. China Modern Medicine. 2016;23(9):28-31.
  19. Cai Y, Li K, Zou J, Zhang X, Xu L, Han L, et al. Clinical Research of Psoriasis Belonging to Blood Heat Syndrome Treated with Xiaoyin Jiedu Bag Decoction. Chinese Journal of Traditional Medical Science and Technology. 2020;27(1):12-4.
  20. Song HJ, Park CJ, Kim TY, Choe YB, Lee SJ, Kim NI, et al. The clinical profile of patients with psoriasis in Korea: A nationwide cross-sectional study(EPI-PSODE). Annals of Dermatology. 2017;29(4):462-70. https://doi.org/10.5021/ad.2017.29.4.462
  21. Boyman O, Conrad C, Tonel G, Gilliet M, Nestle FO. The pathogenic role of tissue-resident immune cells in psoriasis. Trends in immunology. 2007;28(2):51-7. https://doi.org/10.1016/j.it.2006.12.005
  22. Choi JW, Kim BR, Seo E, Youn SW. Could psoriatic arthritis be easily diagnosed from current suspicious physical findings in the dermatology clinic? Annals of Dermatology. 2017;29(1):48-54. https://doi.org/10.5021/ad.2017.29.1.48
  23. Youn SW, Kang SY, Kim SA, Park GY, Lee WW. Subclinical systemic and vascular inflammation detected by 18Ffluorodeoxyglucose positron emission tomography/computed tomography in patients with mild psoriasis. The Journal of Dermatology. 2015;42(6):559-66. https://doi.org/10.1111/1346-8138.12859
  24. Boehncke WH, Schon MP. Psoriasis. The Lancet. 2015;386(9997):983-94. https://doi.org/10.1016/S0140-6736(14)61909-7
  25. Youn JI. Psoriasis in Korean. Korean Journal of Dermatology. 2012;50(5):387-402.
  26. Zhang K, Zhang R, Duan H, Chen XI. Study on the Regulation of Xiaoyin Jiedu Granule on Peripheral Blood T Cell Subset Th17 and Its Related Inflammatory Factors in Psoriasis Blood-Heat Syndrome. World Chinese Medicine. 2019;14(4):891-4.
  27. Jiu R, Chen C, Fan G, Sun Z, Ni J, Sun B. Study on Pharmacological Effects of Rhino Horn and Buffalo Horn. Chinese Patent Medicine. 1997;19(7):33,34.
  28. Liu X, Sun X, Qi X, Lin X. Effects of 20 herbs on mouse epithelial cells proliferation, epidermal cells differentiation and plasma endothelin-1. Chinese Journal Of Dermatology. 2001;34(4):282,283.
  29. Zhang Y, Qu X, Niu F. Affects of 8 kinds of Chinese herbs on the growth and interleukin-8 production of keratinocytes stimulated by tumor necrosis factor-α. Chin J Dermatol Venerol Integr Tradit West Med(Chin). 2006;5:18-20.
  30. The professors of Bonchohakco-authorship. Bonchohakco. Seoul:Yeonglim's Publisher. 2004:231-645.
  31. Park KD. Use of retinoids in dermatology. Journal of the Korean Medical Association. 2022;65(5):299-306. https://doi.org/10.5124/jkma.2022.65.5.299
  32. Youn JI. Treatment of Psoriasis. Journal of the Korean Medical Association. 2006;49(2):150-60. https://doi.org/10.5124/jkma.2006.49.2.150
  33. Lu Z. Clinical effect of modified Qingying decoction in treating 62 patients with psoriasis. Nei Mongol Journal of Traditional Chinese Medicine. 2015;34(5):19.
  34. Chen GS. The Therapeutic Effects of Pyrithione Zinc Aerosol Combined with Diyin Tablet on Treating Psoriasis Vulgaris. The Chinese Journal Of Dermatovenereology. 2008;22(6):385,386.
  35. Cheng HM, Wu YC, Wang Q, Song M, Wu J, Chen D, et al. Clinical efficacy and IL-17 targeting mechanism of Indigo naturalis as a topical agent in moderate psoriasis. BMC complementary and alternative medicine. 2017;17(1):1-11. https://doi.org/10.1186/s12906-016-1505-2
  36. Youn SW, Choi CW, Kim BR, Chae JB. Reduction of inter-rater and intra-rater variability in psoriasis area and severity index assessment by photographic training. Annals of Dermatology. 2015;27(5):557-62. https://doi.org/10.5021/ad.2015.27.5.557
  37. McGeachy MJ, Cua DJ, Gaffen SL. The IL-17 family of cytokines in health and disease. Immunity. 2019;50(4):892-906. https://doi.org/10.1016/j.immuni.2019.03.021
  38. Chiricozzi A, Guttman-Yassky E, Suarez-Farinas M, Nograles KE, Tian S, Cardinale I, et al. Integrative responses to IL-17 and TNF-α in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis. Journal of Investigative Dermatology. 2011;131(3):677-87. https://doi.org/10.1038/jid.2010.340
  39. Burnet M. The helper T-cell responses. 4th ed. Philadelphia:Saunders. 1995:139-54.
  40. Austin LM, Covens TR, Bhardwaj N, Steinman R, Krueger JG. Intraepidermal lymphocytes in psoriatic lesions are activated GMP-17 (TIA-1)+ CD8+ CD3+ CTLs as determined by phenotypic analysis. Journal of cutaneous pathology. 1998;25(2):79-88. https://doi.org/10.1111/j.1600-0560.1998.tb01694.x
  41. Ferenczi K, Burack L, Pope M, Krueger J, Austin L. CD69, HLA-DR and the IL-2R identify persistently activated T cells in psoriasis vulgaris lesional skin: blood and skin comparisons by flow cytometry. Journal of autoimmunity. 2000;14(1):63-78. https://doi.org/10.1006/jaut.1999.0343
  42. Hu P, Wang M, Gao H, Zheng A, Li J, Mu D, et al. The role of helper T cells in psoriasis. Frontiers in immunology. 2021;12:788940.
  43. Kapp A. Elevated levels of soluble CD8 antigen in sera of patients with psoriasis-a possible sign of suppressor/cytotoxic T-cell activation. Archives of dermatological research. 1990;282:6,7.
  44. Nanney LB, Stoscheck CM, Magid M, King Jr LE. Altered [125I] epidermal growth factor binding and receptor distribution in psoriasis. Journal of investigative dermatology. 1986;86(3):260-5. https://doi.org/10.1111/1523-1747.ep12285389
  45. Wei Q, Zheng N, Sun Q. Expression and significance of vascular endothelial growth factor and cyclooxygenase-2 in skin lesions of patients with psoriasis vulgaris. Journal of clinical dermatology. 2013;42(8):464,465.
  46. Chae BS, Shin TY. Effect of Fresh Rehmanniae Radix Methanol Extracts on the Production of Cytokines. Yakhak Hoeji. 2006;50(3):184-90.
  47. Mok JY, Jeon IH, Kim HS, Shin JH, Park YG, Jang SI. Synergic Anti-Pruritic and Anti-Inflammatory Effects of Scutellariae Radix plus Flos Loncerae Extracts in Rat Peritoneal Mast Cell and Chemical Antigen-Induced Mice. Journal of Physiology & Pathology in Korean Medicine. 2013;27(1):83-91.
  48. Asadullah K, Sterry W, Volk HD. Interleukin-10 therapy-review of a new approach. Pharmacological reviews. 2003;55(2):241-69. https://doi.org/10.1124/pr.55.2.4
  49. Hwang IS, Kim YJ, Park YS, Kim HJ, Kim DH, Park WS. Anti-inflammatory Effect of Houttuyniae Herba Water Extract on LPS-induced RAW 264.7 Mouse Macrophages. The Korea Journal of Herbology. 2014;29(4):83-9. https://doi.org/10.6116/kjh.2014.29.4.83