Physical Therapy Korea (한국전문물리치료학회지)

Korean Research Society of Physical Therapy (한국전문물리치료학회)
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Relationship Between Muscle Mass and Usual Walking Speed Mediated by Muscle Strength, Respiration and Depression in Elderly Female

  • Yun-jeong Baek (Department of Rehabilitation Medicine, Seoul National University Bundang Hospital) ;
  • Chung-hwi Yi (Department of Physical Therapy, College of Health Sciences, Yonsei University) ;
  • Oh-yun Kwon (Department of Physical Therapy, College of Health Sciences, Yonsei University) ;
  • Sang-hyun Cho (Department of Physical Therapy, College of Health Sciences, Yonsei University)
  • Received : 2023.08.01
  • Accepted : 2023.08.07
  • Published : 2023.08.20
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Abstract

Background: The elderly population is increasing rapidly worldwide. Muscle mass, usual walking speed (UWS), knee extension strength (KES), hand grip strength (HGS), peak expiratory flow (PEF), and depression is used for sarcopenia diagnosis. All four of these factors (KES, HGS, PEF, and depression) correlated with UWS and also to muscle mass. But, many studies have suggested that no correlation exists between muscle mass and UWS. Objects: This study aimed: 1) to investigate whether muscle mass reduction affected UWS, as mediated by KES, HGS, PEF and depression, and 2) to explored whether significant changes in these mediators varied by the body segment in which muscle mass evaluated in elderly female aged 65-80 years. Methods: A total of 100 female aged 65-80 years were surveyed. Muscle mass was measured by body segment (upper and lower segment), and KES, HGS, PEF, depression, and UWS were also assessed. Median analyses were progressed in IBM SPSS software (ver. 23.0, IBM Co.) using a downloaded INDIRECT macro. Results: The direct effect of the KES and PEF were significant, and the indirect effect of KES and PEF were not significant. Thus, KES and PEF served as full mediators of the effect of muscle mass on UWS. Regardless of bodily region, KES and PEF combined with muscle mass were significant mediators of UWS, with similar indirect effect sizes. Conclusion: KES and PEF are the only mediators regardless of body part. Therefore, mediating the KES and PEF may prevent sarcopenia progression in elderly female. Also, sarcopenia can be readily assessed by evaluating either the upper or lower body; it is not necessary to measure total muscle mass.

Keywords

References

  1. Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyere O, Cederholm T, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 2019;48(1):16-31. Erratum in: Age Ageing 2019;48(4):601.
  2. Chen LK, Liu LK, Woo J, Assantachai P, Auyeung TW, Bahyah KS, et al. Sarcopenia in Asia: consensus report of the Asian Working Group for Sarcopenia. J Am Med Dir Assoc 2014;15(2):95-101. https://doi.org/10.1016/j.jamda.2013.11.025
  3. Wilson D, Jackson T, Sapey E, Lord JM. Frailty and sarcopenia: the potential role of an aged immune system. Ageing Res Rev 2017;36:1-10. https://doi.org/10.1016/j.arr.2017.01.006
  4. Kim JH, Lim S, Choi SH, Kim KM, Yoon JW, Kim KW, et al. Sarcopenia: an independent predictor of mortality in community-dwelling older Korean men. J Gerontol A Biol Sci Med Sci 2014;69(10):1244-52. https://doi.org/10.1093/gerona/glu050
  5. Delmonico MJ, Harris TB, Lee JS, Visser M, Nevitt M, Kritchevsky SB, et al.; Health, Aging and Body Composition Study. Alternative definitions of sarcopenia, lower extremity performance, and functional impairment with aging in older men and women. J Am Geriatr Soc 2007;55(5):769-74. https://doi.org/10.1111/j.1532-5415.2007.01140.x
  6. Goodpaster BH, Park SW, Harris TB, Kritchevsky SB, Nevitt M, Schwartz AV, et al. The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study. J Gerontol A Biol Sci Med Sci 2006;61(10):1059-64. https://doi.org/10.1093/gerona/61.10.1059
  7. Chen LK, Woo J, Assantachai P, Auyeung TW, Chou MY, Iijima K, et al. Asian Working Group for Sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment. J Am Med Dir Assoc 2020;21(3):300-7.e2. https://doi.org/10.1016/j.jamda.2019.12.012
  8. Kitamura I, Koda M, Otsuka R, Ando F, Shimokata H. Six-year longitudinal changes in body composition of middle-aged and elderly Japanese: age and sex differences in appendicular skeletal muscle mass. Geriatr Gerontol Int 2014;14(2):354-61. https://doi.org/10.1111/ggi.12109
  9. Hardy SE, Perera S, Roumani YF, Chandler JM, Studenski SA. Improvement in usual gait speed predicts better survival in older adults. J Am Geriatr Soc 2007;55(11):1727-34. https://doi.org/10.1111/j.1532-5415.2007.01413.x
  10. Liu B, Hu X, Zhang Q, Fan Y, Li J, Zou R, et al. Usual walking speed and all-cause mortality risk in older people: a systematic review and meta-analysis. Gait Posture 2016;44:172-7. https://doi.org/10.1016/j.gaitpost.2015.12.008
  11. Perry J, Garrett M, Gronley JK, Mulroy SJ. Classification of walking handicap in the stroke population. Stroke 1995;26(6):982-9. https://doi.org/10.1161/01.STR.26.6.982
  12. Studenski S, Perera S, Wallace D, Chandler JM, Duncan PW, Rooney E, et al. Physical performance measures in the clinical setting. J Am Geriatr Soc 2003;51(3):314-22. https://doi.org/10.1046/j.1532-5415.2003.51104.x
  13. Fritz S, Lusardi M. White paper: "walking speed: the sixth vital sign". J Geriatr Phys Ther 2009;32(2):46-9. Erratum in: J Geriatr Phys Ther 2009;32(3):110.
  14. Manini TM, Visser M, Won-Park S, Patel KV, Strotmeyer ES, Chen H, et al. Knee extension strength cutpoints for maintaining mobility. J Am Geriatr Soc 2007;55(3):451-7. https://doi.org/10.1111/j.1532-5415.2007.01087.x
  15. Bean JF, Kiely DK, Herman S, Leveille SG, Mizer K, Frontera WR, et al. The relationship between leg power and physical performance in mobility-limited older people. J Am Geriatr Soc 2002;50(3):461-7. https://doi.org/10.1046/j.1532-5415.2002.50111.x
  16. Fragala MS, Alley DE, Shardell MD, Harris TB, McLean RR, Kiel DP, et al. Comparison of handgrip and leg extension strength in predicting slow gait speed in older adults. J Am Geriatr Soc 2016;64(1):144-50. https://doi.org/10.1111/jgs.13871
  17. Lee MC, Hsu CC, Tsai YF, Chen CY, Lin CC, Wang CY. Criterion-referenced values of grip strength and usual gait speed using instrumental activities of daily living disability as the criterion. J Geriatr Phys Ther 2018;41(1):14-9. https://doi.org/10.1519/JPT.0000000000000106
  18. Auyeung TW, Lee SW, Leung J, Kwok T, Woo J. Age-associated decline of muscle mass, grip strength and gait speed: a 4-year longitudinal study of 3018 community-dwelling older Chinese. Geriatr Gerontol Int 2014;14 Suppl 1:76-84. https://doi.org/10.1111/ggi.12213
  19. Kera T, Kawai H, Hirano H, Kojima M, Fujiwara Y, Ihara K, et al. Relationships among peak expiratory flow rate, body composition, physical function, and sarcopenia in community-dwelling older adults. Aging Clin Exp Res 2018;30(4):331-40. https://doi.org/10.1007/s40520-017-0777-9
  20. Ridwan ES, Wiratama BS, Lin MY, Hou WH, Liu MF, Chen CM, et al. Peak expiratory flow rate and sarcopenia risk in older Indonesian people: a nationwide survey. PLoS One 2021;16(2):e0246179.
  21. Sanders JB, Bremmer MA, Comijs HC, Deeg DJ, Beekman AT. Gait speed and the natural course of depressive symptoms in late life; an independent association with chronicity? J Am Med Dir Assoc 2016;17(4):331-5. https://doi.org/10.1016/j.jamda.2015.11.016
  22. Wu H, Yu B, Meng G, Liu F, Guo Q, Wang J, et al. Both muscle mass and muscle strength are inversely associated with depressive symptoms in an elderly Chinese population. Int J Geriatr Psychiatry 2017;32(7):769-78. https://doi.org/10.1002/gps.4522
  23. Liu LK, Lee WJ, Liu CL, Chen LY, Lin MH, Peng LN, et al. Age-related skeletal muscle mass loss and physical performance in Taiwan: implications to diagnostic strategy of sarcopenia in Asia. Geriatr Gerontol Int 2013;13(4):964-71. https://doi.org/10.1111/ggi.12040
  24. Santos L, Ribeiro AS, Schoenfeld BJ, Nascimento MA, Tomeleri CM, Souza MF, et al. The improvement in walking speed induced by resistance training is associated with increased muscular strength but not skeletal muscle mass in older women. Eur J Sport Sci 2017;17(4):488-94. https://doi.org/10.1080/17461391.2016.1273394
  25. Barbat-Artigas S, Pinheiro Carvalho L, Rolland Y, Vellas B, Aubertin-Leheudre M. Muscle strength and body weight mediate the relationship between physical activity and usual gait speed. J Am Med Dir Assoc 2016;17(11):1031-6. https://doi.org/10.1016/j.jamda.2016.06.026
  26. Kim JH, Choi SH, Lim S, Kim KW, Lim JY, Cho NH, et al. Assessment of appendicular skeletal muscle mass by bioimpedance in older community-dwelling Korean adults. Arch Gerontol Geriatr 2014;58(3):303-7. https://doi.org/10.1016/j.archger.2013.11.002
  27. Aparicio VA, Ortega FB, Heredia JM, Carbonell-Baeza A, Sjostrom M, Delgado-Fernandez M. Handgrip strength test as a complementary tool in the assessment of fibromyalgia severity in women. Arch Phys Med Rehabil 2011;92(1):83-8. https://doi.org/10.1016/j.apmr.2010.09.010
  28. Kamath SU, Vivek N, Gowtham KR. Motor function outcome assessment by grip and pinch strength following carpal tunnel release. Indian J Sci Technol 2016;9(4):56916.
  29. Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, et al.; European Working Group on Sarcopenia in Older People. Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age Ageing 2010;39(4):412-23. https://doi.org/10.1093/ageing/afq034
  30. Ro HJ, Kim DK, Lee SY, Seo KM, Kang SH, Suh HC. Relationship between respiratory muscle strength and conventional sarcopenic indices in young adults: a preliminary study. Ann Rehabil Med 2015;39(6):880-7.
  31. Jung IK, Kwak DI, Joe SH, Lee HS. A study of standardization of Korean form of Geriatric Depression Scale (KGDS). J Korean Geriatr Psychiatry 1997;1(1):61-72.
  32. Kim JY, Park JH, Lee JJ, Huh Y, Lee SB, Han SK, et al. Standardization of the Korean version of the geriatric depression scale: reliability, validity, and factor structure. Psychiatry Investig 2008;5(4):232-8. https://doi.org/10.4306/pi.2008.5.4.232
  33. Pamoukdjian F, Paillaud E, Zelek L, Laurent M, Levy V, Landre T, et al. Measurement of gait speed in older adults to identify complications associated with frailty: a systematic review. J Geriatr Oncol 2015;6(6):484-96. https://doi.org/10.1016/j.jgo.2015.08.006
  34. Talaei-Khoei M, Fischerauer SF, Jha R, Ring D, Chen N, Vranceanu AM. Bidirectional mediation of depression and pain intensity on their associations with upper extremity physical function. J Behav Med 2018;41(3):309-17. https://doi.org/10.1007/s10865-017-9891-6
  35. Evans WJ, Campbell WW. Sarcopenia and age-related changes in body composition and functional capacity. J Nutr 1993;123(2 Suppl):465-8. https://doi.org/10.1093/jn/123.suppl_2.465
  36. Roberts HC, Denison HJ, Martin HJ, Patel HP, Syddall H, Cooper C, et al. A review of the measurement of grip strength in clinical and epidemiological studies: towards a standardised approach. Age Ageing 2011;40(4):423-9. https://doi.org/10.1093/ageing/afr051
  37. Bohannon RW. Are hand-grip and knee extension strength reflective of a common construct? Percept Mot Skills 2012;114(2):514-8. https://doi.org/10.2466/03.26.PMS.114.2.514-518
  38. Alley DE, Shardell MD, Peters KW, McLean RR, Dam TT, Kenny AM, et al. Grip strength cutpoints for the identification of clinically relevant weakness. J Gerontol A Biol Sci Med Sci 2014;69(5):559-66. https://doi.org/10.1093/gerona/glu011
  39. Ishizaki T, Furuna T, Yoshida Y, Iwasa H, Shimada H, Yoshida H, et al.; TMIG-LISA Research Group. Declines in physical performance by sex and age among nondisabled community-dwelling older Japanese during a 6-year period. J Epidemiol 2011;21(3):176-83. https://doi.org/10.2188/jea.JE20100138
  40. Kim NH, Kim HS, Eun CR, Seo JA, Cho HJ, Kim SG, et al. Depression is associated with sarcopenia, not central obesity, in elderly Korean men. J Am Geriatr Soc 2011;59(11):2062-8. https://doi.org/10.1111/j.1532-5415.2011.03664.x