DOI QR코드

DOI QR Code

Case Report on the Five-year Survival of a Patient with Rectal Cancer Treated with Integrative Medicine After Resection and Chemoradiation Therapy

수술 및 항암 방사선 표준 치료 이후의 한양방 통합치료를 통해 5년 무병생존에 도달한 3기 직장암 환자 1례에 대한 보고

  • Received : 2023.05.30
  • Accepted : 2023.07.10
  • Published : 2023.06.30

Abstract

Objectives: This is a five-year survival and complete response (CR) report on rectal cancer treated with western medicine and Korean traditional medicine. Method: A 25-year-old woman diagnosed with rectal cancer visited ⃝⃝ Korean traditional medicine hospital after neoadjuvant concurrent chemoradiation therapy, chemotherapy, and low anterior resection with regional lymph node dissection. She was treated with Korean traditional medicine, including acupuncture, abdominal moxibustion, wild ginseng pharmacopuncture, and herbal medicine, which was based on integrated medicine therapy (IMT), from January 2018 to February 2022. The tumor size was measured by scanning with computed tomography (CT), magnetic resonance imaging, and positron-emission tomography/CT. Adverse events were evaluated using laboratory conclusion and National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0. Result: During four years of treatment, IMT maintained safety. The patient finally reached five-year survival without any recurrence or complication (CR) on March 11, 2022. Conclusion: We suggest that an integrative approach including Korean traditional medicine can be a meaningful treatment option for rectal cancer. Further studies should be performed to establish the proper treatment protocol of integrative medicine for rectal cancer.

Keywords

References

  1. 보건복지부 증앙암등록본부 2022년 12월 발표자료
  2. 대한의학회. 대장암진료권고안v1.0. 2012.
  3. Wiggers T, de Vries MR, Veeze-Kuypers B. Surgery for loal recurrence of rectal carcinoma. Dis Colon Rectum 1996 Mar;39(3):323-8. https://doi.org/10.1007/BF02049476
  4. Gray R, Barnwell J, McConkey C, Hills RK, Williams NS, Kerr DJ. Adjuvant chemotherapy versus observation in patients with colorectal cancer: a randomized study. Lancet 2007 Dec 15;370(9604):2020-9. https://doi.org/10.1016/S0140-6736(07)61866-2
  5. Bang SH, Son CG. A Clinical Observation of Oriental Medicine-Based Long care for terminal Rectal Cancer Patient with Multiple Metastasis. Korean J Oreien int Med 2008 Sep;29(3):567-73.
  6. Garaci E, Pica F, Matteucci C, Gaziano R, D'Agostini C, Miele MT, et al. Historical review on thymosin α1 in oncology: preclinical and clinical experiences. Expert Opin Biol Ther 2015;15(Suppl 1):S31-9. https://doi.org/10.1517/14712598.2015.1017466
  7. Fritz H, Flower G, Weeks L, Cooley K, Callachan M, McGowan J, et al. Intravenous Vitamin C and cancer: A Systemic review. Intergr cancer Ther 2014 Jul;13(4):280-300. https://doi.org/10.1177/1534735414534463
  8. Kienle GS, Kiene H. Complementary cancer therapy: a systematic review of prospective clinical trials on anthroposophic mistletoe extracts. Eur J Med Res 2007;12(3):103-19.
  9. 赵昌风, 彭磷基, 张子丽, 等. 针灸对结肠癌 肝转移患者外周T淋巴细 胞亚群NK细 胞活性的影响[J]. 中国针灸 2010;30(1):10-2.
  10. Hosseinzade A, Sadeghi O, Naghdipour Biregani A, Soukhtehzari S, Brandt GS, Esmaillzadeh A. Immunomodulatory Effects of Flavonoids: Possible Induction of T CD4+ Regulatory Cells Through Suppression of mTOR Pathway Signaling Activity. Front Immunol 2019 Jan;10:51.
  11. Dai D, Zhang CF, Williams S, Yuan CS, Wang CZ. Ginseng on Cancer: Potential Role in Modulating Inflammation-mediated Angiogenesis. Am J Chin Med 2017;45(1):13-22. https://doi.org/10.1142/S0192415X17500021
  12. Staib L, Link KH, Beger HG. Follow up in colorectal cancer: cost-effectiveness analysis of established and novel concepts. Langenbecks Arch Surg 2000;385(6):412-20. https://doi.org/10.1007/s004230000144
  13. Kim NK, Park JK, Kang YL, Seong HY, Seung KS, Jin SM. Prognostic Factors Influencing the Recurrence Pattern and Survival Rates in Curatively Resected Colorectal Cancer. J Korean Surg Soc 2002;62(5):421-9.
  14. Wong CS, Cummings BJ, Keane TJ, Dobrowsky W, O'Sullivan B, Catton CN. Combined radiation therapy, Mitomycin C, and 5-fluorouracil for locally recurrent rectal carcinoma. Results of a pilot study. Int J Radiat Oncol Biol Phys 1991;21(5):1291-6. https://doi.org/10.1016/0360-3016(91)90288-F
  15. Wong CS, Cummings BJ, Brierley JD, Catton CN, McLean M, Catton P, et al. Treatment of locally recurrent rectal carcinoma-Results and Prognostic factors. Int J Radiat Oncol Biol Phys 1998;40(2):427-35. https://doi.org/10.1016/S0360-3016(97)00737-2
  16. Hocht S, Hammad R, Thiel HJ, Wiegel T, Siegmann A, Wilner J, et al. Recurrent rectal cancer within the pelvis: a multicenter analysis of 123 patients and recommendations for adjuvant radiotherapy. Strahlenther Onkol 2004;180(1):15-20. https://doi.org/10.1007/s00066-004-1130-8