The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지
DOI QR코드

DOI QR Code

A Retrospective Study of the Safety and Effect of Co-administration of Glucose-lowering Medication and Bojungikgi-tang on Blood Glucose Level in Patients with Type 2 Diabetes Mellitus

제2형 당뇨병 환자에서 혈당강하제와 보중익기탕 병용 투여가 혈당 변화에 미치는 영향 및 안전성 연구

  • Seung-hyun Oh (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Woo-nyoung Jung (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Mee-ryoung Song (Dept. of Nephrology and Endocrinology, College of Korean Medicine, Kyung Hee University) ;
  • Ji-won Noh (Dept. of Nephrology and Endocrinology, College of Korean Medicine, Kyung Hee University) ;
  • Young-min Ahn (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Se-young Ahn (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Byung-cheol Lee (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University)
  • 오승현 (경희대학교 대학원 임상한의학과) ;
  • 정우녕 (경희대학교 대학원 임상한의학과) ;
  • 송미령 (경희대학교 한의과대학 부속병원 신장내분비내과교실) ;
  • 노지원 (경희대학교 한의과대학 부속병원 신장내분비내과교실) ;
  • 안영민 (경희대학교 대학원 임상한의학과) ;
  • 안세영 (경희대학교 대학원 임상한의학과) ;
  • 이병철 (경희대학교 대학원 임상한의학과)
  • Received : 2023.04.21
  • Accepted : 2023.07.05
  • Published : 2023.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objective: This study aimed to assess the safety and effect on glucose level of Bojungikgi-tang in patients with type 2 diabetes mellitus. Methods: To review patients' clinical characteristics and laboratory tests retrospectively, we investigated 15 hospitalized patients with type 2 diabetes mellitus who took Bojungikgi-tang at Kyung Hee University Korean Medical Hospital for at least one day between January 2012 and December 2022. The blood glucose levels, including fasting blood sugar (FBS), 2-hour postprandial glucose (PP2) levels, and glycated hemoglobin level, were collected to determine the effect of the Bojungikgi-tang on blood sugar changes. Furthermore, to evaluate the safety of Bojungikgi-tang, hepatic function and renal function tests were implemented, including aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, γ-glutamyltransferase, blood urea nitrogen, creatinine, and Modification of Diet in Renal Disease estimated glomerular filtration rate. Results: When Bojungikgi-tang and a standard treatment for diabetes were administered for patients with type 2 diabetes, it was confirmed that there were no statistically significant changes in FBS and PP2 levels in the analysis of each medication taken. There was no significant difference in the safety profile after taking Bojungikgi-tang. Conclusions: The combined administration of Bojungikgi-tang with standard hypoglycemic medication for patients with type 2 diabetes may not affect blood glucose levels and safety.

Keywords

Acknowledgement

본 연구는 보건복지부의 재원으로 한국보건산업진흥원의 보건의료기술 연구개발사업 지원에 의하여 이루어진 것임(HF20C0022).

References

  1. Korean diabetes association. Diabetes fact sheet in Korea 2022. Oct 4 2022.
  2. 대한내분비학회. 내분비대사학. 3판. 서울: 군자 출판사; 2022, p. 896-7, 909.
  3. Diabetes guideline committee. Treatment guideline for diabetes 2021. Seoul: Korean diabetes association; 2021, p. 37, 42, 89-139.
  4. Yu CH, Kang SW, Hong SE, Kim KI, Jung HJ, Lee BJ. The effect of herbal medicine on blood glucose in type 2 diabetes patients: A retrospective study. J Int Korean Med 2020;41(6):1066-77. https://doi.org/10.22246/jikm.2020.41.6.1066
  5. Oh SH, Lee MS, Jung WN, Noh JW, Ahn YM, Ahn SY, et al. A retrospective study of the effectiveness and safety of banhasasim-tang, gumiganghwal-tang, or pyeongwee-san in patients with type 2 diabetes mellitus. J Int Korean Med 2022;43(3):363-74.
  6. Lee MS, Jeong SM, Oh SH, Lee HY, Leem HG Ahn YM, et al. A retrospective study on the effect of the co-administration of ojeok-san and hypoglycemic agents on blood glucose levels in type 2 diabetes mellitus. J Int Korean Med 2021;42(1):40-52. https://doi.org/10.22246/jikm.2021.42.1.40
  7. 건강보험심사평가원. 2021급여의약품 청구현황. 건강보험심사평가원; 2022, p. 76-8.
  8. 식품의약품안전처. 의약품안전나라. April 18;2023 http://mfds.go.kr/
  9. Huang P. Effect of modified Buzhong Yiqi decoction on blood glucose level in diabetic patients. Clinical medical & engineering 2015;22(5):596-7.
  10. Kim JM, Kim SS. Management of hyperglycemia in type 2 diabetes: a summary of new consensus report from the American Diabetes Association and the European Association for the study of diabetes in 2018. J Korean Diabetes 2019;20(1):6-9. https://doi.org/10.4093/jkd.2019.20.1.6
  11. Hur KY. 2021 Clinical practice guidelines for diabetes: pharmacotherapy and the Korean diabetes association support system. J Korean diabetes 2021;22(4):250-8. https://doi.org/10.4093/jkd.2021.22.4.250
  12. Moon SJ, Baek SM, Park JH, Lee SH, Seo HJ, Kim SG, et al. The use of complementary and alternative medicine in patients with type 2 diabetes mellitus: community based survey. Korean J Orient Int Med 2012;33(3):317-26.
  13. Lee YK, Choi GH, Shin HC, Kang SB. The latest study trend about DM and So-gal-search oriental medical science article from 2003 to 2007. The Korean Journal of oriental medical prescription 2007;15(2):21-33.
  14. Kim DH, Park SC, Lee JH, Lee HY, Cho MK, Choi JY, et al. Recent research trends in Korean medicine treatment of diabetes mellitus-focusing on domestic articles from 2008 to 2013. Korean J Orient Int Med 2013;34(3):240-55.
  15. Son AH, Koh JY, Lee DK, Shin HS. Review of domestic experimental studies of Korean medicine treatment for diabetes mellitus since 2013. J Int Korean Med 2017;38(1):10-9. https://doi.org/10.22246/jikm.2017.38.1.10
  16. Choi HM, Kim HH, Lee HD. Comparative study of bojungikgitang in Korea, Japan and China on the anti-inflammatory and anti-oxidative effects. Kor J Herbology 2014;29(1):53-60. https://doi.org/10.6116/kjh.2014.29.1.53
  17. 范军. 补中益气汤加味治疗糖尿病肾病100例. 陕西中医. 2011;32(8):960-2.
  18. Kang YM, Kim HJ, Park YB, Jeong CM, Ham SH, Yang WM, et al. The Effects of Bojungikgi-tang on Streptozotocin-induced Diabetic Gastroparesis Rat Model. Kor J Herbol 2019;34(6):45-55.
  19. Park SD, Go WD, Sin HS. Effects of Bojungikgitang, Soeumin bojungikgitang and its component groups on diabetes in alloxan induced diabetic rats. Herbal Formula Science 2001;9(1):215-30.
  20. Jeong SM, Noh JW, Lee MS, Yang HG, Ahn YM, Ahn SY, et al. A retrospective study on the effect of herbal extracts combined with conventional therapy on blood glucose in type 2 diabetes mellitus. The J of Internal Korean Medicine 2020;41(6):1231-44. https://doi.org/10.22246/jikm.2020.41.6.1231