Acknowledgement
Johns Hopkins Institutional Training Grant for Pediatricians, funded by NICHD.
References
- Freeman HJ. Natural history and long-term clinical course of Crohn's disease. World J Gastroenterol 2014;20:31-6. https://doi.org/10.3748/wjg.v20.i1.31
- Cuffari C. Diagnostic Considerations in Pediatric Inflammatory Bowel Disease Management. Gastroenterol Hepatol (N Y) 2009;5:775-83.
- Sauer CG, Kugathasan S. Pediatric inflammatory bowel disease: highlighting pediatric differences in IBD. Gastroenterol Clin North Am 2009;38:611-28. https://doi.org/10.1016/j.gtc.2009.07.010
- Walker WA, Kleinman R. Crohn's disease. In: Kleinman RE, ed. Walker's Pediatric Gastrointestinal Disease. 5th ed. BC Decker, 2008:519-39.
- Rieder F, Zimmermann EM, Remzi FH, Sandborn WJ. Crohn's disease complicated by strictures: a systematic review. Gut 2013;62:1072-84. https://doi.org/10.1136/gutjnl-2012-304353
- Li J, Mao R, Kurada S, Wang J, Lin S, Chandra J, et al. Pathogenesis of fibrostenosing Crohn's disease. Transl Res 2019;209:39-54. https://doi.org/10.1016/j.trsl.2019.03.005
- Ntoulia A, Anupindi SA, Darge K, Back SJ. Applications of contrast-enhanced ultrasound in the pediatric abdomen. Abdom Radiol (NY) 2018;43:948-59. https://doi.org/10.1007/s00261-017-1315-0
- McMahon CJ, Ayres NA, Bezold LI, Lewin MB, Alonzo M, Altman CA, et al. Safety and efficacy of intravenous contrast imaging in pediatric echocardiography. Pediatr Cardiol 2005;26:413-7. https://doi.org/10.1007/s00246-004-0795-1
- Piskunowicz M, Kosiak W, Batko T, Piankowski A, Polczynska K, Adamkiewicz-Drozynska E. Safety of intravenous application of second-generation ultrasound contrast agent in children: prospective analysis. Ultrasound Med Biol 2015;41:1095-9. https://doi.org/10.1016/j.ultrasmedbio.2014.11.003
- Darge K, Papadopoulou F, Ntoulia A, et al. Safety of contrast-enhanced ultrasound in children for non-cardiac applications: a review by the Society for Pediatric Radiology (SPR) and the International Contrast Ultrasound Society (ICUS). Pediatr Radiol 2013;43:1063-73. https://doi.org/10.1007/s00247-013-2746-6
- Sidhu PS, Cantisani V, Deganello A, Dietrich CF, Duran C, Franke D, et al. Role of contrast-enhanced ultrasound (CEUS) in paediatric practice: an EFSUMB position statement. Ultraschall Med 2017;38:33-43.
- Rafailidis V, Deganello A, Watson T, Sidhu PS, Sellars ME. Enhancing the role of paediatric ultrasound with microbubbles: a review of intravenous applications. Br J Radiol 2017;90:20160556.
- Serafin Z, Bialecki M, Bialecka A, Sconfienza LM, Klopocka M. Contrast-enhanced ultrasound for detection of Crohn's disease activity: systematic review and meta-analysis. J Crohn's Colitis 2015;10:354-62. https://doi.org/10.1093/ecco-jcc/jjv196
- Ripolles T, Rausell N, Paredes JM, Grau E, Martinez MJ, Vizuete J. Effectiveness of contrast-enhanced ultrasound for characterisation of intestinal inflammation in Crohn's disease: A comparison with surgical histopathology analysis. J Crohn's Colitis 2013;7:120-8. https://doi.org/10.1016/j.crohns.2012.03.002
- Medellin A, Merrill C, Wilson SR. Role of contrast-enhanced ultrasound in evaluation of the bowel. Abdom Radiol (NY) 2018;43:918-33. https://doi.org/10.1007/s00261-017-1399-6
- Quaia E, Gennari AG, Van Beek EJR. Differentiation of inflammatory from fibrotic ileal strictures among patients with Crohn's disease through analysis of time-intensity curves obtained after microbubble contrast agent injection. Ultrasound Med Biol 2017;43:1171-8. https://doi.org/10.1016/j.ultrasmedbio.2017.01.024
- Kljucevsek D, Vidmar D, Urlep D, Dezman R. Dynamic contrast-enhanced ultrasound of the bowel wall with quantitative assessment of Crohn's disease activity in childhood. Radiol Oncol 2016;50:347-54. https://doi.org/10.1515/raon-2015-0042
- Hwang M, Lyshchik A, Fleischer AC. Molecular sonography with targeted microbubbles: current investigations and potential applications. Ultrasound Q 2010;26:75-82. https://doi.org/10.1097/RUQ.0b013e3181df96de
- US Food and Drug Administration. Lumason Full Prescribing Information [Internet]. US Food and Drug Administration; 2016 [cited 2016 Dec]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/203684s009lbl.pdf
- Rieder F, Zimmermann EM, Remzi FH, Sandborn WJ. Crohn's disease complicated by strictures: a systematic review. Gut 2013;62:1072-84. https://doi.org/10.1136/gutjnl-2012-304353
- Kugathasan S, Denson LA, Walters TD, Kim MO, Marigorta UM, Schirmer M, et al. Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study. Lancet 2017;389:1710-8. https://doi.org/10.1016/S0140-6736(17)30317-3
- Jacene HA, Ginsburg P, Kwon J, Nguyen GC, Montgomery EA, Bayless TM, et al. Prediction of the need for surgical intervention in obstructive Crohn's disease by 18F-FDG PET/CT. J Nucl Med 2009;50:1751-9. https://doi.org/10.2967/jnumed.109.065466
- Darbari A, Sena L, Argani P, Oliva-Hemker JM, Thompson R, Cuffari C. Gadolinium-enhanced magnetic resonance imaging: a useful radiological tool in diagnosing pediatric IBD. Inflamm Bowel Dis 2004;10:67-72. https://doi.org/10.1097/00054725-200403000-00001
- Migaleddu V, Scanu AM, Quaia E, Rocca PC, Dore MP, Scanu D, et al. Contrast-enhanced ultrasonographic evaluation of inflammatory activity in Crohn's disease. Gastroenterology 2009;137:43-52. https://doi.org/10.1053/j.gastro.2009.03.062