Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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Golgi Stress Response: New Insights into the Pathogenesis and Therapeutic Targets of Human Diseases

  • Won Kyu Kim (Natural Product Research Center, Korea Institute of Science and Technology (KIST)) ;
  • Wooseon Choi (Department of Pharmacology, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea) ;
  • Barsha Deshar (Department of Pharmacology, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea) ;
  • Shinwon Kang (Department of Physiology, University of Toronto) ;
  • Jiyoon Kim (Department of Pharmacology, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea)
  • Received : 2022.09.27
  • Accepted : 2022.10.30
  • Published : 2023.04.30
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Abstract

The Golgi apparatus modifies and transports secretory and membrane proteins. In some instances, the production of secretory and membrane proteins exceeds the capacity of the Golgi apparatus, including vesicle trafficking and the post-translational modification of macromolecules. These proteins are not modified or delivered appropriately due to the insufficiency in the Golgi function. These conditions disturb Golgi homeostasis and induce a cellular condition known as Golgi stress, causing cells to activate the 'Golgi stress response,' which is a homeostatic process to increase the capacity of the Golgi based on cellular requirements. Since the Golgi functions are diverse, several response pathways involving TFE3, HSP47, CREB3, proteoglycan, mucin, MAPK/ETS, and PERK regulate the capacity of each Golgi function separately. Understanding the Golgi stress response is crucial for revealing the mechanisms underlying Golgi dynamics and its effect on human health because many signaling molecules are related to diseases, ranging from viral infections to fatal neurodegenerative diseases. Therefore, it is valuable to summarize and investigate the mechanisms underlying Golgi stress response in disease pathogenesis, as they may contribute to developing novel therapeutic strategies. In this review, we investigate the perturbations and stress signaling of the Golgi, as well as the therapeutic potentials of new strategies for treating Golgi stress-associated diseases.

Keywords

Acknowledgement

This work was supported by the National Research Foundation (NRF), funded by the Ministry of Science and ICT, Republic of Korea (No. 2021R1C1C1008587), the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), and Korea Dementia Research Center (KDRC) funded by the Ministry of Health & Welfare and Ministry of Science and ICT, Republic of Korea (No. HU22C0069), and the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare, the Republic of Korea (No. HI22C1236).

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