Clinical Nutrition Research

  • 제12권4호
  • /
  • Pages.293-303
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  • 2023
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  • 2287-3732(pISSN)
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  • 2287-3740(eISSN)
한국임상영양학회 (The Korean Society of Clinical Nutrition)
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Muscle Strength and Biochemical Markers as Predictors of Depression in Hemodialysis Patients: A Cross-Sectional Study

  • Soudabeh Zare (Department of Nutrition, School of Public Health, Iran University of Medical Sciences) ;
  • Motahareh Hasani (Department of Nutritional Sciences, School of Health, Golestan University of Medical Sciences) ;
  • M. Dulce Estevao (Universidade do Algarve, Escola Superior de Saude) ;
  • Rahim Tahmasebi (Department of Epidemiology & Biostatistics, School of Health, Bushehr University of Medical Sciences) ;
  • Leila Azadbakht (Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences) ;
  • Farzad Shidfar (Department of Nutrition, School of Public Health, Iran University of Medical Sciences) ;
  • Javad Heshmati (ICU Department, Imam Reza Hospital, Kermanshah University of Medical Sciences) ;
  • Somayeh Ziaei (ICU Department, Imam Reza Hospital, Kermanshah University of Medical Sciences)
  • 투고 : 2023.07.26
  • 심사 : 2023.10.06
  • 발행 : 2023.10.30
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초록

Patients with chronic renal failure, many of which treated with hemodialysis, present a high prevalence of impaired muscle strength which suggest that muscle mass parameters may be used as markers for changes in muscle in these patients. Measurement of handgrip strength (HGS) is a common, simple, and quick measure of muscle function an indicator of overall muscle strength which has been associated with physical activity and several anthropometric traits. Intercellular adhesion molecule-1 (ICAM-1) and insulin-like growth factor-1 (IGF-1) are biochemical markers associated with inflammatory processes which are a common consequence of dialysis. Additionally, hemodialysis patients frequently present signs of malnutrition and depression. This cross-sectional study aimed to evaluate if muscle and biochemical markers could be used to predict the risk of depression in hemodialysis patients. Several anthropometric parameters, nutrient intake, depression state and the serum levels of ICAM-1 and IGF-1 were determined and Pearson's correlation coefficient and/or Spearman's correlation coefficient were used to test the correlation between them. Our results do not show a correlation between HGF, IGF-1 and ICAM-1 with the depression status of the patients, but mid-arm muscle circumference (MAMC) was statistically and positively correlated with depression. Additionally, ICAM-1 levels were negatively correlated with HGS, MAMC, and IGF-1. Overall, the results of the present study suggest that HGS may be used as an indicator of cardiovascular diseases and MAMC may be a good predictor of the level of depression in hemodialysis patients, although further studies are required.

키워드

과제정보

This research is done by financial support of Iran University of Medical Sciences, Tehran, Iran.

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